Publications by authors named "Lesley McLaughlin"

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Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy.
A Kenneth MacLeod, De Lin, Jeffrey T-J Huang, Lesley A McLaughlin, Colin J Henderson

Clin Cancer Res· May 2018

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Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants.
A Kenneth MacLeod, Lesley A McLaughlin, Colin J Henderson, C Roland Wolf

Drug Metab Dispos· January 2017

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The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function.
Emily E Scott, C Roland Wolf, Michal Otyepka, Sara C Humphreys, James R Reed, Lesley A McLaughlin

Drug Metab Dispos· April 2016

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HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents.
Michael McMahon, Kathryn H Campbell, A Kenneth MacLeod, Lesley A McLaughlin, Colin J Henderson

PLoS One· December 2015

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Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.
Nico Scheer, Yury Kapelyukh, Anja Rode, Stefan Oswald, Diana Busch, Lesley A McLaughlin

Drug Metab Dispos· November 2015

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Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.
A Kenneth MacLeod, Lesley A McLaughlin, Colin J Henderson, C Roland Wolf

Cancer Res· November 2015

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Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
Rumen V Kostov, Elena V Knatko, Lesley A McLaughlin, Colin J Henderson, Suqing Zheng

Biochem Biophys Res Commun· September 2015

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Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.
Colin J Henderson, Lesley A McLaughlin, Nico Scheer, Lesley A Stanley, C Roland Wolf

Mol Pharmacol· April 2015

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Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.
Colin J Henderson, Lesley A McLaughlin, Maria Osuna-Cabello, Malcolm Taylor, Ian Gilbert

Biochem J· February 2015

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Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism.
Nico Scheer, Lesley A McLaughlin, Anja Rode, A Kenneth Macleod, Colin J Henderson

Drug Metab Dispos· June 2014

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A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice.
Colin J Henderson, Lesley A McLaughlin, Robert D Finn, Sebastien Ronseaux, Yury Kapelyukh

Drug Metab Dispos· January 2014

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Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.
Colin J Henderson, Lesley A McLaughlin, C Roland Wolf

Mol Pharmacol· June 2013

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NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
David S Riddick, Xinxin Ding, C Roland Wolf, Todd D Porter, Amit V Pandey, Lesley A McLaughlin

Drug Metab Dispos· January 2013

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Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits.
Lu-Yun Lian, Philip Widdowson, Lesley A McLaughlin, Mark J I Paine

PLoS One· October 2011

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Cytochrome b5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis.
Robert D Finn, Lesley A McLaughlin, Catherine Hughes, Chengli Song, Colin J Henderson

Transgenic Res· June 2011

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Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism.
Lesley A McLaughlin, Sebastien Ronseaux, Robert D Finn, Colin J Henderson, C Roland Wolf

Mol Pharmacol· August 2010

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Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.
Robert D Finn, Lesley A McLaughlin, Sebastien Ronseaux, Ian Rosewell, J Brian Houston

J Biol Chem· November 2008

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Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.
Lesley A McLaughlin, Leslie J Dickmann, C Roland Wolf, Colin J Henderson

Drug Metab Dispos· July 2008

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Establishment of functional human cytochrome P450 monooxygenase systems in Escherichia coli.
Michael P Pritchard, Lesley McLaughlin, Thomas Friedberg

Methods Mol Biol· June 2006

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Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
Lesley A McLaughlin, Mark J I Paine, Carol A Kemp, Jean-Didier Maréchal, Jack U Flanagan

J Biol Chem· November 2005

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Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
Jack U Flanagan, Jean-Didier Maréchal, Richard Ward, Carol A Kemp, Lesley A McLaughlin

Biochem J· June 2004

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Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.
Jack U Flanagan, Lesley A McLaughlin, Mark J I Paine, Michael J Sutcliffe, Gordon C K Roberts

Biochem J· March 2003

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Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.
Mark J I Paine, Lesley A McLaughlin, Jack U Flanagan, Carol A Kemp, Michael J Sutcliffe

J Biol Chem· February 2003

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