Publications by authors named "Kimberly Straley"

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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.
Zenon Konteatis, Erin Artin, Brandon Nicolay, Kimberly Straley, Anil K Padyana

ACS Med Chem Lett· February 2020

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Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia.
Andrew M Brunner, Donna S Neuberg, Seth A Wander, Hossein Sadrzadeh, Karen K Ballen, Kimberly Straley

Cancer· February 2019

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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.
Janeta Popovici-Muller, René M Lemieux, Erin Artin, Jeffrey O Saunders, Francesco G Salituro, Kimberly Straley

ACS Med Chem Lett· April 2018

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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic Mutations.
Katharine Yen, Jeremy Travins, Fang Wang, Muriel D David, Erin Artin, Kimberly Straley

Cancer Discov· May 2017

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A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
Fang Wang, Jeremy Travins, Zhizhong Lin, Yaguang Si, Yue Chen, Kimberly Straley

J Inherit Metab Dis· November 2016

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Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Satoshi Inoue, Wanda Y Li, Alan Tseng, Isabel Beerman, Andrew J Elia, Kimberly Straley

Cancer Cell· August 2016

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Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.
Macarena I de la Fuente, Robert J Young, Jennifer Rubel, Marc Rosenblum, Jamie Tisnado, Kimberly Straley

Neuro Oncol· February 2016

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Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.
Zhenyue Hao, Rob A Cairns, Satoshi Inoue, Wanda Y Li, Yi Sheng, Kimberly S Straley

Proc Natl Acad Sci U S A· February 2016

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Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Supriya K Saha, Christine A Parachoniak, Krishna S Ghanta, Julien Fitamant, Kenneth N Ross, Kimberly S Straley

Nature· December 2015

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Mutant IDH is sufficient to initiate enchondromatosis in mice.
Makoto Hirata, Masato Sasaki, Rob A Cairns, Satoshi Inoue, Vijitha Puviindran, Kimberly Straley

Proc Natl Acad Sci U S A· March 2015

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IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.
Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley

Blood· January 2015

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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.
Supriya K Saha, Christine A Parachoniak, Krishna S Ghanta, Julien Fitamant, Kenneth N Ross, Kimberly S Straley

Nature· September 2014

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Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.
Amir T Fathi, Hossein Sadrzadeh, Amy H Comander, Michaela J Higgins, Aditya Bardia, Kimberly S Straley

Oncologist· June 2014

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Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
Mindy I Davis, Stefan Gross, Min Shen, Kimberly S Straley, Rajan Pragani

J Biol Chem· May 2014

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Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.
Darrell R Borger, Lipika Goyal, Thomas Yau, Ronnie T Poon, Marek Ancukiewicz, Kimberly S Straley

Clin Cancer Res· April 2014

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Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
Lev M Kats, Markus Reschke, Riccardo Taulli, Olga Pozdnyakova, Kerri Burgess, Kimberly Straley

Cell Stem Cell· March 2014

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Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia.
Courtney D DiNardo, Kathleen J Propert, Alison W Loren, Elisabeth Paietta, Zhuoxin Sun, Kimberly S Straley

Blood· June 2013

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
Fang Wang, Jeremy Travins, Byron DeLaBarre, Virginie Penard-Lacronique, Stefanie Schalm, Kimberly Straley

Science· May 2013

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2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.
Daniel A Pollyea, Holbrook E Kohrt, Bing Zhang, James Zehnder, David Schenkein, Kimberly Straley

Leuk Lymphoma· February 2013

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Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response.
Amir T Fathi, Hossein Sadrzadeh, Darrell R Borger, Karen K Ballen, Philip C Amrein, Kimberly S Straley

Blood· November 2012

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Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.
Janeta Popovici-Muller, Jeffrey O Saunders, Francesco G Salituro, Jeremy M Travins, Shunqi Yan, Kimberly S Straley

ACS Med Chem Lett· October 2012

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Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
Darrell R Borger, Kenneth K Tanabe, Kenneth C Fan, Hector U Lopez, Valeria R Fantin, Kimberly S Straley

Oncologist· June 2012

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Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.
Fredrick Van Goor, Sabine Hadida, Peter D J Grootenhuis, Bill Burton, Jeffrey H Stack, Kimberly S Straley

Proc Natl Acad Sci U S A· November 2011

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Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.
M Fernanda Amary, Stephen Damato, Dina Halai, Malihe Eskandarpour, Fitim Berisha, Kimberly S Straley

Nat Genet· November 2011

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