Publications by authors named "Kenneth Ellsworth"

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Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits.
Xinkang Wang, Stan Kurowski, Weizhen Wu, Gino A Castriota, Xueping Zhou, Kenneth P Ellsworth

J Pharmacol Exp Ther· March 2017

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Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
Ting Zhang, Yong Liu, Xianshu Yang, Gary E Martin, Huifang Yao, Kenneth P Ellsworth

J Med Chem· March 2016

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Development of a novel class of potent and selective FIXa inhibitors.
Ting Zhang, Patrick Andre, Thomas J Bateman, Yi-Heng Chen, Kunal Desai, Kenneth Ellsworth

Bioorg Med Chem Lett· November 2015

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Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Dongfang Meng, Patrick Andre, Thomas J Bateman, Richard Berger, Yi-Heng Chen, Kenneth Ellsworth

Bioorg Med Chem Lett· November 2015

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Rapid development of two factor IXa inhibitors from hit to lead.
Dann L Parker, Shawn Walsh, Bing Li, Esther Kim, Aurash Sharipour, Kenneth Ellsworth

Bioorg Med Chem Lett· June 2015

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Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.
Harry R Chobanian, Barbara Pio, Yan Guo, Hong Shen, Mark A Huffman, Kenneth Ellsworth

ACS Med Chem Lett· May 2015

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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Margaret Wu, Sheo B Singh, Jun Wang, Christine C Chung, Gino Salituro, Kenneth P Ellsworth

Proc Natl Acad Sci U S A· March 2011

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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Haifeng Tang, Yan Yan, Zhe Feng, Reynalda K de Jesus, Lihu Yang, Kenneth P Ellsworth

Bioorg Med Chem Lett· October 2010

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Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo.
Heather H Zhou, Chen-Ni Chin, Margaret Wu, Weihua Ni, Shuo Quan, Kenneth Ellsworth

Eur J Pharmacol· August 2009

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Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.
Chen-Ni Chin, Qing Dallas-Yang, Franklin Liu, Thu Ho, Kenneth Ellsworth

Eur J Pharmacol· March 2009

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Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.
Guoqiang Jiang, Zhihua Li, Franklin Liu, Kenneth Ellsworth, Qing Dallas-Yang

J Clin Invest· April 2005

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Modeling aided design of potent glycogen phosphorylase inhibitors.
Qiaolin Deng, Zhijian Lu, Joann Bohn, Kenneth P Ellsworth, Robert W Myers

J Mol Graph Model· April 2005

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Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.
Keith G Rosauer, Anthony K Ogawa, Chris A Willoughby, Kenneth P Ellsworth, Wayne M Geissler

Bioorg Med Chem Lett· December 2003

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A new class of glycogen phosphorylase inhibitors.
Zhijian Lu, Joann Bohn, Raynald Bergeron, Qiaolin Deng, Kenneth P Ellsworth

Bioorg Med Chem Lett· November 2003

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Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.
Anthony K Ogawa, Chris A Willoughby, Raynald Bergeron, Kenneth P Ellsworth, Wayne M Geissler

Bioorg Med Chem Lett· October 2003

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