Publications by authors named "Karl Simin"

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MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T-cell and Immunotherapy Responses in Prostate Cancer.
Katherine C Murphy, Kelly D DeMarco, Lin Zhou, Jessica Peura, Hadiya K Giwa, Karl Simin

Cancer Res· November 2025

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P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy.
Lin Zhou, Kelly D DeMarco, Katherine C Murphy, Zhenpeng Wu, Jinping Li, Karl Simin

Cancer Discov· October 2025

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PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors.
Shreya R Chowdhury, Chaitanya N Parikh, Arshia N Kaur, Kelly D DeMarco, Hadiya K Giwa, Karl Simin

Proc Natl Acad Sci U S A· September 2025

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Mitochondrial Ca controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity.
Jillian S Weissenrieder, Jessica Peura, Usha Paudel, Nikita Bhalerao, Natalie Weinmann, Karl Simin

Cell Rep· May 2025

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Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository.
John Broach, Chad Achenbach, Stephanie Behar, Laurel O'Connor, Seanan Tarrant, Karl Simin

BMC Infect Dis· November 2024

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Mitochondrial Ca controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity.
Jillian S Weissenrieder, Jessica Peura, Usha Paudel, Nikita Bhalerao, Natalie Weinmann, Karl Simin

bioRxiv· August 2024

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MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer.
Katherine C Murphy, Kelly D DeMarco, Lin Zhou, Yvette Lopez-Diaz, Yu-Jui Ho, Karl Simin

bioRxiv· July 2024

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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer.
Alok K Mishra, Tianyi Ye, Shahid Banday, Ritesh P Thakare, Chinh Tran-To Su, Karl Simin

Cell Rep· April 2024

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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells.
Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Karl Simin

Nature· November 2023

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Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with disruptions.
Shyam A Patel, Jan Cerny, William K Gerber, Muthalagu Ramanathan, Asiri Ediriwickrema, Karl Simin

EJHaem· November 2023

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EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance.
Loretah Chibaya, Katherine C Murphy, Kelly D DeMarco, Sneha Gopalan, Haibo Liu, Karl Simin

Nat Cancer· June 2023

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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells.
Meghan E Spears, Namgyu Lee, Sunyoung Hwang, Sung Jin Park, Anne E Carlisle, Karl Simin

Cell Rep· September 2022

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COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study.
Qiming Shi, Carly Herbert, Doyle V Ward, Karl Simin, Beth A McCormick

JMIR Form Res· June 2022

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Clinico-genomic profiling and clonal dynamic modeling of -aberrant myelodysplastic syndrome and acute myeloid leukemia.
Shyam A Patel, Maxwell R Lloyd, Jan Cerny, Qiming Shi, Karl Simin

Leuk Lymphoma· December 2021

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SepA Enhances Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant.
Mario Meza-Segura, James R Birtley, Ana Maldonado-Contreras, Christian Mueller, Karl J Simin

mBio· December 2021

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SARS-CoV-2 Reinfection in a Liver Transplant Recipient.
Christopher H Tomkins-Tinch, Jennifer S Daly, Adrianne Gladden-Young, Nicole M Theodoropoulos, Michael P Madaio, Karl Simin

Ann Intern Med· August 2021

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The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change.
Eric Nehl, Stacy Heilman, David Ku, David Gottfried, Sarah Farmer, Karl Simin

IEEE Open J Eng Med Biol· April 2021

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Selenium detoxification is required for cancer-cell survival.
Anne E Carlisle, Namgyu Lee, Asia N Matthew-Onabanjo, Meghan E Spears, Sung Jin Park, Karl Simin

Nat Metab· July 2020

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Gene expression signature of atypical breast hyperplasia and regulation by SFRP1.
Kelly J Gregory, Amy L Roberts, Erin M Conlon, Jacob A Mayfield, Mary J Hagen, Karl Simin

Breast Cancer Res· June 2019

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The Dkk3 gene encodes a vital intracellular regulator of cell proliferation.
Jack L Leonard, Deborah M Leonard, Scot A Wolfe, Jilin Liu, Jaime Rivera, Karl J Simin

PLoS One· September 2017

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Correction: The Dkk3 gene encodes a vital intracellular regulator of cell proliferation.
Jack L Leonard, Deborah M Leonard, Scot A Wolfe, Jilin Liu, Jaime Rivera, Karl J Simin

PLoS One· September 2017

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Aldehyde Dehydrogenase Is Regulated by β-Catenin/TCF and Promotes Radioresistance in Prostate Cancer Progenitor Cells.
Monica Cojoc, Claudia Peitzsch, Ina Kurth, Franziska Trautmann, Leoni A Kunz-Schughart, Karl Simin

Cancer Res· April 2015

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Crucial and novel cancer drivers in a mouse model of triple-negative breast cancer.
Jacob P S Johnson, Prashant Kumar, Miroslav Koulnis, Milan Patel, Karl Simin

Cancer Genomics Proteomics· February 2015

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Cooperativity of Rb, Brca1, and p53 in malignant breast cancer evolution.
Prashant Kumar, Malini Mukherjee, Jacob P S Johnson, Milan Patel, Bing Huey, Karl Simin

PLoS Genet· May 2013

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GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.
Hira Lal Goel, Bryan Pursell, Cheng Chang, Leslie M Shaw, Junhao Mao, Karl Simin

EMBO Mol Med· April 2013

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