Publications by authors named "Shawn Walsh"

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Stretching Peptides to Generate Small Molecule β-Strand Mimics.
Zoë C Adams, Anthony P Silvestri, Sorina Chiorean, Dillon T Flood, Brian P Balo, Shawn I Walsh

ACS Cent Sci· April 2023

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Initial Analysis of the Arylomycin D Antibiotics.
Yun Xuan Tan, David S Peters, Shawn I Walsh, Matthew Holcomb, Diogo Santos-Martins

J Nat Prod· July 2020

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Inhibition of Protein Secretion in and Sub-MIC Effects of Arylomycin Antibiotics.
Shawn I Walsh, David S Peters, Peter A Smith, Arryn Craney, Melissa M Dix

Antimicrob Agents Chemother· February 2019

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Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.
Chien-Hung Yeh, Shawn I Walsh, Arryn Craney, M Greg Tabor, Ana-Florina Voica

ACS Med Chem Lett· April 2018

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Inhibition of ROMK blocks macula densa tubuloglomerular feedback yet causes renal vasoconstriction in anesthetized rats.
Magali Araujo, William J Welch, Xiaoyan Zhou, Kathleen Sullivan, Shawn Walsh

Am J Physiol Renal Physiol· June 2017

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Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats.
Xiaoyan Zhou, Michael J Forrest, Wanda Sharif-Rodriguez, Gail Forrest, Daphne Szeto, Shawn P Walsh

Hypertension· February 2017

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Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence.
Shawn I Walsh, Arryn Craney, Floyd E Romesberg

Bioorg Med Chem· December 2016

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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Yuping Zhu, Reynalda K de Jesus, Haifeng Tang, Shawn P Walsh, Jinlong Jiang

Bioorg Med Chem Lett· December 2016

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Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
Haifeng Tang, Yuping Zhu, Nardos Teumelsan, Shawn P Walsh, Aurash Shahripour

ACS Med Chem Lett· July 2016

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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Reynalda K de Jesus, Nardos Teumelsan

Bioorg Med Chem Lett· May 2016

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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Nardos Teumelsan, Jessica Frie

ACS Med Chem Lett· July 2015

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Rapid development of two factor IXa inhibitors from hit to lead.
Dann L Parker, Shawn Walsh, Bing Li, Esther Kim, Aurash Sharipour

Bioorg Med Chem Lett· June 2015

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Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes.
Tadayuki Tsujita, Vivian Peirce, Liam Baird, Yuka Matsuyama, Misaki Takaku, Shawn V Walsh

Mol Cell Biol· October 2014

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Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Haifeng Tang, Reynald K de Jesus, Shawn P Walsh, Yuping Zhu, Yan Yan

Bioorg Med Chem Lett· November 2013

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Total synthesis of (+)-irciniastatin A (a.k.a. psymberin) and (-)-irciniastatin B.
Chihui An, Jon A Jurica, Shawn P Walsh, Adam T Hoye, Amos B Smith

J Org Chem· May 2013

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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.
Haifeng Tang, Shawn P Walsh, Yan Yan, Reynalda K de Jesus, Aurash Shahripour

ACS Med Chem Lett· May 2012

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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.
Shawn P Walsh, Alexandra Severino, Changyou Zhou, Jiafang He, Gui-Bai Liang

Bioorg Med Chem Lett· June 2011

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Total synthesis of (+)-psymberin (irciniastatin A): catalytic reagent control as the strategic cornerstone.
Amos B Smith, Jon A Jurica, Shawn P Walsh

Org Lett· December 2008

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Total syntheses of the assigned structures of lituarines B and C.
Amos B Smith, Matthew O Duffey, Kallol Basu, Shawn P Walsh, Hans W Suennemann

J Am Chem Soc· January 2008

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Diversity-oriented synthesis of polyketide natural products via iterative chemo- and stereoselective functionalization of polyenoates: development of a unified approach for the C(1-19) segments of lituarines A-C.
Amos B Smith, Shawn P Walsh, Michael Frohn, Matthew O Duffey

Org Lett· January 2005

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Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.
Weiqin Jiang, Zhihua Sui, Mark J Macielag, Shawn P Walsh, James J Fiordeliso

J Med Chem· January 2003

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Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics.
Andrew L Folpe, Steven D Billings, Jesse K McKenney, Shawn V Walsh, Asma Nusrat

Am J Surg Pathol· December 2002

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