Publications by authors named "Kasper Lage"

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Rare genetic variants confer a high risk of ADHD and implicate neuronal biology.
Ditte Demontis, Jinjie Duan, Yu-Han H Hsu, Greta Pintacuda, Jakob Grove, Kasper Lage

Nature· November 2025

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Genome-wide rules of transcription factor cooperativity revealed through binding site ablation.
Xuening He, Hjörleifur Einarsson, Petra Páleníková, Sarah Rennie, Dewei Hu, Kasper Lage

bioRxiv· June 2025

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A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia.
Greta Pintacuda, Yu-Han H Hsu, Petra Páleníková, Ugne Dubonyte, Nadine Fornelos, Kasper Lage

medRxiv· May 2025

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Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.
Slavica Dimitrieva, Jon M Harrison, Jonathan Chang, Michelle Piquet, Mari Mino-Kenudson, Kasper Lage

Cancer Res Commun· December 2024

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Systematic multi-trait AAV capsid engineering for efficient gene delivery.
Fatma-Elzahraa Eid, Albert T Chen, Ken Y Chan, Qin Huang, Qingxia Zheng, Kasper Lage

Nat Commun· August 2024

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CSMD1 regulates brain complement activity and circuit development.
Matthew L Baum, Daniel K Wilton, Rachel G Fox, Alanna Carey, Yu-Han H Hsu, Kasper Lage

Brain Behav Immun· July 2024

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Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease.
Qiuyu Martin Zhu, Yu-Han H Hsu, Frederik H Lassen, Bryan T MacDonald, Stephanie Stead, Kasper Lage

Commun Biol· January 2024

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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.
Elle M Weeks, Jacob C Ulirsch, Nathan Y Cheng, Brian L Trippe, Rebecca S Fine, Kasper Lage

Nat Genet· August 2023

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Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Yu-Han H Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kasper Lage

iScience· May 2023

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Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Greta Pintacuda, Yu-Han H Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M Martín, Kasper Lage

Cell Genom· March 2023

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Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells.
Ugne Dubonyte, Andrea Asenjo-Martinez, Thomas Werge, Kasper Lage, Agnete Kirkeby

Acta Neuropathol Commun· December 2022

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Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
Qiuyu Martin Zhu, Bryan T MacDonald, Taiji Mizoguchi, Mark Chaffin, Alison Leed, Kasper Lage

Cardiovasc Res· October 2022

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Autism genes converge on asynchronous development of shared neuron classes.
Bruna Paulsen, Silvia Velasco, Amanda J Kedaigle, Martina Pigoni, Giorgia Quadrato, Kasper Lage

Nature· February 2022

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Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.
Christopher L Hartl, Gokul Ramaswami, William G Pembroke, Sandrine Muller, Greta Pintacuda, Kasper Lage

Nat Neurosci· September 2021

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Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction.
Jiangming Sun, Yunpeng Wang, Lasse Folkersen, Yan Borné, Inge Amlien, Kasper Lage

Nat Commun· September 2021

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is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing.
Ellen M Beauchamp, Matthew Leventhal, Elsa Bernard, Emma R Hoppe, Gabriele Todisco, Kasper Lage

Blood Cancer Discov· September 2021

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Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data.
Greta Pintacuda, Frederik H Lassen, Yu-Han H Hsu, April Kim, Jacqueline M Martín, Kasper Lage

Nat Commun· May 2021

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Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.
Blandine Roux, Camille Vaganay, Jesse D Vargas, Gabriela Alexe, Chaima Benaksas, Kasper Lage

Sci Transl Med· March 2021

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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
Zuzana Tothova, Anne-Laure Valton, Rebecca A Gorelov, Mounica Vallurupalli, John M Krill-Burger, Kasper Lage

JCI Insight· February 2021

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Systematic auditing is essential to debiasing machine learning in biology.
Fatma-Elzahraa Eid, Haitham A Elmarakeby, Yujia Alina Chan, Nadine Fornelos, Mahmoud ElHefnawi, Kasper Lage

Commun Biol· February 2021

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Leadership.
Dawn Bowdish, Tejal A Desai, Angela DePace, Elizabeth S Haswell, David Baltrus, Kasper Lage

Cell Syst· January 2021

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Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.
Sumaiya Iqbal, Eduardo Pérez-Palma, Jakob B Jespersen, Patrick May, David Hoksza, Kasper Lage

Proc Natl Acad Sci U S A· November 2020

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TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
Erica E Davis, Ravikumar Balasubramanian, Zachary A Kupchinsky, David L Keefe, Lacey Plummer, Kasper Lage

Hum Mol Genet· August 2020

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BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Reza Pourhaghighi, Peter E A Ash, Sadhna Phanse, Florian Goebels, Lucas Z M Hu, Kasper Lage

Cell Syst· August 2020

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Prediction of cancer driver genes through network-based moment propagation of mutation scores.
Anja C Gumpinger, Kasper Lage, Heiko Horn, Karsten Borgwardt

Bioinformatics· July 2020

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