Publications by authors named "Kyle Trudeau"

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In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles.
Vladimir V Botchkarev, Sean Harrington, Matteo Stoppato, Alexander Justen, Casey Kimber, Kyle Trudeau

Nat Biotechnol· December 2025

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In vivo chimeric antigen receptor (CAR)-T cell therapy.
Adrian Bot, Andrew Scharenberg, Kevin Friedman, Lin Guey, Robert Hofmeister, Kyle Trudeau

Nat Rev Drug Discov· September 2025

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Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity.
Essam A Assali, Dovi Shlomo, Jialiu Zeng, Evan P Taddeo, Kyle M Trudeau

FASEB J· March 2019

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Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.
Anton Petcherski, Kyle M Trudeau, Dane M Wolf, Mayuko Segawa, Jennifer Lee

J Mol Biol· December 2018

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Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.
Kiana Mahdaviani, Ilan Y Benador, Shi Su, Raffi A Gharakhanian, Linsey Stiles, Kyle M Trudeau

EMBO Rep· July 2017

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Modulation of mTOR signaling as a strategy for the treatment of Pompe disease.
Jeong-A Lim, Lishu Li, Orian S Shirihai, Kyle M Trudeau, Rosa Puertollano

EMBO Mol Med· March 2017

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Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity.
Kyle M Trudeau, Aaron H Colby, Jialiu Zeng, Guy Las, Jiazuo H Feng

J Cell Biol· July 2016

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Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics.
Maria Fernanda Forni, Julia Peloggia, Kyle Trudeau, Orian Shirihai, Alicia J Kowaltowski

Stem Cells· March 2016

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Measurement of mitochondrial turnover and life cycle using MitoTimer.
Kyle M Trudeau, Roberta A Gottlieb, Orian S Shirihai

Methods Enzymol· August 2015

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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.
Jian Guan, Shikha Mishra, Yiling Qiu, Jianru Shi, Kyle Trudeau

EMBO Mol Med· May 2015

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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.
Jian Guan, Shikha Mishra, Yiling Qiu, Jianru Shi, Kyle Trudeau

EMBO Mol Med· November 2014

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Mitochondrial dysfunction and endoplasmic reticulum stress in diabetic retinopathy: mechanistic insights into high glucose-induced retinal cell death.
Sayon Roy, Kyle Trudeau, Sumon Roy, Thomas Tien, Kevin F Barrette

Curr Clin Pharmacol· November 2013

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MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age.
Andrew W Ferree, Kyle Trudeau, Eden Zik, Ilan Y Benador, Gilad Twig

Autophagy· November 2013

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Downregulation of mitochondrial connexin 43 by high glucose triggers mitochondrial shape change and cytochrome C release in retinal endothelial cells.
Kyle Trudeau, Tetsuya Muto, Sayon Roy

Invest Ophthalmol Vis Sci· September 2012

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A faster, high resolution, mtPA-GFP-based mitochondrial fusion assay acquiring kinetic data of multiple cells in parallel using confocal microscopy.
Alenka Lovy, Anthony J A Molina, Fernanda M Cerqueira, Kyle Trudeau, Orian S Shirihai

J Vis Exp· July 2012

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High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes.
Kyle Trudeau, Anthony J A Molina, Sayon Roy

Invest Ophthalmol Vis Sci· November 2011

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Fenofibric acid reduces fibronectin and collagen type IV overexpression in human retinal pigment epithelial cells grown in conditions mimicking the diabetic milieu: functional implications in retinal permeability.
Kyle Trudeau, Sumon Roy, Wen Guo, Cristina Hernández, Marta Villarroel

Invest Ophthalmol Vis Sci· August 2011

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High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: implications for diabetic retinopathy.
Argyrios Chronopoulos, Kyle Trudeau, Sumon Roy, Hu Huang, Stanley A Vinores

Curr Eye Res· August 2011

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Vascular basement membrane thickening in diabetic retinopathy.
Sayon Roy, John Ha, Kyle Trudeau, Ekaterina Beglova

Curr Eye Res· December 2010

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Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice.
Michael W Bobbie, Sumon Roy, Kyle Trudeau, Stephanie J Munger, Alexander M Simon

Invest Ophthalmol Vis Sci· July 2010

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High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy.
Kyle Trudeau, Anthony J A Molina, Wen Guo, Sayon Roy

Am J Pathol· July 2010

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