Publications by authors named "Keith G Watson"

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Development of an automated assay for accelerated in vitro detection of DNA adduct-inducing and crosslinking agents.
Jelena Medan, Brad E Sleebs, Kurt Lackovic, Keith G Watson, Benny J Evison

Bioorg Med Chem Lett· March 2021

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Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chüeh, Keith G Watson

Cell Death Dis· March 2021

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A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Mark F van Delft, Stephane Chappaz, Yelena Khakham, Chinh T Bui, Marlyse A Debrincat, Keith G Watson

Nat Chem Biol· November 2019

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Mitoxantrone, More than Just Another Topoisomerase II Poison.
Benny J Evison, Brad E Sleebs, Keith G Watson, Don R Phillips, Suzanne M Cutts

Med Res Rev· March 2016

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Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Zhi-Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M Petros, Keith G Watson

ACS Med Chem Lett· October 2014

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Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
Michael F T Koehler, Philippe Bergeron, Edna F Choo, Kevin Lau, Chudi Ndubaku, Keith G Watson

ACS Med Chem Lett· June 2014

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Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides.
Christopher D Goodman, Vanessa Mollard, Theola Louie, Georgina A Holloway, Keith G Watson

Int J Parasitol· April 2014

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Structure-guided design of a selective BCL-X(L) inhibitor.
Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Keith G Watson

Nat Chem Biol· June 2013

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An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
Susanne C Feil, Stephanie Hamilton, Guy Y Krippner, Bo Lin, Angela Luttick, Keith G Watson

ACS Med Chem Lett· April 2012

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M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.
Benny J Evison, Mile Pastuovic, Rebecca A Bilardi, Robert A Forrest, Paul P Pumuye, Keith G Watson

Biochem Pharmacol· December 2011

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New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation.
Oula C Mansour, Benny J Evison, Brad E Sleebs, Keith G Watson, Abraham Nudelman

J Med Chem· October 2010

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Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity.
Theola Louie, C Dean Goodman, Georgina A Holloway, Geoffrey I McFadden, Vanessa Mollard, Keith G Watson

Bioorg Med Chem Lett· August 2010

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Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library.
Kurt Lackovic, John P Parisot, Nerida Sleebs, Jonathan B Baell, Laurent Debien, Keith G Watson

Antimicrob Agents Chemother· May 2010

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A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim.
Song Xiang, Matthew M Callaghan, Keith G Watson, Liang Tong

Proc Natl Acad Sci U S A· December 2009

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Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Georgina A Holloway, William N Charman, Alan H Fairlamb, Reto Brun, Marcel Kaiser, Keith G Watson

Antimicrob Agents Chemother· July 2009

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Synthesis and biological evaluation of analogues of the anti-tumor alkaloid naamidine A.
Nicholas Aberle, Jenny Catimel, Edouard C Nice, Keith G Watson

Bioorg Med Chem Lett· July 2007

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Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.
Georgina A Holloway, Jonathan B Baell, Alan H Fairlamb, Patrizia M Novello, John P Parisot, Keith G Watson

Bioorg Med Chem Lett· March 2007

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A concise total synthesis of naamidine A.
Nicholas S Aberle, Guillaume Lessene, Keith G Watson

Org Lett· February 2006

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Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin.
Andrew H A Clayton, Matthew A Perugini, Janet Weinstock, Julie Rothacker, Keith G Watson

Anal Biochem· July 2005

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2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder.
Renee N Brown, Rachel Cameron, David K Chalmers, Stephanie Hamilton, Angela Luttick, Keith G Watson

Bioorg Med Chem Lett· April 2005

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Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.
Simon J F Macdonald, Rachel Cameron, Derek A Demaine, Rob J Fenton, Graham Foster, Keith G Watson

J Med Chem· April 2005

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Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen.
Simon J F Macdonald, Keith G Watson, Rachel Cameron, David K Chalmers, Derek A Demaine

Antimicrob Agents Chemother· December 2004

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Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase.
Keith G Watson, Rachel Cameron, Rob J Fenton, David Gower, Stephanie Hamilton

Bioorg Med Chem Lett· March 2004

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An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus.
Keith G Watson, Renee N Brown, Rachel Cameron, David K Chalmers, Stephanie Hamilton

J Med Chem· July 2003

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Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza.
Jennifer L McKimm-Breschkin, Peter M Colman, Betty Jin, Guy Y Krippner, Mandy McDonald, Keith G Watson

Angew Chem Int Ed Engl· July 2003

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