Publications by authors named "Kevin Trouba"

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Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Hsiao-Tzu Chien, Helen Prior, Laura Andrews, Leon van Aerts, Annick Cauvin, Kevin Trouba

Regul Toxicol Pharmacol· February 2023

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The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Helen Prior, Laura Andrews, Annick Cauvin, Hsiaotzu Chien, David O Clarke, Kevin Trouba

Regul Toxicol Pharmacol· February 2023

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Discovery and pharmacological characterization of cetrelimab (JNJ-63723283), an anti-programmed cell death protein-1 (PD-1) antibody, in human cancer models.
Nikki DeAngelis, Catherine Ferrante, Gordon Powers, Jocelyn Sendecki, Bethany Mattson, Kevin Trouba

Cancer Chemother Pharmacol· April 2022

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An IQ Consortium Perspective on The Scientific Committee on Health, Environmental and Emerging Risks Final Opinion on the Need for Nonhuman Primates in Biomedical Research, Production and Testing of Products and Devices (Update 2017).
Khary Adams, Donna Clemons, Lynn Collura Impelluso, Donna Lee, Sean Maguire, Kevin Trouba

Toxicol Pathol· July 2019

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In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094 : Potential Role in Clinical Cardiovascular Toxicity.
Wenying Li, Kevin J Trouba, Li Ma, Jae Kwagh, Christopher Storck

Int J Toxicol· January 2017

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Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.
Ang Liu, John Lute, Huidong Gu, Bonnie Wang, Kevin J Trouba

J Chromatogr B Analyt Technol Biomed Life Sci· September 2015

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Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum.
Yue Zhao, Guowen Liu, Aida Angeles, Lora L Hamuro, Kevin J Trouba

J Chromatogr B Analyt Technol Biomed Life Sci· April 2015

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Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.
Naiyu Zheng, Jianing Zeng, Qin C Ji, Aida Angeles, Adela Buzescu, Kevin Trouba

J Pharm Biomed Anal· February 2014

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A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.
Naiyu Zheng, Jianing Zeng, Billy Akinsanya, Adela Buzescu, Yuan-Qing Xia, Kevin Trouba

J Pharm Biomed Anal· September 2013

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Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies.
Evan A Thackaberry, Stephen Kopytek, Phillip Sherratt, Kevin Trouba, Barry McIntyre

Toxicol Sci· October 2010

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A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Laurie Scott, Chantra Eskes, Sebastian Hoffmann, Els Adriaens, Nathalie Alepée, Kevin Trouba

Toxicol In Vitro· February 2010

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Arsenic-induced alterations in the contact hypersensitivity response in Balb/c mice.
Rachel Patterson, Libia Vega, Kevin Trouba, Carl Bortner, Dori Germolec

Toxicol Appl Pharmacol· August 2004

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Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice.
Yaxiong Xie, Kevin J Trouba, Jie Liu, Michael P Waalkes, Dori R Germolec

Environ Health Perspect· August 2004

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Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes.
Hisham K Hamadeh, Kevin J Trouba, Rupesh P Amin, Cynthia A Afshari, Dori Germolec

Toxicol Sci· October 2002

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Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes.
Kevin J Trouba, Kristen M Geisenhoffer, Dori R Germolec

Environ Health Perspect· October 2002

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Oxidative stress and its role in skin disease.
Kevin J Trouba, Hisham K Hamadeh, Rupesh P Amin, Dori R Germolec

Antioxid Redox Signal· August 2002

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