Publications by authors named "Laura Maccari"

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Targeting DDX3X Helicase Activity with BA103 Shows Promising Therapeutic Effects in Preclinical Glioblastoma Models.
Annalaura Brai, Valentina Riva, Letizia Clementi, Lucia Falsitta, Claudio Zamperini, Laura Maccari

Cancers (Basel)· November 2021

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SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines.
Filippo Torrisi, Luigi Minafra, Francesco P Cammarata, Gaetano Savoca, Marco Calvaruso, Laura Maccari

Int J Mol Sci· May 2020

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In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
Francesco Orofino, Giuseppina I Truglio, Diego Fiorucci, Ilaria D'Agostino, Matteo Borgini, Laura Maccari

Int J Antimicrob Agents· March 2020

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Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line.
Francesco P Cammarata, Filippo Torrisi, Giusi I Forte, Luigi Minafra, Valentina Bravatà, Laura Maccari

Int J Mol Sci· September 2019

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A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-]Pyrimidine Dual Src/P-Glycoprotein Inhibitor.
Anna Lucia Fallacara, Claudio Zamperini, Ana Podolski-Renić, Jelena Dinić, Tijana Stanković, Laura Maccari

Cancers (Basel)· June 2019

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DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Annalaura Brai, Francesco Martelli, Valentina Riva, Anna Garbelli, Roberta Fazi, Laura Maccari

J Med Chem· March 2019

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Identification of novel nt-MGAM inhibitors for potential treatment of type 2 diabetes: Virtual screening, atom based 3D-QSAR model, docking analysis and ADME study.
Aicha Laoud, Fouad Ferkous, Laura Maccari, Giorgio Maccari, Youcef Saihi

Comput Biol Chem· February 2018

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Novel Hits in the Correction of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis.
Elisabetta Pesci, Laura Bettinetti, Paola Fanti, Luis J V Galietta, Salvatore La Rosa, Laura Maccari

J Med Chem· December 2015

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The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.
Elisa Oppici, Riccardo Montioli, Mirco Dindo, Laura Maccari, Valentina Porcari

ACS Chem Biol· October 2015

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A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.
Madhuri Kalathur, Alberto Toso, Jingjing Chen, Ajinkya Revandkar, Claudia Danzer-Baltzer, Laura Maccari

Nat Commun· June 2015

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Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor.
Arianna Nencini, Cristiana Castaldo, Thomas A Comery, John Dunlop, Eva Genesio, Laura Maccari

Eur J Med Chem· May 2014

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N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
Riccardo Zanaletti, Laura Bettinetti, Cristiana Castaldo, Ilaria Ceccarelli, Giuseppe Cocconcelli, Laura Maccari

J Med Chem· November 2012

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A homogeneous HTRF assay for the identification of inhibitors of the TWEAK-Fn14 protein interaction.
Tiziana Benicchi, Sara Iozzi, Andreas Svahn, Hanna Axelsson, Elisa Mori, Laura Maccari

J Biomol Screen· August 2012

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Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
Riccardo Zanaletti, Laura Bettinetti, Cristiana Castaldo, Giuseppe Cocconcelli, Thomas Comery, Laura Maccari

J Med Chem· May 2012

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Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).
Chiara Ghiron, Simon N Haydar, Suzan Aschmies, Hendrick Bothmann, Cristiana Castaldo, Laura Maccari

J Med Chem· June 2010

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Straightforward recursive partitioning model for discarding insoluble compounds in the drug discovery process.
Claudia Lamanna, Marta Bellini, Alessandro Padova, Goran Westerberg, Laura Maccari

J Med Chem· May 2008

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A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward alpha1 adrenoceptors.
Laura Maccari, Matteo Magnani, Giovannella Strappaghetti, Federico Corelli, Maurizio Botta

J Chem Inf Model· June 2006

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Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine.
Oriol Pineda, Jaume Farràs, Laura Maccari, Fabrizio Manetti, Maurizio Botta

Bioorg Med Chem Lett· October 2004

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3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones.
Fabrizio Manetti, Laura Maccari, Federico Corelli, Maurizio Botta

Curr Top Med Chem· August 2004

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3D QSAR studies for the beta-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): a pseudoreceptor model for taxanes based on the experimental structure of tubulin.
Laura Maccari, Fabrizio Manetti, Federico Corelli, Maurizio Botta

Farmaco· September 2003

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Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.
Laura Betti, Federico Corelli, Monia Floridi, Gino Giannaccini, Laura Maccari

J Med Chem· July 2003

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3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones.
Fabrizio Manetti, Stefano Forli, Laura Maccari, Federico Corelli, Maurizio Botta

Farmaco· May 2003

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Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.
Laura Betti, Maurizio Botta, Federico Corelli, Monia Floridi, Gino Giannaccini, Laura Maccari

J Med Chem· August 2002

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Synthesis and biological activity of new 1,4-benzodioxan-arylpiperazine derivatives. Further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists.
Roberta Barbaro, Laura Betti, Maurizio Botta, Federico Corelli, Gino Giannaccini, Laura Maccari

Bioorg Med Chem· February 2002

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