Publications by authors named "Line Oste"

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Discovery of GLPG4471, a potent and selective IRAK4 inhibitor for the treatment of inflammatory and autoimmune diseases.
Oscar Mammoliti, Florence Bonnaterre, Gregory Newsome, Rhalid Akkari, Miriam López-Ramos, Line Oste

Bioorg Med Chem Lett· December 2025

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Structure-Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor.
Hans Kelgtermans, Maxim De Wachter, Stijn Heyndrickx, Sandy El Bkassiny, Tatiana Lacarriere, Line Oste

J Med Chem· August 2025

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Design of a potent and selective dual JAK1/TYK2 inhibitor.
Oscar Mammoliti, Christel Menet, Céline Cottereaux, Javier Blanc, Ann De Blieck, Line Oste

Bioorg Med Chem· November 2024

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Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases.
Oscar Mammoliti, Sébastien Martina, Pieter Claes, Ghjuvanni Coti, Roland Blanque, Line Oste

J Med Chem· June 2024

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IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.
Stéphanie Lavazais, Manja Jargosch, Sonia Dupont, Frédéric Labéguère, Christel Menet, Line Oste

Sci Transl Med· February 2023

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Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.
Oscar Mammoliti, Koen Jansen, Sandy El Bkassiny, Adeline Palisse, Nicolas Triballeau, Line Oste

J Med Chem· October 2021

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Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
Oscar Mammoliti, Adeline Palisse, Caroline Joannesse, Sandy El Bkassiny, Brigitte Allart, Line Oste

J Med Chem· May 2021

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Discovery of 9-Cyclopropylethynyl-2-(()-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
Frédéric Labéguère, Sonia Dupont, Luke Alvey, Florilène Soulas, Gregory Newsome, Line Oste

J Med Chem· November 2020

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Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
Nicolas Desroy, Christopher Housseman, Xavier Bock, Agnès Joncour, Natacha Bienvenu, Line Oste

J Med Chem· May 2017

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Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
Mathieu Pizzonero, Sonia Dupont, Marielle Babel, Stéphane Beaumont, Natacha Bienvenu, Line Oste

J Med Chem· December 2014

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A multiparameter approach to monitor disease activity in collagen-induced arthritis.
Sylvie Seeuws, Peggy Jacques, Jens Van Praet, Michael Drennan, Julie Coudenys, Line Oste

Arthritis Res Ther· January 2011

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Role of dietary phosphorus and degree of uremia in the development of renal bone disease in rats.
Line Oste, Geert J Behets, Geert Dams, An R Bervoets, Rita L Marynissen

Ren Fail· June 2008

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Development and reversibility of impaired mineralization associated with lanthanum carbonate treatment in chronic renal failure rats.
An R J Bervoets, Line Oste, Geert J Behets, Geert Dams, Ronny Blust

Bone· June 2006

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Localization of lanthanum in bone of chronic renal failure rats after oral dosing with lanthanum carbonate.
Geert J Behets, Steven C Verberckmoes, Line Oste, An R Bervoets, Murielle Salomé

Kidney Int· May 2005

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Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats.
Line Oste, An R Bervoets, Geert J Behets, Geert Dams, Rita L Marijnissen

Kidney Int· March 2005

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