Publications by authors named "Laura Zonzini"

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1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists.
Fabrizio Micheli, Alessia Bacchi, Simone Braggio, Laura Castelletti, Palmina Cavallini, Laura Zonzini

J Med Chem· September 2016

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1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists.
Fabrizio Micheli, Andrea Bernardelli, Federica Bianchi, Simone Braggio, Laura Castelletti, Laura Zonzini

Bioorg Med Chem· April 2016

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Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.
Fabrizio Micheli, Susanna Cremonesi, Teresa Semeraro, Luca Tarsi, Silvia Tomelleri, Laura Zonzini

Bioorg Med Chem Lett· February 2016

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The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration.
Vivian J A Costantini, Mauro Corsi, Georg Dünstl, Letizia Bettelini, Laura Zonzini

Exp Dermatol· April 2015

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In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE).
Elisabetta Perdona', Vivian J A Costantini, Michela Tessari, Prisca Martinelli, Corrado Carignani, Laura Zonzini

Neuropharmacology· February 2012

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Azabicyclo[3.1.0]hexane-1-carbohydrazides as potent and selective GHSR1a ligands presenting a specific in vivo behavior.
Fabio Maria Sabbatini, Sergio Melotto, Giovanni Bernasconi, Steve M Bromidge, Lucilla D'Adamo, Laura Zonzini

ChemMedChem· November 2011

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1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.
Fabrizio Micheli, Paolo Cavanni, Michela Bettati, Giorgio Bonanomi, Romano Di Fabio, Laura Zonzini

Bioorg Med Chem· June 2011

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Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.
Romano Di Fabio, Giuseppe Alvaro, Cristiana Griffante, Domenica A Pizzi, Daniele Donati, Laura Zonzini

J Med Chem· February 2011

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Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists.
Domenica Antonia Pizzi, Colin Philip Leslie, Angelica Mazzali, Catia Seri, Matteo Biagetti, Laura Zonzini

Bioorg Med Chem Lett· December 2010

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5-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3.
Steven M Bromidge, Roberto Arban, Barbara Bertani, Manuela Borriello, Anna-Maria Capelli, Laura Zonzini

Bioorg Med Chem Lett· December 2010

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Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist.
Colin P Leslie, Matteo Biagetti, Silvia Bison, Steven M Bromidge, Romano Di Fabio, Laura Zonzini

J Med Chem· December 2010

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Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: a new class of Neuropeptide S antagonists.
Fabrizio Micheli, Romano Di Fabio, Angelo Giacometti, Adelheid Roth, Elisa Moro, Laura Zonzini

Bioorg Med Chem Lett· December 2010

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In vivo rat PK profiling in drug discovery: new challenges.
Laura Zonzini, Federica Bianchi, Nicola Cesari, Matteo Sartori

Expert Opin Drug Discov· November 2010

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Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists.
Colin P Leslie, Jonathan Bentley, Matteo Biagetti, Stefania Contini, Romano Di Fabio, Laura Zonzini

Bioorg Med Chem Lett· October 2010

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Design and synthesis of novel tricyclic benzoxazines as potent 5-HT(1A/B/D) receptor antagonists leading to the discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045).
Steven M Bromidge, Roberto Arban, Barbara Bertani, Silvia Bison, Manuela Borriello, Laura Zonzini

J Med Chem· August 2010

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Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists.
Matteo Biagetti, Colin Philip Leslie, Angelica Mazzali, Catia Seri, Domenica Antonia Pizzi, Laura Zonzini

Bioorg Med Chem Lett· August 2010

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6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
Fabrizio Micheli, Paolo Cavanni, Daniele Andreotti, Roberto Arban, Roberto Benedetti, Laura Zonzini

J Med Chem· July 2010

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Oxa-azaspiro derivatives: a novel class of triple re-uptake inhibitors.
Michela Bettati, Paolo Cavanni, Romano Di Fabio, Beatrice Oliosi, Ornella Perini, Laura Zonzini

ChemMedChem· March 2010

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1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.
Fabrizio Micheli, Paolo Cavanni, Roberto Arban, Roberto Benedetti, Barbara Bertani, Laura Zonzini

J Med Chem· March 2010

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Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists.
Fabio M Sabbatini, Romano Di Fabio, Cristiana Griffante, Giorgio Pentassuglia, Laura Zonzini

Bioorg Med Chem Lett· January 2010

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Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
Romano Di Fabio, Cristiana Griffante, Giuseppe Alvaro, Giorgio Pentassuglia, Domenica A Pizzi, Laura Zonzini

J Med Chem· May 2009

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8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.
Steven M Bromidge, Barbara Bertani, Manuela Borriello, Andrea Bozzoli, Stefania Faedo, Laura Zonzini

Bioorg Med Chem Lett· April 2009

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6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.
Steven M Bromidge, Barbara Bertani, Manuela Borriello, Stefania Faedo, Laurie J Gordon, Laura Zonzini

Bioorg Med Chem Lett· October 2008

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Evaluation of the role of intestinal and liver metabolism in the conversion of two different ester prodrugs of sanfetrinem to the parent drug in vitro and in vivo using different rat tissues and a surgically prepared rat model.
Simone Braggio, Alessia Ferrara, Matteo Sartori, Marco Bottacini, Ugo Zanelli, Laura Zonzini

Eur J Pharm Sci· July 2002

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