Publications by authors named "Kosea Frederick"

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Pharmacodynamic effects of highly selective aldosterone synthase inhibitor vicadrostat in cynomolgus monkeys: Contrasting effects of once versus twice daily dosing.
Steven M Weldon, Derek A Cogan, Matthew A Cerny, Kosea S Frederick, Kristina K Gueneva-Boucheva

J Pharmacol Exp Ther· August 2025

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Indinavir Increases Midazolam -Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach.
Dan-Dan Tian, Cathrine Leonowens, Emily J Cox, Vanessa González-Pérez, Kosea S Frederick

Drug Metab Dispos· July 2019

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Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.
Diane Ramsden, Dustin Smith, Raquel Arenas, Kosea Frederick, Matthew A Cerny

Drug Metab Dispos· October 2018

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Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.
Kenneth Meyers, Derek A Cogan, Jennifer Burke, Raquel Arenas, Michael Balestra, Kosea S Frederick

Bioorg Med Chem Lett· March 2018

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Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.
Matthew A Cerny, Alexander Csengery, Jennifer Schmenk, Kosea Frederick

J Steroid Biochem Mol Biol· November 2015

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Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.
J Matthew Hutzler, Matthew A Cerny, Young-Sun Yang, Constance Asher, Diane Wong, Kosea Frederick

Drug Metab Dispos· October 2014

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Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility.
Amit S Kalgutkar, Kosea S Frederick, Heather L Hatch, Catherine M Ambler, David A Perry

Xenobiotica· July 2014

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Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Amit S Kalgutkar, Danny Chen, Manthena V Varma, Bo Feng, Steven G Terra, Kosea S Frederick

Xenobiotica· November 2013

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Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Samit K Bhattacharya, Gary E Aspnes, Scott W Bagley, Markus Boehm, Arthur D Brosius, Kosea S Frederick

Bioorg Med Chem Lett· December 2012

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Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Amit S Kalgutkar, David A Griffith, Tim Ryder, Hao Sun, Zhuang Miao, Kosea S Frederick

Chem Res Toxicol· June 2010

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CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) mice.
Robert J Aiello, Bret D Perry, Patricia-Ann Bourassa, Andrew Robertson, Weifan Weng, Kosea S Frederick

Atherosclerosis· February 2010

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N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.
Amit S Kalgutkar, Kosea S Frederick, Jonathan Chupka, Bo Feng, Sarah Kempshall

J Pharm Sci· December 2009

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Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists.
Mary T Didiuk, David A Griffith, John W Benbow, Kevin K C Liu, Daniel P Walker, Kosea S Frederick

Bioorg Med Chem Lett· August 2009

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Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.
Jonathan N Bauman, Kosea S Frederick, Aarti Sawant, Robert L Walsky, Loretta M Cox

Drug Metab Dispos· June 2008

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Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and human.
Amit S Kalgutkar, Bo Feng, Hang T Nguyen, Kosea S Frederick, Scott D Campbell

Drug Metab Dispos· November 2007

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NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Sabrina X Zhao, Deepak K Dalvie, Joan M Kelly, John R Soglia, Kosea S Frederick

Chem Res Toxicol· November 2007

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Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Amit S Kalgutkar, Heather L Hatch, Frederick Kosea, Hang T Nguyen, Edna F Choo

Biopharm Drug Dispos· November 2006

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Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats.
Young Jin Moon, Kazuko Sagawa, Kosea Frederick, Shuzhong Zhang, Marilyn E Morris

AAPS J· July 2006

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