Publications by authors named "Laura Signor"

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Luminescence Thermometry Beyond the Biological Realm.
Benjamin Harrington, Ziyang Ye, Laura Signor, Andrea D Pickel

ACS Nanosci Au· February 2024

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Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead.
Guanglin Luo, Xiang-Jun Jiang, Ling Chen, Charles M Conway, Michael Gulianello, Laura J Signor

Bioorg Med Chem Lett· July 2021

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Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.
Stephen E Mercer, Prasad V Chaturvedula, Charles M Conway, Deborah A Cook, Carl D Davis, Laura J Signor

Bioorg Med Chem Lett· January 2021

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Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
Michael R Weed, Joseph Polino, Laura Signor, Mark Bookbinder, Deborah Keavy

PLoS One· January 2018

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Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
Prasad V Chaturvedula, Stephen E Mercer, Sokhom S Pin, George Thalody, Cen Xu, Laura Signor

Bioorg Med Chem Lett· June 2013

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Xiaojun Han, Rita L Civiello, Charles M Conway, Deborah A Cook, Carl D Davis, Laura J Signor

Bioorg Med Chem Lett· March 2013

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Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.
Guanglin Luo, Ling Chen, Charles M Conway, Rex Denton, Deborah Keavy, Laura Signor

J Med Chem· December 2012

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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1.
Xiaojun Han, Rita L Civiello, Charles M Conway, Deborah A Cook, Carl D Davis, Laura J Signor

Bioorg Med Chem Lett· July 2012

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Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.
Guanglin Luo, Ling Chen, Charles M Conway, Rex Denton, Deborah Keavy, Laura Signor

ACS Med Chem Lett· April 2012

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Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.
Andrew P Degnan, Prasad V Chaturvedula, Charles M Conway, Deborah A Cook, Carl D Davis, Laura J Signor

J Med Chem· August 2008

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Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception.
Digavalli V Sivarao, Kimberly Newberry, Shaun Langdon, Alicia V Lee, Piyasena Hewawasam, Laura Signor

J Pharmacol Exp Ther· May 2005

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BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.
Svetlana Tertyshnikova, Ronald J Knox, Mary Jane Plym, George Thalody, Corinne Griffin, Laura Signor

J Pharmacol Exp Ther· April 2005

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1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat.
Robert A Myers, Mary Jane Plym, Laura J Signor, Nicholas J Lodge

Neurourol Urodyn· December 2004

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