Publications by authors named "Kenneth Macleod"

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Humanization of Drug Metabolism in the Mouse Model for Antimalarial Drug Discovery.
A Kenneth MacLeod, Cristina Merino, Sara Viera-Morilla, Laura Frame, Amy Tavendale

ACS Infect Dis· December 2025

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Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor.
Ed J Griffen, Daren Fearon, Briana L McGovern, Lizbe Koekemoer, Blake H Balcomb, A Kenneth MacLeod

bioRxiv· June 2025

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E-Cigarette Education and Training in Medical Schools: A National Survey.
Ross J Langley, Holly Hamilton, Steve Turner, Elizabeth Watt, Frankie Posner, Kenneth A Macleod

Pediatr Pulmonol· May 2025

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Vaping: Harm Reduction or Chucking Children under the Bus?
Andrew Bush, Jonathan Coutts, Ross Langley, Kenneth Macleod

Br J Hosp Med (Lond)· March 2025

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Whole genome sequencing enhances molecular diagnosis of primary ciliary dyskinesia.
Holly A Black, Sophie Marion de Proce, Jose L Campos, Alison Meynert, Mihail Halachev, Kenneth Macleod

Pediatr Pulmonol· December 2024

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Lung clearance index (LCI) changes after initiation of Elexacaftor/Tezacaftor/Ivacaftor in children with cystic fibrosis aged between 6 and 11 years: The "real-world" differs from trial data.
Don S Urquhart, Heather Dowle, Kellie Moffat, Jody Forster, Steve Cunningham, Kenneth A Macleod

Pediatr Pulmonol· May 2024

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Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules.
Daniel O Dodd, Sabrina Mechaussier, Patricia L Yeyati, Fraser McPhie, Jacob R Anderson, Kenneth A Macleod

Science· April 2024

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Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
A Kenneth MacLeod, Kevin-Sebastien Coquelin, Leticia Huertas, Frederick R C Simeons, Jennifer Riley

Proc Natl Acad Sci U S A· February 2024

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Retrospective cohort analysis of weight changes during the COVID-19 pandemic in a pediatric asthma population.
Cari O'Rourke, Philippa Wood, Kenneth A Macleod, Julie Westwood, Don S Urquhart

J Asthma· December 2023

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Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells.
Nicola Dark, Marie-Victoire Cosson, Lorenza I Tsansizi, Thomas J Owen, Elisa Ferraro, Kenneth T MacLeod

Cell Rep Methods· April 2023

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Changes in cellular Ca and Na regulation during the progression towards heart failure.
Kenneth T MacLeod

J Physiol· March 2023

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Variation in IL6ST cytokine family function and the potential of IL6 trans-signalling in ERα positive breast cancer cells.
Duniya Mosly, Kenneth MacLeod, Nicholas Moir, Arran Turnbull, Andrew H Sims

Cell Signal· March 2023

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Co-exposure to urban particulate matter and aircraft noise adversely impacts the cerebro-pulmonary-cardiovascular axis in mice.
Marin Kuntic, Ivana Kuntic, Roopesh Krishnankutty, Adrian Gericke, Matthias Oelze, Kenneth G Macleod

Redox Biol· February 2023

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High-speed 2D light-sheet fluorescence microscopy enables quantification of spatially varying calcium dynamics in ventricular cardiomyocytes.
Liuba Dvinskikh, Hugh Sparks, Kenneth T MacLeod, Chris Dunsby

Front Physiol· February 2023

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The PhanSST global database of Phanerozoic sea surface temperature proxy data.
Emily J Judd, Jessica E Tierney, Brian T Huber, Scott L Wing, Daniel J Lunt, Kenneth G MacLeod

Sci Data· December 2022

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Protecting children from harms of vaping.
Kenneth Macleod, Andy Bush, Jonathan Coutts, Ross Langley

BMJ· December 2022

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GPER limits adverse changes to Ca signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes.
Alice J Francis, Jahn M Firth, Jose L Sanchez-Alonso, Julia Gorelik, Kenneth T MacLeod

Front Physiol· November 2022

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Control of cell state transitions.
Oleksii S Rukhlenko, Melinda Halasz, Nora Rauch, Vadim Zhernovkov, Thomas Prince, Kenneth MacLeod

Nature· September 2022

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Integrins Increase Sarcoplasmic Reticulum Activity for Excitation-Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes.
Brian X Wang, Christopher Kane, Laura Nicastro, Oisín King, Worrapong Kit-Anan, Kenneth T MacLeod

Int J Mol Sci· September 2022

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Biotic and Paleoceanographic Changes Across the Late Cretaceous Oceanic Anoxic Event 2 in the Southern High Latitudes (IODP Sites U1513 and U1516, SE Indian Ocean).
Maria Rose Petrizzo, Giulia Amaglio, David K Watkins, Kenneth G MacLeod, Brian T Huber

Paleoceanogr Paleoclimatol· September 2022

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OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.
Louise M Hesketh, Markus B Sikkel, Laura Mahoney-Sanchez, Francesca Mazzacuva, Rasheda A Chowdhury, Kenneth T MacLeod

Br J Pharmacol· May 2022

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Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment.
John C Dawson, Alison Munro, Kenneth Macleod, Morwenna Muir, Paul Timpson

Mol Oncol· March 2022

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Extracellular Vesicles from Human Cardiac Fibroblasts Modulate Calcium Cycling in Human Stem Cell-Derived Cardiomyocytes.
Brian X Wang, Laura Nicastro, Liam Couch, Worrapong Kit-Anan, Barrett Downing, Kenneth T MacLeod

Cells· March 2022

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Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα, and cell-cycle signaling in a breast cancer model.
Kate M Moore, Vera Cerqueira, Kenneth G MacLeod, Peter Mullen, Richard L Hayward

Explor Target Antitumor Ther· February 2022

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Late Cretaceous Paleoceanographic Evolution and the Onset of Cooling in the Santonian at Southern High Latitudes (IODP Site U1513, SE Indian Ocean).
Maria Rose Petrizzo, Kenneth G MacLeod, David K Watkins, Erik Wolfgring, Brian T Huber

Paleoceanogr Paleoclimatol· January 2022

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