Publications by authors named "Laval Chan"

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Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.
John J Court, Carl Poisson, Andrzej Ardzinski, Darius Bilimoria, Laval Chan, Kishan Chandupatla

J Med Chem· July 2016

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Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.
James A Henderson, Darius Bilimoria, Monica Bubenik, Caroline Cadilhac, Kevin M Cottrell, Laval C Chan

Bioorg Med Chem Lett· February 2015

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Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.
James A Henderson, Darius Bilimoria, Monica Bubenik, Caroline Cadilhac, Kevin M Cottrell, Laval C Chan

Bioorg Med Chem Lett· February 2015

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers.
Simon Giroux, Darius Bilimoria, Caroline Cadilhac, Kevin M Cottrell, Francois Denis, Laval C Chan

Bioorg Med Chem Lett· February 2015

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.
Simon Giroux, Darius Bilimoria, Caroline Cadilhac, Kevin M Cottrell, Francois Denis, Laval C Chan

Bioorg Med Chem Lett· February 2015

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Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors.
Simon Giroux, Jinwang Xu, T Jagadeeswar Reddy, Mark Morris, Kevin M Cottrell, Laval Chan

ACS Med Chem Lett· March 2014

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Docking ligands into flexible and solvated macromolecules. 2. Development and application of fitted 1.5 to the virtual screening of potential HCV polymerase inhibitors.
Christopher R Corbeil, Pablo Englebienne, Constantin G Yannopoulos, Laval Chan, Sanjoy K Das

J Chem Inf Model· April 2008

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Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Bichitra K Biswal, Meitian Wang, Maia M Cherney, Laval Chan, Constantin G Yannopoulos

J Mol Biol· August 2006

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
Bichitra K Biswal, Maia M Cherney, Meitian Wang, Laval Chan, Constantin G Yannopoulos

J Biol Chem· May 2005

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Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.
Guy Falardeau, Hugo Lachance, Annie St-Pierre, Constantin G Yannopoulos, Marc Drouin, Laval Chan

Bioorg Med Chem Lett· March 2005

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HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY.
Constantin G Yannopoulos, Ping Xu, Feng Ni, Laval Chan, Oswy Z Pereira

Bioorg Med Chem Lett· November 2004

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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.
Laval Chan, Sanjoy K Das, T Jagadeeswar Reddy, Carl Poisson, Mélanie Proulx

Bioorg Med Chem Lett· February 2004

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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.
Laval Chan, Oswy Pereira, T Jagadeeswar Reddy, Sanjoy K Das, Carl Poisson

Bioorg Med Chem Lett· February 2004

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Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.
T Jagadeeswar Reddy, Laval Chan, Nathalie Turcotte, Melanie Proulx, Oswy Z Pereira

Bioorg Med Chem Lett· October 2003

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Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.
Laval Chan, T Jagadeeswar Reddy, Mélanie Proulx, Sanjoy K Das, Oswy Pereira

J Med Chem· April 2003

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
Meitian Wang, Kenneth K-S Ng, Maia M Cherney, Laval Chan, Constantin G Yannopoulos

J Biol Chem· March 2003

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Thiophene-based vitronectin receptor antagonists.
Monica Bubenik, Karen Meerovitch, Frédéric Bergeron, Giorgio Attardo, Laval Chan

Bioorg Med Chem Lett· February 2003

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A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen.
Karen Meerovitch, Frédéric Bergeron, Lorraine Leblond, Brigitte Grouix, Cathy Poirier, Laval Chan

Vascul Pharmacol· February 2003

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Novel nucleotide phosphonate analogues with potent antitumor activity.
Monica Bubenik, Rabindra Rej, Nghe Nguyen-Ba, Giorgio Attardo, France Ouellet, Laval Chan

Bioorg Med Chem Lett· November 2002

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