Publications by authors named "Birgit T Priest"

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Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nuria Diaz, Carlos Perez, Ana Maria Escribano, Gema Sanz, Julian Priego, Birgit T Priest

Nature· May 2024

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Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.
Benjamin Wilenkin, Kevin D Burris, Brian J Eastwood, Emanuele Sher, Andrew C Williams, Birgit T Priest

Assay Drug Dev Technol· October 2019

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The therapeutic potential of targeting the K1.1 (renal outer medullary K) channel.
Birgit T Priest, Alexander Pasternak

Future Med Chem· October 2017

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Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Shuzhi Dong, Kelsey VanGelder, Zhi-Cai Shi, Yang Yu, Zhicai Wu, Birgit T Priest

Bioorg Med Chem Lett· June 2017

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Voltage-gated Na currents in human dorsal root ganglion neurons.
Xiulin Zhang, Birgit T Priest, Inna Belfer, Michael S Gold

Elife· May 2017

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Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Yuping Zhu, Reynalda K de Jesus, Haifeng Tang, Shawn P Walsh, Jinlong Jiang, Birgit T Priest

Bioorg Med Chem Lett· December 2016

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.
Liangqin Guo, Dann L Parker, Yi Zang, Ramzi F Sweis, Weiguo Liu, Birgit T Priest

ACS Med Chem Lett· December 2016

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The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
Caryn Hampton, Xiaoyan Zhou, Birgit T Priest, Lee-Yuh Pai, John P Felix

J Pharmacol Exp Ther· October 2016

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Cardiac ion channels.
Birgit T Priest, Jeff S McDermott

Channels (Austin)· September 2016

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Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
Haifeng Tang, Yuping Zhu, Nardos Teumelsan, Shawn P Walsh, Aurash Shahripour, Birgit T Priest

ACS Med Chem Lett· July 2016

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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Reynalda K de Jesus, Nardos Teumelsan, Birgit T Priest

Bioorg Med Chem Lett· May 2016

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Optimization of a High-Throughput Assay for Calcium Channel Modulators on IonWorks Barracuda.
Rok Cerne, Mark Wakulchik, Baolin Li, Kevin D Burris, Birgit T Priest

Assay Drug Dev Technol· March 2016

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IonWorks Barracuda Assay for Assessment of State-Dependent Sodium Channel Modulators.
Rok Cerne, Mark Wakulchik, Michael J Krambis, Kevin D Burris, Birgit T Priest

Assay Drug Dev Technol· March 2016

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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Nardos Teumelsan, Jessica Frie, Birgit T Priest

ACS Med Chem Lett· July 2015

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Phenotypic screening in the 21st century.
Birgit T Priest, Gul Erdemli

Front Pharmacol· December 2014

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Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker.
Zhi-Yong Tan, Birgit T Priest, Jeffrey L Krajewski, Kelly L Knopp, Eric S Nisenbaum

FEBS Lett· November 2014

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Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.
Zhi-Yong Tan, Andrew D Piekarz, Birgit T Priest, Kelly L Knopp, Jeffrey L Krajewski

J Neurosci· May 2014

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Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
Maria L Garcia, Birgit T Priest, Magdalena Alonso-Galicia, Xiaoyan Zhou, John P Felix

J Pharmacol Exp Ther· January 2014

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Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Haifeng Tang, Reynald K de Jesus, Shawn P Walsh, Yuping Zhu, Yan Yan, Birgit T Priest

Bioorg Med Chem Lett· November 2013

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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Scott B Hoyt, Clare London, Catherine Abbadie, John P Felix, Maria L Garcia, Birgit T Priest

Bioorg Med Chem Lett· June 2013

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The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.
John P Felix, Birgit T Priest, Kelli Solly, Timothy Bailey, Richard M Brochu

Assay Drug Dev Technol· October 2012

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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.
Haifeng Tang, Shawn P Walsh, Yan Yan, Reynalda K de Jesus, Aurash Shahripour, Birgit T Priest

ACS Med Chem Lett· May 2012

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Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Sriram Tyagarajan, Prasun K Chakravarty, Bishan Zhou, Brett Taylor, Ronsar Eid, Birgit T Priest

Bioorg Med Chem Lett· December 2010

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Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Sriram Tyagarajan, Prasun K Chakravarty, Bishan Zhou, Michael H Fisher, Mathew J Wyvratt, Birgit T Priest

Bioorg Med Chem Lett· September 2010

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