Publications by authors named "Caryn Hampton"

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Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
Jinlong Jiang, Fa-Xiang Ding, Xiaoyan Zhou, Thomas J Bateman, Shuzhi Dong, Caryn Hampton

J Med Chem· June 2021

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Early echocardiographic predictors of outcomes in the mouse transverse aortic constriction heart failure model.
Caryn Hampton, Raymond Rosa, Barry Campbell, Richard Kennan, Loise Gichuru

J Pharmacol Toxicol Methods· July 2017

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Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Shuzhi Dong, Kelsey VanGelder, Zhi-Cai Shi, Yang Yu, Zhicai Wu, Caryn Hampton

Bioorg Med Chem Lett· June 2017

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Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model.
Caryn Hampton, Raymond Rosa, Daphne Szeto, Gail Forrest, Barry Campbell

SAGE Open Med· March 2017

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The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.
Harry R Chobanian, Yan Guo, Barbara Pio, Haifeng Tang, Nardos Teumelsan, Caryn Hampton

Bioorg Med Chem Lett· February 2017

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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Yuping Zhu, Reynalda K de Jesus, Haifeng Tang, Shawn P Walsh, Jinlong Jiang, Caryn Hampton

Bioorg Med Chem Lett· December 2016

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The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
Caryn Hampton, Xiaoyan Zhou, Birgit T Priest, Lee-Yuh Pai, John P Felix

J Pharmacol Exp Ther· October 2016

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Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
Haifeng Tang, Yuping Zhu, Nardos Teumelsan, Shawn P Walsh, Aurash Shahripour, Caryn Hampton

ACS Med Chem Lett· July 2016

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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Reynalda K de Jesus, Nardos Teumelsan, Caryn Hampton

Bioorg Med Chem Lett· May 2016

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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Nardos Teumelsan, Jessica Frie, Caryn Hampton

ACS Med Chem Lett· July 2015

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Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Haifeng Tang, Reynald K de Jesus, Shawn P Walsh, Yuping Zhu, Yan Yan, Caryn Hampton

Bioorg Med Chem Lett· November 2013

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