Publications by authors named "Karl Box"

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Predicting Food Effect On Oral Drug Absorption For Solubility-Epithelial Membrane Permeation-Limited Cases With Bile Micelle Solubilization.
Yuji Higashiguchi, Shiori Ishida, Samuel Lee, Balint Sinko, Karl Box

Pharm Res· October 2025

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Effect of bicarbonate buffer on artificial membrane permeation of drugs.
Shiori Ishida, Samuel Lee, Balint Sinko, Karl Box, Kiyohiko Sugano

ADMET DMPK· January 2025

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Predictions of biorelevant solubility change during dispersion and digestion of lipid-based formulations.
Lotte Ejskjær, René Holm, Martin Kuentz, Karl J Box, Brendan T Griffin

Eur J Pharm Sci· September 2024

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Developing an in vitro lipolysis model for real-time analysis of drug concentrations during digestion of lipid-based formulations.
Lotte Ejskjær, Patrick J O'Dwyer, Callum D Ryan, René Holm, Martin Kuentz, Karl J Box

Eur J Pharm Sci· March 2024

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Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five.
Sven Stegemann, Chris Moreton, Sami Svanbäck, Karl Box, Geneviève Motte

Drug Discov Today· February 2023

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On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state.
Patrick J O'Dwyer, Karl J Box, Georgios Imanidis, Maria Vertzoni, Christos Reppas

Eur J Pharm Sci· January 2022

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Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration.
Patrick J O'Dwyer, Karl J Box, Jennifer Dressman, Brendan T Griffin, Laura J Henze

J Pharm Pharmacol· March 2021

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Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number.
Harriet Bennett-Lenane, Niklas J Koehl, Patrick J O'Dwyer, Karl J Box, Joseph P O'Shea

J Pharm Sci· January 2021

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Novel Biphasic Lipolysis Method To Predict Performance of Lipid-Based Formulations.
Patrick J O'Dwyer, Karl J Box, Niklas J Koehl, Harriet Bennett-Lenane, Christos Reppas

Mol Pharm· September 2020

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Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state.
Chara Litou, David B Turner, Nico Holmstock, Jens Ceulemans, Karl J Box

Eur J Pharm Sci· June 2020

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On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development.
Patrick J O'Dwyer, Georgios Imanidis, Karl J Box, Christos Reppas

Pharmaceutics· March 2020

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Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states.
Chara Litou, Nikunjkumar Patel, David B Turner, Edmund Kostewicz, Martin Kuentz, Karl J Box

Eur J Pharm Sci· October 2019

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Biphasic drug release testing coupled with diffusing wave spectroscopy for mechanistic understanding of solid dispersion performance.
Sandra Jankovic, Patrick J O'Dwyer, Karl J Box, Georgios Imanidis, Christos Reppas

Eur J Pharm Sci· September 2019

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Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects.
Christel A S Bergström, Karl Box, René Holm, Wayne Matthews, Mark McAllister

Eur J Pharm Biopharm· June 2019

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In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review.
Patrick J O'Dwyer, Chara Litou, Karl J Box, Jennifer B Dressman, Edmund S Kostewicz

J Pharm Pharmacol· April 2019

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Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review.
Chara Litou, Angela Effinger, Edmund S Kostewicz, Karl J Box, Nikoletta Fotaki

J Pharm Pharmacol· April 2019

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In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Ondrej Soukup, Jan Korabecny, David Malinak, Eugenie Nepovimova, Ngoc L Pham, Karl Box

Med Chem· August 2018

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Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method.
Elisenda Fornells, Elisabet Fuguet, Meritxell Mañé, Rebeca Ruiz, Karl Box

Eur J Pharm Sci· May 2018

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Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination.
Adam Ward, Karl Walton, Karl Box, Jesper Østergaard, Lisa J Gillie

Int J Pharm· September 2017

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Considerations for the development of in vitro dissolution tests to reduce or replace preclinical oral absorption studies.
Elise Grignard, Robert Taylor, Mark McAllister, Karl Box, Nikoletta Fotaki

Eur J Pharm Sci· March 2017

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Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration.
Karl J Box, John Comer, Robert Taylor, Shyam Karki, Rebeca Ruiz

AAPS PharmSciTech· April 2016

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pH-Dependent Liquid-Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs.
Anura S Indulkar, Karl J Box, Robert Taylor, Rebeca Ruiz, Lynne S Taylor

Mol Pharm· July 2015

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Assessing the impact of polymers on the pH-induced precipitation behavior of poorly water soluble compounds using synchrotron wide angle X-ray scattering.
Yi-Ling Hsieh, Karl Box, Lynne S Taylor

J Pharm Sci· September 2014

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Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs.
Christel A S Bergström, René Holm, Søren Astrup Jørgensen, Sara B E Andersson, Per Artursson, Karl Box

Eur J Pharm Sci· June 2014

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pH-Induced precipitation behavior of weakly basic compounds: determination of extent and duration of supersaturation using potentiometric titration and correlation to solid state properties.
Yi-Ling Hsieh, Grace A Ilevbare, Bernard Van Eerdenbrugh, Karl J Box, Manuel Vincente Sanchez-Felix

Pharm Res· October 2012

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