Publications by authors named "Adrian Bot"

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Accelerating progress in immune cell therapy for solid tumours.
Adrian Bot, Mark Dudley, Daniel Shelley, Panagiota A Sotiropoulou

Nat Rev Drug Discov· November 2025

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In vivo chimeric antigen receptor (CAR)-T cell therapy.
Adrian Bot, Andrew Scharenberg, Kevin Friedman, Lin Guey, Robert Hofmeister

Nat Rev Drug Discov· September 2025

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In vivo CAR T cell generation to treat cancer and autoimmune disease.
Theresa L Hunter, Yanjie Bao, Yan Zhang, Daiki Matsuda, Romina Riener, Adrian I Bot

Science· June 2025

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Gene and Protein Expression of MAGE and Associated Immune Landscape Elements in Non-Small-Cell Lung Carcinoma and Urothelial Carcinomas.
Izak Faiena, Sabina Adhikary, Colleen Schweitzer, Stephanie H Astrow, Tristan Grogan, Adrian Bot

J Immunother· October 2024

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Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling.
Ali Rezvan, Gabrielle Romain, Mohsen Fathi, Darren Heeke, Melisa Martinez-Paniagua, Adrian Bot

Nat Cancer· July 2024

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Author Correction: Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling.
Ali Rezvan, Gabrielle Romain, Mohsen Fathi, Darren Heeke, Melisa Martinez-Paniagua, Adrian Bot

Nat Cancer· June 2024

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IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.
Caitlin M Tilsed, Barzan A Sadiq, Tyler E Papp, Phurin Areesawangkit, Kenji Kimura, Adrian Bot

Proc Natl Acad Sci U S A· March 2024

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Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma.
Frederick L Locke, Simone Filosto, Justin Chou, Saran Vardhanabhuti, Regis Perbost, Adrian Bot

Nat Med· February 2024

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Liquid biopsy approach to monitor the efficacy and response to CAR-T cell therapy.
Stephanie N Shishido, Olivia Hart, Sujin Jeong, Aidan Moriarty, Darren Heeke, Adrian Bot

J Immunother Cancer· February 2024

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Product Attributes of CAR T-cell Therapy Differentially Associate with Efficacy and Toxicity in Second-line Large B-cell Lymphoma (ZUMA-7).
Simone Filosto, Saran Vardhanabhuti, Miguel A Canales, Xavier Poiré, Lazaros J Lekakis, Adrian Bot

Blood Cancer Discov· January 2024

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Five-year follow-up of ZUMA-1 supports the curative potential of axicabtagene ciloleucel in refractory large B-cell lymphoma.
Sattva S Neelapu, Caron A Jacobson, Armin Ghobadi, David B Miklos, Lazaros J Lekakis, Adrian A Bot

Blood· May 2023

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Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies.
Armin Ghobadi, Jack H Landmann, Alun Carter, Matthew L Cooper, Mehmet Emrah Selli, Adrian Bot

Blood Adv· October 2022

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Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses.
Gabrielle Romain, Paolo Strati, Ali Rezvan, Mohsen Fathi, Irfan N Bandey, Adrian Bot

J Clin Invest· September 2022

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Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma.
Nathalie Scholler, Regis Perbost, Frederick L Locke, Michael D Jain, Sarah Turcan, Adrian Bot

Nat Med· September 2022

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Earlier corticosteroid use for adverse event management in patients receiving axicabtagene ciloleucel for large B-cell lymphoma.
Max S Topp, Tom van Meerten, Roch Houot, Monique C Minnema, Krimo Bouabdallah, Adrian Bot

Br J Haematol· November 2021

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A Phase I, Open-label, Dose-escalation, and Cohort Expansion Study to Evaluate the Safety and Immune Response to Autologous Dendritic Cells Transduced With AdGMCA9 (DC-AdGMCAIX) in Patients With Metastatic Renal Cell Carcinoma.
Izak Faiena, Begoña Comin-Anduix, Beata Berent-Maoz, Adrian Bot, Nazy Zomorodian

J Immunother· September 2021

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CD19 target evasion as a mechanism of relapse in large B-cell lymphoma treated with axicabtagene ciloleucel.
Vicki Plaks, John M Rossi, Justin Chou, Linghua Wang, Soumya Poddar, Adrian Bot

Blood· September 2021

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KTE-X19 anti-CD19 CAR T-cell therapy in adult relapsed/refractory acute lymphoblastic leukemia: ZUMA-3 phase 1 results.
Bijal D Shah, Michael R Bishop, Olalekan O Oluwole, Aaron C Logan, Maria R Baer, Adrian Bot

Blood· July 2021

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A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy.
Ranjan Upadhyay, Jonathan A Boiarsky, Gvantsa Pantsulaia, Judit Svensson-Arvelund, Matthew J Lin, Adrian Bot

Cancer Discov· March 2021

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TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers.
Nisha B Nagarsheth, Scott M Norberg, Andrew L Sinkoe, Sabina Adhikary, Thomas J Meyer, Adrian Bot

Nat Med· March 2021

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Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma.
Frederick L Locke, John M Rossi, Sattva S Neelapu, Caron A Jacobson, David B Miklos, Adrian Bot

Blood Adv· October 2020

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Advanced Cell Mapping Visualizations for Single Cell Functional Proteomics Enabling Patient Stratification.
Nick Bowman, Dong Liu, Patrick Paczkowski, Jon Chen, John Rossi, Adrian Bot

Proteomics· July 2020

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Activation of CAR and non-CAR T cells within the tumor microenvironment following CAR T cell therapy.
Pei-Hsuan Chen, Mikel Lipschitz, Jason L Weirather, Caron Jacobson, Philippe Armand, Adrian Bot

JCI Insight· June 2020

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Author Correction: Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma.
Jennifer N Brudno, Norris Lam, Danielle Vanasse, Yueh-Wei Shen, Jeremy J Rose, Adrian Bot

Nat Med· May 2020

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Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma.
Jennifer N Brudno, Norris Lam, Danielle Vanasse, Yueh-Wei Shen, Jeremy J Rose, Adrian Bot

Nat Med· February 2020

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