Publications by authors named "Kelly Bales"

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Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler, Kelly R Bales

J Med Chem· June 2024

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Targeting apolipoprotein E for treating Alzheimer's disease.
Kelly R Bales, Steven M Paul

Neurosci Lett· September 2019

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Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains.
Jinbin Xu, Jianjun Sun, Richard J Perrin, Robert H Mach, Kelly R Bales

Ann Clin Transl Neurol· August 2019

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Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion.
Erica Dresselhaus, James M Duerr, Fabien Vincent, Emily K Sylvain, Mercedes Beyna, Kelly R Bales

PLoS One· July 2018

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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
Brian T O'Neill, Elizabeth M Beck, Christopher R Butler, Charles E Nolan, Cathleen Gonzales, Kelly R Bales

J Med Chem· May 2018

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Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain.
Lei Zhang, Laigao Chen, Jason K Dutra, Elizabeth M Beck, Sangram Nag, Kelly R Bales

J Med Chem· April 2018

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Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Martin Pettersson, Douglas S Johnson, Danica A Rankic, Gregory W Kauffman, Christopher W Am Ende, Kelly R Bales

Medchemcomm· April 2017

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The roles of inflammation and immune mechanisms in Alzheimer's disease.
Linda J Van Eldik, Maria C Carrillo, Patricia E Cole, Dominik Feuerbach, Barry D Greenberg, Kelly Bales

Alzheimers Dement (N Y)· June 2016

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Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity.
Kelly R Bales, Sharon M O'Neill, Nikolay Pozdnyakov, Feng Pan, David Caouette

Brain· February 2016

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A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.
Yuetiva Deming, Jian Xia, Yefei Cai, Jenny Lord, Peter Holmans, Kelly Bales

Neurobiol Aging· January 2016

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Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits.
Yuetiva Deming, Jian Xia, Yefei Cai, Jenny Lord, Jorge L Del-Aguila, Kelly Bales

Sci Rep· January 2016

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Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Todd W Butler, Christopher W Am Ende, Kelly R Bales

ACS Med Chem Lett· May 2015

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Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Edelweiss Evrard, Kelly R Bales

Bioorg Med Chem Lett· February 2015

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Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.
John S K Kauwe, Matthew H Bailey, Perry G Ridge, Rachel Perry, Mark E Wadsworth, Kelly Bales

PLoS Genet· October 2014

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Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid.
Oscar Harari, Carlos Cruchaga, John S K Kauwe, Benjamin J Ainscough, Kelly Bales

Biol Psychiatry· May 2014

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Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.
Martin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, Kelly R Bales, Christopher W am Ende

J Med Chem· February 2014

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Safety and pharmacology of a single intravenous dose of ponezumab in subjects with mild-to-moderate Alzheimer disease: a phase I, randomized, placebo-controlled, double-blind, dose-escalation study.
Jaren W Landen, Qinying Zhao, Sharon Cohen, Michael Borrie, Michael Woodward, Kelly Bales

Clin Neuropharmacol· October 2013

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γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.
Nikolay Pozdnyakov, Heather E Murrey, Christina J Crump, Martin Pettersson, T Eric Ballard, Kelly R Bales

J Biol Chem· April 2013

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Chronic administration of an aglycosylated murine antibody of ponezumab does not worsen microhemorrhages in aged Tg2576 mice.
Gary B Freeman, Thomas P Brown, Karin Wallace, Kelly R Bales

Curr Alzheimer Res· November 2012

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Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease.
Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Kelly Bales, Eve H Pickering

Hum Mol Genet· October 2012

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BMS-708,163 targets presenilin and lacks notch-sparing activity.
Christina J Crump, Suita V Castro, Feng Wang, Nikolay Pozdnyakov, T Eric Ballard, Kelly R Bales

Biochemistry· September 2012

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Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses.
Yasong Lu, David Riddell, Eva Hajos-Korcsok, Kelly Bales, Kathleen M Wood

J Pharmacol Exp Ther· August 2012

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Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.
Jesse M Hunter, John R Cirrito, Jessica L Restivo, Robert D Kinley, Patrick M Sullivan, Kelly Bales

Brain Res· July 2012

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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
Martin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, Kelly R Bales, Christopher W am Ende

Bioorg Med Chem Lett· April 2012

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The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update.
Kelly R Bales

Expert Opin Drug Discov· April 2012

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