Publications by authors named "Sookhee Ha"

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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Douglas G Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Sookhee N Ha, David A Thaisrivongs, Petr Vachal, Tian Zhao, Harold B Wood

Circulation· July 2023

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Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
Simon Ng, Alexander C Brueckner, Soheila Bahmanjah, Qiaolin Deng, Jennifer M Johnston, Bahanu Habulihaz, Sookhee Ha

J Med Chem· July 2022

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A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
Thomas J Tucker, Mark W Embrey, Candice Alleyne, Rupesh P Amin, Alan Bass, Bhavana Bhatt, Sookhee N Ha, Mike Hafey, BethAnn Murphy, Aurash Shahripour, Harold B Wood

J Med Chem· November 2021

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, Wonsuk Chang, Rachael Ford, Sookhee Ha, Michael Kavana, Oksana Palyha, Gopal Parthasarathy, Sujata Sharma, Kake Zhao

Cell Chem Biol· February 2021

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Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
Candice Alleyne, Rupesh P Amin, Bhavana Bhatt, Elisabetta Bianchi, J Craig Blain, Sookhee N Ha, Aurash Shahripour

J Med Chem· November 2020

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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Whitney L Petrilli, Gregory C Adam, Roman S Erdmann, Pravien Abeywickrema, Vijayalakshmi Agnani, Wonsuk Chang, Rachael Ford, Sookhee Ha, Michael Kavana, Oksana Palyha, Gopal Parthasarathy, Sujata Sharma, Kake Zhao

Cell Chem Biol· January 2020

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Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles.
Brett A Hopkins, Hyelee Lee, Sookhee Ha, Lisa Nogle, Berengere Sauvagnat, Graham F Smith

ACS Med Chem Lett· June 2019

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Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.
Anthony W Partridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Charles Johannes, Srinivasaraghavan Kannan, Mohan R Pradhan, Chandra S Verma, Sookhee Ha

Molecules· June 2019

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Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Tomi K Sawyer, Anthony W Partridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Shuhui Lim, Charles Johannes, Chandra Verma, Srinivasaraghavan Kannan, Sookhee Ha

Bioorg Med Chem· June 2018

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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
Mihirbaran Mandal, Zheng Tan, Christina Madsen-Duggan, Alexei V Buevich, John P Caldwell, Charles G Garlisi, Charles Gill, Sookhee Nicole Ha, Hao Wang, Haifeng Tang

J Med Chem· May 2017

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Molecular Simulations Identify Binding Poses and Approximate Affinities of Stapled α-Helical Peptides to MDM2 and MDMX.
Joseph A Morrone, Alberto Perez, Qiaolin Deng, Sookhee N Ha, M Katharine Holloway

J Chem Theory Comput· February 2017

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Investigation of piperazine benzamides as human β adrenergic receptor agonists for the treatment of overactive bladder.
Bart H Harper, Liping Wang, Cheng Zhu, Nam F Kar, Bing Li, Sookhee N Ha, Jeffrey J Hale, Richard Berger

Bioorg Med Chem Lett· February 2017

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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Yuping Zhu, Reynalda K de Jesus, Haifeng Tang, Shawn P Walsh, Jinlong Jiang, Aurash Shahripour, Sookhee Ha, Richard M Brochu, Caryn Hampton, Juliann Ehrhart

Bioorg Med Chem Lett· December 2016

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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.
Shu-Wei Yang, Jianping Pan, Christine Yang, Marc Labroli, Weidong Pan, Sookhee Ha, Charles G Garlisi, Hao Wang

Bioorg Med Chem Lett· October 2016

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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.
Sang Ho Lee, Hao Wang, Marc Labroli, Sandra Koseoglu, Paul Zuck, Charles Gill, Sookhee Ha, Charles G Garlisi

Sci Transl Med· March 2016

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Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent.
Sheo B Singh, Priya Dayananth, Carl J Balibar, Charles G Garlisi, Jun Lu, Sookhee Ha

Antimicrob Agents Chemother· February 2016

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Discovery of benzamides as potent human β3 adrenergic receptor agonists.
Cheng Zhu, Nam F Kar, Bing Li, Melissa Costa, Karen H Dingley, Sookhee N Ha, Jeffrey J Hale

Bioorg Med Chem Lett· January 2016

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Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Scott D Edmondson, Cheng Zhu, Nam Fung Kar, Jerry Di Salvo, Hiroshi Nagabukuro, Richard Berger, Bart Harper, Richard Ball, Sookhee Ha

J Med Chem· January 2016

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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Nardos Teumelsan, Jessica Frie, Michael Margulis, Richard Visconti, Richard M Brochu, Caryn Hampton, Kashmira Shah, Michael Forrest, Sookhee Ha

ACS Med Chem Lett· July 2015

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Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.
Timothy A Blizzard, Helen Chen, Seongkon Kim, Jane Wu, Rena Bodner, Young-Whan Park, Nichelle Hairston, Nandini Sharma, Sookhee Ha, Milton L Hammond

Bioorg Med Chem Lett· February 2014

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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.
Haifeng Tang, Shawn P Walsh, Yan Yan, Reynalda K de Jesus, Aurash Shahripour, Sookhee Ha, Richard Brochu

ACS Med Chem Lett· May 2012

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Platensimycin and platencin congeners from Streptomyces platensis.
Chaowei Zhang, John Ondeyka, Kithsiri Herath, Hiranthi Jayasuriya, Ziqiang Guan, Sookhee N Ha

J Nat Prod· March 2011

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Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
Ihor E Kopka, Linus S Lin, James P Jewell, Thomas J Lanza, Tung M Fong, Sookhee Ha, William K Hagmann

Bioorg Med Chem Lett· August 2010

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A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
Yan G Ni, Jon H Condra, Laura Orsatti, Xun Shen, Stefania Di Marco, Richard T Cummings, Anka Ehrhardt, Sookhee Ha, Holly A Hammond, Ayesha Sitlani

J Biol Chem· April 2010

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Isolation, structure and biological activities of platencin A(2)-A(4) from Streptomyces platensis.
Chaowei Zhang, John Ondeyka, Lisa Dietrich, Francis P Gailliot, Michelle Hesse, Michael Lester, Sookhee N Ha

Bioorg Med Chem· April 2010

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