Publications by authors named "Steven M Weldon"

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Pharmacodynamic effects of highly selective aldosterone synthase inhibitor vicadrostat in cynomolgus monkeys: Contrasting effects of once versus twice daily dosing.
Steven M Weldon, Derek A Cogan, Matthew A Cerny, Kosea S Frederick, Kristina K Gueneva-Boucheva

J Pharmacol Exp Ther· August 2025

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Impact of Dietary Sodium Reduction on the Development of Obesity and Type 2 Diabetes in db/db Mice.
Anja Hofmann, Coy Brunssen, Mirko Peitzsch, Jennifer Mittag, Annika Frenzel, Steven M Weldon

Horm Metab Res· October 2021

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In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.
Brian Leei Lin, Damian Matera, Julia F Doerner, Nan Zheng, Donato Del Camino, Steven M Weldon

Proc Natl Acad Sci U S A· May 2019

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Inhibitors of Aldosterone Synthase.
Steven M Weldon, Nicholas F Brown

Vitam Horm· April 2019

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Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.
Kenneth Meyers, Derek A Cogan, Jennifer Burke, Raquel Arenas, Michael Balestra, Steven M Weldon

Bioorg Med Chem Lett· March 2018

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Impact of Aldosterone Synthase Inhibitor FAD286 on Steroid Hormone Profile in Human Adrenocortical Cells.
Coy Brunssen, Anja Hofmann, Mirko Peitzsch, Annika Frenzel, Christian G Ziegler, Steven M Weldon

Horm Metab Res· September 2017

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The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice.
Anja Hofmann, Coy Brunssen, Mirko Peitzsch, Mariya Balyura, Jennifer Mittag, Steven M Weldon

Horm Metab Res· June 2017

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Elevated Steroid Hormone Production in the db/db Mouse Model of Obesity and Type 2 Diabetes.
Anja Hofmann, Mirko Peitzsch, Coy Brunssen, Jennifer Mittag, Annett Jannasch, Steven M Weldon

Horm Metab Res· January 2017

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Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase.
Christin Boldt, Tom Röschel, Nina Himmerkus, Allein Plain, Markus Bleich, Steven M Weldon

Am J Physiol Renal Physiol· December 2016

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Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates.
Steven M Weldon, Matthew A Cerny, Kristina Gueneva-Boucheva, Derek Cogan, Xin Guo

J Pharmacol Exp Ther· October 2016

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Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats.
Anja Hofmann, Coy Brunssen, Mirko Peitzsch, Melanie Martin, Jennifer Mittag, Steven M Weldon

Endocrinology· October 2016

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Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.
Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner, Steven M Weldon

PLoS One· July 2016

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GDF11 does not rescue aging-related pathological hypertrophy.
Shavonn C Smith, Xiaoxiao Zhang, Xiaoying Zhang, Polina Gross, Timothy Starosta, Steven M Weldon

Circ Res· November 2015

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Novel soluble epoxide hydrolase inhibitor protects mitochondrial function following stress.
Sri N Batchu, Stephen B Lee, Victor Samokhvalov, Ketul R Chaudhary, Haitham El-Sikhry, Steven M Weldon

Can J Physiol Pharmacol· June 2012

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Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation.
Rebecca L Charles, Joseph R Burgoyne, Manuel Mayr, Steven M Weldon, Norbert Hubner

Circ Res· February 2011

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Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice.
Hantz C Hercule, Wolf-Hagen Schunck, Volkmar Gross, Jasmin Seringer, Fung Ping Leung, Steven M Weldon

Arterioscler Thromb Vasc Biol· January 2009

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Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Jan Monti, Judith Fischer, Svetlana Paskas, Matthias Heinig, Herbert Schulz, Steven M Weldon

Nat Genet· May 2008

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Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice.
Ayala Luria, Steven M Weldon, Alisa K Kabcenell, Richard H Ingraham, Damian Matera

J Biol Chem· February 2007

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Daniel Lamarre, Paul C Anderson, Murray Bailey, Pierre Beaulieu, Gordon Bolger, Steven M Weldon

Nature· November 2003

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