Publications by authors named "Linus S Lin"

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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.
Harry R Chobanian, Yan Guo, Ping Liu, Marc D Chioda, Selena Fung, Linda Chang, Mark McLaughlin, Lin-Lin Shiao, Linus S Lin

ACS Med Chem Lett· June 2014

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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.
Ping Liu, Terence G Hamill, Marc Chioda, Harry Chobanian, Selena Fung, Linda Chang, Linus S Lin, Lin-Lin Shiao, Ling Xu

ACS Med Chem Lett· June 2013

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Harry R Chobanian, Yan Guo, Ping Liu, Thomas J Lanza, Marc Chioda, Linda Chang, Linus S Lin

Bioorg Med Chem· May 2012

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Harry R Chobanian, Yan Guo, Ping Liu, Marc Chioda, Thomas J Lanza, Linda Chang, Linus S Lin

ACS Med Chem Lett· March 2012

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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.
Ping Liu, Thomas J Lanza, Marc Chioda, Carrie Jones, Harry R Chobanian, Linda Chang, Linus S Lin

ACS Med Chem Lett· December 2011

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Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists.
Michael M-C Lo, Harry R Chobanian, Oksana Palyha, Yanqing Kan, Theresa M Kelly, Linus S Lin

Bioorg Med Chem Lett· April 2011

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Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist.
Xiao-Ming Guan, Joseph M Metzger, Liming Yang, Kate A Raustad, Sheng-Ping Wang, Linus S Lin

J Pharmacol Exp Ther· February 2011

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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Iyassu K Sebhat, Christopher Franklin, Michael M-C Lo, David Chen, James P Jewell, Linus S Lin

ACS Med Chem Lett· January 2011

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Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments.
Joseph M Metzger, Karen Gagen, Kate A Raustad, Liming Yang, Amanda White, Linus S Lin

Am J Physiol Endocrinol Metab· November 2010

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Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
Ihor E Kopka, Linus S Lin, James P Jewell, Thomas J Lanza, Tung M Fong

Bioorg Med Chem Lett· August 2010

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Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Mark Hadden, Allan Goodman, Cheng Guo, Peter R Guzzo, Alan J Henderson, Linus S Lin

Bioorg Med Chem Lett· May 2010

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Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists.
Cheng Guo, Peter R Guzzo, Mark Hadden, Bruce J Sargent, Larry Yet, Linus S Lin

Bioorg Med Chem Lett· May 2010

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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Jian Liu, Shuwen He, Tianying Jian, Peter H Dobbelaar, Iyassu K Sebhat, Linus S Lin

Bioorg Med Chem Lett· April 2010

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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Shuwen He, Peter H Dobbelaar, Jian Liu, Tianying Jian, Iyassu K Sebhat, Linus S Lin

Bioorg Med Chem Lett· March 2010

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Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Xiao-Ming Guan, Howard Chen, Peter H Dobbelaar, Yan Dong, Tung M Fong, Linus S Lin, Sloan Stribling

Cell Metab· February 2010

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PET imaging studies in rhesus monkey with the cannabinoid-1 (CB1) receptor ligand [11C]CB-119.
Terence G Hamill, Linus S Lin, William Hagmann, Ping Liu, James Jewell

Mol Imaging Biol· October 2009

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Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
Wu Du, James P Jewell, Linus S Lin, Vincent J Colandrea, Jing C Xiao

Bioorg Med Chem Lett· September 2009

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Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.
Linus S Lin, Thomas Lanza, James P Jewell, Ping Liu, Carrie Jones

J Med Chem· June 2009

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Similar in vitro pharmacology of human cannabinoid CB1 receptor variants expressed in CHO cells.
Jing Chen Xiao, James P Jewell, Linus S Lin, William K Hagmann, Tung M Fong

Brain Res· October 2008

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Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
Linus S Lin, Sookhee Ha, Richard G Ball, Nancy N Tsou, Laurie A Castonguay

J Med Chem· April 2008

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Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
Ping Liu, Linus S Lin, Terence G Hamill, James P Jewell, Thomas J Lanza

J Med Chem· July 2007

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Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
Tung M Fong, Xiao-Ming Guan, Donald J Marsh, Chun-Pyn Shen, D Sloan Stribling, Linus S Lin

J Pharmacol Exp Ther· June 2007

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[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor.
H Donald Burns, Koen Van Laere, Sandra Sanabria-Bohórquez, Terence G Hamill, Guy Bormans, Linus S Lin

Proc Natl Acad Sci U S A· June 2007

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Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.
Helen E Armstrong, Amy Galka, Linus S Lin, Thomas J Lanza, James P Jewell, Linda L Chang, D Sloan Stribling

Bioorg Med Chem Lett· April 2007

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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
Linus S Lin, Thomas J Lanza, James P Jewell, Ping Liu, Shrenik K Shah, D Sloan Stribling

J Med Chem· December 2006

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