Publications by authors named "David Riddell"

Claim this Profile
D
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
Brian T O'Neill, Elizabeth M Beck, Christopher R Butler, Charles E Nolan, Cathleen Gonzales, David Riddell

J Med Chem· May 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models.
Martine Latta-Mahieu, Bradford Elmer, Alexis Bretteville, Yaming Wang, Mati Lopez-Grancha, David R Riddell

Glia· March 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
Christopher R Butler, Kevin Ogilvie, Luis Martinez-Alsina, Gabriela Barreiro, Elizabeth M Beck, David Riddell

J Med Chem· January 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors.
Andrea M Zuhl, Charles E Nolan, Michael A Brodney, Sherry Niessen, Kevin Atchison, David R Riddell

Nat Commun· October 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.
Zdenek Berger, Sarah Perkins, Claude Ambroise, Christine Oborski, Matthew Calabrese, David Riddell

PLoS One· November 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
Michael A Brodney, Elizabeth M Beck, Christopher R Butler, Gabriela Barreiro, Eric F Johnson, David Riddell

J Med Chem· April 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
Christopher R Butler, Michael A Brodney, Elizabeth M Beck, Gabriela Barreiro, Charles E Nolan, David R Riddell

J Med Chem· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cerebrospinal fluid β-Amyloid turnover in the mouse, dog, monkey and human evaluated by systematic quantitative analyses.
Yasong Lu, Hugh A Barton, Louis Leung, Liming Zhang, Eva Hajos-Korcsok, David Riddell

Neurodegener Dis· January 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation.
Mihály Hajós, Elena Morozova, Chester Siok, Kevin Atchison, Charles E Nolan, David Riddell

Front Pharmacol· June 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses.
Yasong Lu, David Riddell, Eva Hajos-Korcsok, Kelly Bales, Kathleen M Wood

J Pharmacol Exp Ther· August 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Age-dependent disruption in hippocampal θ oscillation in amyloid-β overproducing transgenic mice.
Liam Scott, Jianlin Feng, Tamás Kiss, Elie Needle, Kevin Atchison, David Riddell

Neurobiol Aging· July 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
Antonia F Stepan, Chakrapani Subramanyam, Ivan V Efremov, Jason K Dutra, Theresa J O'Sullivan, David R Riddell

J Med Chem· April 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.
Yasong Lu, Liming Zhang, Charles E Nolan, Stacey L Becker, Kevin Atchison, David Riddell

J Pharmacol Exp Ther· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
Antonia F Stepan, Kapil Karki, W Scott McDonald, Peter H Dorff, Jason K Dutra, David Riddell

J Med Chem· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies.
Diana W Shineman, Guriqbal S Basi, Jennifer L Bizon, Carol A Colton, Barry D Greenberg, David R Riddell

Alzheimers Res Ther· September 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability.
Michael S Malamas, Albert Robichaud, Jim Erdei, Dominick Quagliato, William Solvibile, David Riddell

Bioorg Med Chem Lett· November 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Robert L Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z Xu, David R Riddell

J Pharmacol Exp Ther· November 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors.
Martin G Belinsky, Yuliya V Skorobogatko, Lori Rink, Jianming Pei, Kathy Q Cai, David Riddell

Genes Chromosomes Cancer· October 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
(
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Derek C Cole, Joseph R Stock, Anthony F Kreft, Madelene Antane, Suzan H Aschmies, David R Riddell

Bioorg Med Chem Lett· February 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Scott C Mayer, Anthony F Kreft, Boyd Harrison, Magid Abou-Gharbia, Madelene Antane, David R Riddell

J Med Chem· December 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.
David R Riddell, Hua Zhou, Kevin Atchison, Helen K Warwick, Peter J Atkinson

J Neurosci· November 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
ApoE promotes the proteolytic degradation of Abeta.
Qingguang Jiang, C Y Daniel Lee, Shweta Mandrekar, Brandy Wilkinson, Paige Cramer, David Riddell

Neuron· June 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
J Steven Jacobsen, Thomas A Comery, Robert L Martone, Hassan Elokdah, David L Crandall, David Riddell

Proc Natl Acad Sci U S A· June 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, David Riddell

Bioorg Med Chem Lett· February 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Paul Beswick, Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, David Riddell

Bioorg Med Chem Lett· February 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis