Publications by authors named "Kevin Read"

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Humanization of Drug Metabolism in the Mouse Model for Antimalarial Drug Discovery.
A Kenneth MacLeod, Cristina Merino, Sara Viera-Morilla, Laura Frame, Amy Tavendale, Kevin D Read

ACS Infect Dis· December 2025

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Targeting dihydroorotate dehydrogenase (DHODH) for host-directed therapy: Discovery of a novel alkyne-based scaffold inhibitor effective against SARS-CoV-2.
Miguel M Vaidergorn, Aline D Purificação, Pedro I P Leite, Sabrina Silva-Mendonça, Wemenes J L Silva, Kevin D Read

Eur J Med Chem· November 2025

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Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.
Yury Kapelyukh, Charlotte Gabel-Jensen, Alastaire Kenneth MacLeod, Kevin-Sebastien Daniel Coquelin, Laste Stojanovski, Kevin D Read

Drug Metab Dispos· October 2025

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Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening.
Andreas Holmqvist, Nur Mehpare Kocaturk, Christina Duncan, Jennifer Riley, Steven Baginski, Kevin D Read

Nat Commun· October 2025

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Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.
Susan H Davis, Michael Mathieson, Kirsteen I Buchanan, Alice Dawson, Alasdair Smith, Kevin D Read

J Med Chem· August 2025

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Computationally guided optimization of the antimalarial activity and physicochemical properties of 2,4-diaminopyrimidines.
Guntur Guntur, Duangkamol Gleeson, Mark Anderson, Nicole Mutter, Lauren Webster, Kevin D Read

RSC Med Chem· August 2025

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Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation.
Janine L Gray, Elizabeth V K Ledger, Tiffany Suwatthee, Thomas J Burden, Konstantina Arvaniti, Kevin D Read

bioRxiv· August 2025

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High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer.
Laura Aitken, Gemma Baillie, Andrew Pannifer, Angus Morrison, Louise L Major, Kevin D Read

ACS Chem Biol· July 2025

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Structure-activity relationships of 1,5-dihydro-2-benzo[][1,4]diazepine-2,4(3)-diones as inhibitors of .
Michael G Thomas, Joanne Dunne, Peter G Dodd, Emiliana D'Oria, Laura Frame, Kevin D Read

RSC Med Chem· June 2025

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Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor.
Ed J Griffen, Daren Fearon, Briana L McGovern, Lizbe Koekemoer, Blake H Balcomb, Kevin D Read

bioRxiv· June 2025

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Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of .
Simon R Green, Justin R Harrison, Stephen Thompson, Dinakaran Murugesan, M Daben J Libardo, Kevin D Read

ACS Infect Dis· March 2025

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Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signaling.
Vasudha Tandon, Alessandra Fistrovich, Joaquina Nogales, Febe Ferro, Samantha N Rokey, Kevin D Read

bioRxiv· March 2025

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Use of an extensively humanized mouse model to predict the risk of drug-drug interactions in patients receiving dexamethasone.
Jacob George, James D Chalmers, Kevin-Sebastien Coquelin, Laura Frame, Colin J Henderson, Kevin D Read

J Pharmacol Exp Ther· February 2025

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Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against and , Two Emerging Human Pathogens.
Matheus Andrade Meirelles, Vitor M Almeida, Jaryd R Sullivan, Ian de Toledo, Caio Vinicius Dos Reis, Kevin D Read

J Med Chem· November 2024

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lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.
Nicola Caldwell, Caroline Peet, Peter Miller, Beatrice L Colon, Malcolm G Taylor, Kevin D Read

Sci Transl Med· October 2024

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Log D and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity.
Andrew M Brandon, Steven R Baginski, Caroline Peet, Pat Dugard, Henrik Green, Kevin D Read

Drug Test Anal· September 2024

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Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
A Kenneth MacLeod, Kevin-Sebastien Coquelin, Leticia Huertas, Frederick R C Simeons, Jennifer Riley, Kevin D Read

Proc Natl Acad Sci U S A· February 2024

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Sperm Toolbox-A selection of small molecules to study human spermatozoa.
Franz S Gruber, Anthony Richardson, Zoe C Johnston, Rachel Myles, Neil R Norcross, Kevin D Read

PLoS One· February 2024

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Short-course combination treatment for experimental chronic Chagas disease.
Silvia González, Richard J Wall, John Thomas, Stephanie Braillard, Gino Brunori, Kevin D Read

Sci Transl Med· December 2023

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Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
Simon R Green, Caroline Wilson, Thomas C Eadsforth, Avinash S Punekar, Fabio K Tamaki, Kevin D Read

J Med Chem· November 2023

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Correction to "Bespoke Drug Discovery Training for Low-Middle Income Countries".
Lauren A Webster, Susan J Farrell, Ian H Gilbert, Paul G Wyatt, Kevin D Read

ACS Med Chem Lett· November 2023

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Structure-Guided Design and Synthesis of a Pyridazinone Series of Proteasome Inhibitors.
Michael G Thomas, Kate McGonagle, Paul Rowland, David A Robinson, Peter G Dodd, Kevin D Read

J Med Chem· August 2023

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Bespoke Drug Discovery Training for Low-Middle Income Countries.
Lauren A Webster, Susan J Farrell, Ian H Gilbert, Kevin D Read

ACS Med Chem Lett· August 2023

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Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Kevin D Read

J Med Chem· July 2023

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Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Susan Wyllie, Michael Thomas, Stephen Patterson, Sabrinia Crouch, Manu De Rycker, Kevin D Read

Nature· July 2023

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