Publications by authors named "Kenneth Rohrbach"

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Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.
Saleem Ahmad, William N Washburn, Andres S Hernandez, Sharon Bisaha, Khehyong Ngu, Kenneth Rohrbach

J Med Chem· October 2016

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Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies.
Pratik Devasthale, Wei Wang, James Mignone, Kishore Renduchintala, Sridhar Radhakrishnan, Kenneth Rohrbach

Bioorg Med Chem Lett· October 2015

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Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup.
Pratik Devasthale, Wei Wang, Andres S Hernandez, Fang Moore, Kishore Renduchintala, Kenneth Rohrbach

Bioorg Med Chem Lett· July 2015

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Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.
William N Washburn, Mark Manfredi, Pratik Devasthale, Guohua Zhao, Saleem Ahmad, Kenneth Rohrbach

J Med Chem· September 2014

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Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats.
Yu-Wen Li, Shaun Langdon, Rick Pieschl, Todd Strong, Robert N Wright, Kenneth Rohrbach

Eur J Pharmacol· August 2014

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Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.
Bruce A Ellsworth, Philip M Sher, Ximao Wu, Gang Wu, Richard B Sulsky, Kenneth W Rohrbach

J Med Chem· December 2013

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Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.
Guohua Zhao, Chet Kwon, Sharon N Bisaha, Philip D Stein, Karen A Rossi, Kenneth W Rohrbach

Bioorg Med Chem Lett· July 2013

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Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
John M Fevig, Jianxin Feng, Karen A Rossi, Keith J Miller, Ginger Wu, Kenneth W Rohrbach

Bioorg Med Chem Lett· January 2013

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Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.
Yifan Yang, Keith J Miller, Yeheng Zhu, Yang Hong, Yuan Tian, Kenneth W Rohrbach

Bioorg Med Chem Lett· November 2011

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Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.
Saleem Ahmad, Khehyong Ngu, Keith J Miller, Ginger Wu, Chen-pin Hung, Kenneth W Rohrbach

Bioorg Med Chem Lett· February 2010

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Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
Dean A Wacker, Jeffrey G Varnes, Sarah E Malmstrom, Xueying Cao, Chen-Pin Hung, Kenneth W Rohrbach

J Med Chem· March 2007

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Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents.
Kenneth W Rohrbach, Songping Han, Jinping Gan, Eva J O'Tanyi, Hongwei Zhang

Eur J Pharmacol· March 2005

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