Publications by authors named "Kaylene Simpson"

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macpie: Scalable workflow for high-throughput transcriptomic profiling.
Nenad Bartonicek, Xin Liu, Laura Twomey, Michelle Meier, Richard Lupat, Kaylene J Simpson

Comput Struct Biotechnol J· December 2025

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Discovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity.
Olivia Susanto, Emily Gruber, Cheng Mun Wun, Rheana L Franich, Xiao Ma, Kaylene J Simpson

Mol Cancer Ther· November 2025

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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation.
Jennifer R Devlin, Ben Martin, Nenad Bartonicek, Keziah Ting, Zheng Fan, Kaylene J Simpson

Mol Cell· September 2025

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Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer.
Carmelo Cerra, Madeleine R C Tancock, Niko Thio, Ada Koo, AnnRann Wong, Kaylene J Simpson

Cell Death Discov· September 2025

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JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer.
Sarah Alexandrou, Christine S Lee, Kristine J Fernandez, Celine E Wiharja, Leila Eshraghi, Kaylene J Simpson

J Exp Clin Cancer Res· August 2025

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Genome-wide analysis of host-encoded microRNAs modulating SARS-CoV-2 infection.
Christina L Rootes, Karla J Cowley, Aaron M Brice, Henry G Beetham, Rasan Mohamed Sathiqu, Kaylene J Simpson

Sci Data· July 2025

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RNA kinetics influence the response to transcriptional perturbation in leukaemia cell lines.
Izabela Todorovski, Mary-Jane Tsang, Breon Feran, Zheng Fan, Sreeja Gadipally, Kaylene J Simpson

NAR Cancer· December 2024

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Author Correction: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer.
Razia Rahman, Muhammed H Rahaman, Adrienne R Hanson, Nicholas Choo, Jianling Xie, Kaylene J Simpson

Br J Cancer· November 2024

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GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing.
Jacki E Heraud-Farlow, Scott R Taylor, Alistair M Chalk, Adriana Escudero, Shi-Bin Hu, Kaylene J Simpson

Sci Immunol· November 2024

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CDK9 inhibition inhibits multiple oncogenic transcriptional and epigenetic pathways in prostate cancer.
Razia Rahman, Muhammed H Rahaman, Adrienne R Hanson, Nicholas Choo, Jianling Xie, Kaylene J Simpson

Br J Cancer· October 2024

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A new method for network bioinformatics identifies novel drug targets for mucinous ovarian carcinoma.
Olivia Craig, Samuel Lee, Courtney Pilcher, Rita Saoud, Suad Abdirahman, Kaylene J Simpson

NAR Genom Bioinform· September 2024

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High-throughput drug screening identifies novel therapeutics for Low Grade Serous Ovarian Carcinoma.
Kathleen I Pishas, Karla J Cowley, Marta Llaurado-Fernandez, Hannah Kim, Jennii Luu, Kaylene J Simpson

Sci Data· September 2024

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A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells.
Jenna Hall, Maciej Daniszewski, Shane Cheung, Kalyan Shobhana, Himeesh Kumar, Kaylene J Simpson

SLAS Technol· June 2024

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Co-targeting BET, CBP, and p300 inhibits neuroendocrine signalling in androgen receptor-null prostate cancer.
Nicholas Choo, Shivakumar Keerthikumar, Susanne Ramm, Daisaku Ashikari, Linda Teng, Kaylene J Simpson

J Pathol· June 2024

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miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma.
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Kaylene J Simpson

Mol Ther· June 2024

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Hit-to-lead optimization of 2-aminoquinazolines as anti-microbial agents against Leishmania donovani.
Nirmal Das, Jayasree Roy, Binita Patra, Eleanor Saunders, Dipika Sarkar, Kaylene Simpson

Eur J Med Chem· April 2024

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Perspectives on phenotypic screening-Screen Design and Assay Technology Special Interest Group.
Chorom Pak, Kaylene J Simpson, Andrea D Weston, Mary Ellen Cvijic, Kenda Evans

SLAS Discov· March 2024

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Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network.
Richard G Lee, Danielle L Rudler, Samuel A Raven, Liuyu Peng, Anaëlle Chopin, Kaylene J Simpson

Nat Cell Biol· January 2024

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A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to Lutetium-DOTA-octreotate radionuclide therapy.
Kelly Waldeck, Jessica Van Zuylekom, Carleen Cullinane, Twishi Gulati, Kaylene J Simpson

Theranostics· October 2023

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Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.
Winnie L Kan, Urmi Dhagat, Kerstin B Kaufmann, Timothy R Hercus, Tracy L Nero, Kaylene J Simpson

Cancer Discov· August 2023

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MAC-Seq: Coupling Low-Cost, High-Throughput RNA-Seq with Image-Based Phenotypic Screening in 2D and 3D Cell Models.
Xiang Mark Li, David Yoannidis, Susanne Ramm, Jennii Luu, Gisela Mir Arnau, Kaylene J Simpson

Methods Mol Biol· June 2023

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Using a Quantitative High-Throughput Screening Platform to Identify Molecular Targets and Compounds as Repurposing Candidates for Endometriosis.
Molly L Churchill, Sarah J Holdsworth-Carson, Karla J Cowley, Jennii Luu, Kaylene J Simpson

Biomolecules· June 2023

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COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.
Janelle L Hancock, Murugan Kalimutho, Jasmin Straube, Malcolm Lim, Irma Gresshoff, Kaylene J Simpson

J Exp Clin Cancer Res· April 2023

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Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling.
Vinochani Pillay, Lipi Shukla, Prad Herle, Simon Maciburko, Nadeeka Bandara, Kaylene J Simpson

Front Pharmacol· April 2023

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Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer.
Mohammadreza Alizadeh-Ghodsi, Katie L Owen, Scott L Townley, Damien Zanker, Samuel P G Rollin, Kaylene J Simpson

Cancer Res Commun· July 2022

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