Publications by authors named "Lisa Nogle"

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General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C()-Rich Benzene Bioisosteres.
Xiaoshen Ma, Adam M Beard, Samantha A Burgess, Miroslawa Darlak, Justin A Newman, Lisa M Nogle

J Org Chem· April 2024

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Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
Solomon D Kattar, Anmol Gulati, Kaila A Margrey, Mitchell H Keylor, Michael Ardolino, Lisa Nogle

J Med Chem· November 2023

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
David A Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W Chau, Lisa Nogle

J Med Chem· December 2022

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Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
Mitchell H Keylor, Anmol Gulati, Solomon D Kattar, Rebecca E Johnson, Ryan W Chau, Lisa Nogle

J Med Chem· January 2022

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Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
Derun Li, Hongjun Zhang, Thomas W Lyons, Min Lu, Abdelghani Achab, Lisa Nogle

ACS Med Chem Lett· November 2021

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Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles.
Brett A Hopkins, Hyelee Lee, Sookhee Ha, Lisa Nogle, Berengere Sauvagnat

ACS Med Chem Lett· June 2019

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Evaluation of non-conventional polar modifiers on immobilized chiral stationary phases for improved resolution of enantiomers by supercritical fluid chromatography.
Jimmy O DaSilva, Brandyce Coes, Lisa Frey, Ingrid Mergelsberg, Ray McClain, Lisa Nogle

J Chromatogr A· February 2014

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Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
David J O'Neill, Adedayo Adedoyin, Jenifer A Bray, Darlene C Deecher, Andrew Fensome, Lisa Nogle

J Med Chem· October 2011

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Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists.
Aimee L Crombie, Thomas M Antrilli, Brandon A Campbell, David L Crandall, Amedeo A Failli, Lisa M Nogle

Bioorg Med Chem Lett· June 2010

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Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.
Lori K Gavrin, Paige E Mahaney, Douglas Jenkins, Lisa M Nogle, Cheryl A Mugford

ACS Med Chem Lett· June 2010

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Unexpected rearrangement of enantiomerically pure 3-aminoquinuclidine as a simple way of preparing diastereomeric octahydropyrrolo[2,3-c]pyridine derivatives.
Igor Goljer, Albert Molinari, Yanan He, Lisa Nogle, Weilin Sun

Chirality· July 2009

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Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms.
T Luke Simmons, Lisa M Nogle, Joseph Media, Frederick A Valeriote, Susan L Mooberry

J Nat Prod· June 2009

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Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
William J Moore, Jeffrey C Kern, Ramesh Bhat, Thomas J Commons, Shoichi Fukayama, Lisa Nogle

J Med Chem· January 2009

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Sub-2 microm HPLC coupled with sub-ppm mass accuracy for analysis of pharmaceutical compound libraries.
Justin G Stroh, Christopher J Petucci, Scott J Brecker, Lisa M Nogle

J Sep Sci· December 2008

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Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
Casey C McComas, An T Vu, Paige E Mahaney, Stephen T Cohn, Andrew Fensome, Lisa Nogle

Bioorg Med Chem Lett· September 2008

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Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Baihua Hu, Elaine Quinet, Rayomand Unwalla, Mike Collini, James Jetter, Lisa Nogle

Bioorg Med Chem Lett· January 2008

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Application of chiral technology in a pharmaceutical company. Enantiomeric separation and spectroscopic studies of key asymmetric intermediates using a combination of techniques. Phenylglycidols.
Oliver McConnell, Yanan He, Lisa Nogle, Ani Sarkahian

Chirality· September 2007

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Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery: building chiral technology toolboxes.
Oliver McConnell, Alvin Bach, Carl Balibar, Neal Byrne, Yanxuan Cai, Lisa Nogle

Chirality· September 2007

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Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.
Paige E Mahaney, An T Vu, Casey C McComas, Puwen Zhang, Lisa M Nogle

Bioorg Med Chem· December 2006

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Regioselective synthesis of substituted pyrroles: efficient palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylate derivatives.
Matthew L Crawley, Igor Goljer, Douglas J Jenkins, John F Mehlmann, Lisa Nogle

Org Lett· December 2006

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Preparative separation and identification of derivatized beta-methylphenylalanine enantiomers by chiral SFC, HPLC and NMR for development of new peptide ligand mimetics in drug discovery.
Lisa M Nogle, Charles W Mann, William L Watts, Yingru Zhang

J Pharm Biomed Anal· March 2006

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Integrity profiling of high throughput screening hits using LC-MS and related techniques.
Edward H Kerns, Li Di, Jim Bourassa, Jonathan Gross, Nelson Huang, Lisa Nogle

Comb Chem High Throughput Screen· September 2005

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Rapid method development for chiral separation in drug discovery using multi-column parallel screening and circular dichroism signal pooling.
Yingru Zhang, William Watts, Lisa Nogle, Oliver McConnell

J Chromatogr A· September 2004

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Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.
Daniel J Edwards, Brian L Marquez, Lisa M Nogle, Kerry McPhail, Douglas E Goeger

Chem Biol· June 2004

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Diverse secondary metabolites from a Puerto Rican collection of Lyngbyamajuscula.
Lisa M Nogle, William H Gerwick

J Nat Prod· February 2003

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