Publications by authors named "Kenneth N MacLean"

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Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia.
Michael A Swanson, Hua Jiang, Nicolas Busquet, Jessica Carlsen, Connie Brindley, Kenneth N MacLean

J Inherit Metab Dis· September 2024

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Dysregulation of hepatic one-carbon metabolism in classical homocystinuria: Implications of redox-sensitive DHFR repression and tetrahydrofolate depletion for pathogenesis and treatment.
Kenneth N Maclean, Hua Jiang, Philip D Neill, Ryan R Chanin, K Joseph Hurt

FASEB J· July 2024

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Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia.
Michael A Swanson, Hua Jiang, Nicolas Busquet, Jessica Carlsen, Connie Brindley, Kenneth N MacLean

bioRxiv· March 2024

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Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.
Tamana R Yousof, Celeste C Bouchard, Mihnea Alb, Edward G Lynn, Sárka Lhoták, Kenneth N Maclean

J Biol Chem· February 2024

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Characterization of mitochondrial and metabolic alterations induced by trisomy 21 during neural differentiation.
Kendra M Prutton, John O Marentette, Kenneth N Maclean, James R Roede

Free Radic Biol Med· February 2023

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Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.
Kendra M Prutton, John O Marentette, Brice A Leifheit, Hector Esquer, Daniel V LaBarbera, Kenneth N Maclean

Free Radic Biol Med· June 2022

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Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism.
Colin C Anderson, John O Marentette, Kendra M Prutton, Abhishek K Rauniyar, Julie A Reisz, Kenneth N Maclean

Free Radic Biol Med· August 2021

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Analysis of differential neonatal lethality in cystathionine β-synthase deficient mouse models using metabolic profiling.
Sapna Gupta, Liqun Wang, Michael J Slifker, Kathy Q Cai, Kenneth N Maclean

FASEB J· June 2021

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Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis.
Rachael Bok, Damian D Guerra, Ramón A Lorca, Sara A Wennersten, Peter S Harris, Kenneth N MacLean

Redox Biol· April 2021

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Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Kenneth N Maclean, Hua Jiang, Whitney N Phinney, Bailey M Mclagan, James R Roede

Mol Genet Metab· February 2021

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Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium.
Damian D Guerra, Rachael Bok, Kelsey Breen, Vibhuti Vyas, Hua Jiang, Kenneth N MacLean

Reprod Sci· January 2021

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Maternal Amino Acid Profiles to Distinguish Constitutionally Small versus Growth-Restricted Fetuses Defined by Doppler Ultrasound: A Pilot Study.
Anne C Porter, Diane L Gumina, Michael Armstrong, Kenneth N Maclean, Nichole Reisdorph

Am J Perinatol· September 2020

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Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease.
Marisa W Friederich, Abdallah F Elias, Alice Kuster, Lucia Laugwitz, Austin A Larson, Kenneth N MacLean

J Inherit Metab Dis· September 2020

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SNARE proteins rescue impaired autophagic flux in Down syndrome.
Stefanos Aivazidis, Abhilasha Jain, Abhishek K Rauniyar, Colin C Anderson, John O Marentette, Kenneth N Maclean

PLoS One· March 2020

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knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice.
Paul F Lebeau, Jae Hyun Byun, Khrystyna Platko, Ali A Al-Hashimi, Šárka Lhoták, Kenneth N Maclean

JHEP Rep· December 2019

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GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury.
Khrystyna Platko, Paul F Lebeau, Jae Hyun Byun, Samantha V Poon, Emily A Day, Kenneth N Maclean

Mol Metab· September 2019

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Taurine alleviates repression of betaine-homocysteine -methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria.
Kenneth N Maclean, Hua Jiang, Whitney N Phinney, Amy K Keating, K Joseph Hurt

FASEB J· May 2019

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Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.
Johan L K Van Hove, Cynthia L Freehauf, Can Ficicioglu, Loren D M Pena, Kerrie L Moreau, Kenneth N MacLean

J Inherit Metab Dis· May 2019

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Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.
Stephanie R Wesolowski, Christopher M Mulligan, Rachel C Janssen, Peter R Baker, Bryan C Bergman, Kenneth N Maclean

Mol Metab· December 2018

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Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.
Kenneth N Maclean, Hua Jiang, Stefanos Aivazidis, Eugene Kim, Colin T Shearn

FASEB J· March 2018

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Methylene-tetrahydrofolate reductase contributes to allergic airway disease.
Kenneth R Eyring, Brent S Pedersen, Kenneth N Maclean, Sally P Stabler, Ivana V Yang

PLoS One· February 2018

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The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.
Stefanos Aivazidis, Christina M Coughlan, Abhishek K Rauniyar, Hua Jiang, L Alexander Liggett, Kenneth N Maclean

PLoS One· September 2017

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Erratum: A 2.78-Mb duplication on chromosome 21q22.11 implicates candidate genes in the partial trisomy 21 phenotype.
James D Weisfeld-Adams, Amanda K Tkachuk, Kenneth N Maclean, Naomi L Meeks, Stuart A Scott

NPJ Genom Med· August 2017

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Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.
René L Jacobs, Hua Jiang, John P Kennelly, David J Orlicky, Robert H Allen, Kenneth N Maclean

Mol Genet Metab· April 2017

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A 2.78-Mb duplication on chromosome 21q22.11 implicates candidate genes in the partial trisomy 21 phenotype.
James D Weisfeld-Adams, Amanda K Tkachuk, Kenneth N Maclean, Naomi L Meeks, Stuart A Scott

NPJ Genom Med· March 2016

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