Publications by authors named "Len Stephens"

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Phosphoinositide acyl chain diversity: comparative analysis across species and mouse tissues.
David Barneda, Vishnu Janardan, John Swales, Maria Ciaccia, Richard Goodwin, Len Stephens

Biochim Biophys Acta Mol Cell Biol Lipids· August 2025

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FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism.
Qian Wang, Chenqi Tao, Yihua Wu, Karen E Anderson, Neoklis Makrides, Len Stephens

Cell Rep· August 2025

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The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.
Pui Ying Chan, Diana Alexander, Ishan Mehta, Larissa Satiko Alcantara Sekimoto Matsuyama, Victoria Harle, Len Stephens

Nat Genet· July 2025

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Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling.
Marion Régnier, Arnaud Polizzi, Tiffany Fougeray, Anne Fougerat, Prunelle Perrier, Len Stephens

PLoS Biol· April 2025

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CDS2 expression regulates de novo phosphatidic acid synthesis.
Daniel M Collins, Vishnu Janardan, David Barneda, Karen E Anderson, Izabella Niewczas, Len R Stephens

Biochem J· October 2024

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The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling.
Victoria Chan, Cristina Camardi, Kai Zhang, Laura A Orofiamma, Karen E Anderson, Len R Stephens

Mol Biol Cell· September 2024

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Phospholipase Cγ regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism.
Qian Wang, Chenqi Tao, Yihua Wu, Karen E Anderson, Abdul Hannan, Len Stephens

bioRxiv· July 2024

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.
Tamara A M Chessa, Piotr Jung, Arqum Anwar, Sabine Suire, Karen E Anderson, Len R Stephens

Mol Cell· August 2023

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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Grace Q Gong, Benoit Bilanges, Ben Allsop, Glenn R Masson, Victoria Roberton, Len R Stephens

Nature· June 2023

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Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
Xu Han, Yang Mei, Rama K Mishra, Honghao Bi, Atul D Jain, Len Stephens

J Clin Invest· March 2023

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Acyl chain selection couples the consumption and synthesis of phosphoinositides.
David Barneda, Vishnu Janardan, Izabella Niewczas, Daniel M Collins, Sabina Cosulich, Len R Stephens

EMBO J· September 2022

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The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling.
Alaa Droubi, Connor Wallis, Karen E Anderson, Saifur Rahman, Aloka de Sa, Len R Stephens

J Cell Biol· September 2022

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ARFs get the BioID treatment: what have we been missing?
David Barneda, Len Stephens, Phillip Hawkins

EMBO J· September 2022

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Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase.
Glenn F W Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E Anderson, Len R Stephens

Nat Cell Biol· May 2022

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PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Len R Stephens

Front Immunol· September 2021

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Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
Natalie K Rynkiewicz, Karen E Anderson, Sabine Suire, Daniel M Collins, Eleftherios Karanasios, Len R Stephens

Sci Signal· November 2020

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Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.
Sabine Suire, Fernando C Baltanas, Anne Segonds-Pichon, Keith Davidson, Eugenio Santos, Len R Stephens

J Leukoc Biol· October 2019

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How is the acyl chain composition of phosphoinositides created and does it matter?
David Barneda, Sabina Cosulich, Len Stephens, Phillip Hawkins

Biochem Soc Trans· October 2019

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Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation.
Abdulrahman Mujalli, Gaëtan Chicanne, Justine Bertrand-Michel, Fanny Viars, Len Stephens

Biochim Biophys Acta Mol Cell Biol Lipids· September 2018

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Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.
Hashem Koohy, Daniel J Bolland, Louise S Matheson, Stefan Schoenfelder, Claudia Stellato, Len Stephens

Genome Biol· September 2018

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Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
David Gyori, Ee Lyn Lim, Francis M Grant, Dominik Spensberger, Rahul Roychoudhuri, Len R Stephens

JCI Insight· June 2018

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PTEN Regulates PI(3,4)P Signaling Downstream of Class I PI3K.
Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Len R Stephens

Mol Cell· November 2017

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In-depth PtdIns(3,4,5)P signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.
Tom N Durrant, James L Hutchinson, Kate J Heesom, Karen E Anderson, Len R Stephens

Blood Adv· June 2017

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Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.
David Gyori, Tamara Chessa, Phillip T Hawkins, Len R Stephens

Cancers (Basel)· March 2017

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cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.
Ondrej Cerny, Karen E Anderson, Len R Stephens, Phillip T Hawkins, Peter Sebo

J Immunol· February 2017

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