Publications by authors named "Richard Brochu"

Claim this Profile
D
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Yuping Zhu, Reynalda K de Jesus, Haifeng Tang, Shawn P Walsh, Jinlong Jiang, Richard M Brochu

Bioorg Med Chem Lett· December 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
Haifeng Tang, Yuping Zhu, Nardos Teumelsan, Shawn P Walsh, Aurash Shahripour, Richard M Brochu

ACS Med Chem Lett· July 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Reynalda K de Jesus, Nardos Teumelsan, Richard M Brochu

Bioorg Med Chem Lett· May 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Nardos Teumelsan, Jessica Frie, Richard M Brochu

ACS Med Chem Lett· July 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
Maria L Garcia, Birgit T Priest, Magdalena Alonso-Galicia, Xiaoyan Zhou, John P Felix, Richard M Brochu

J Pharmacol Exp Ther· January 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Haifeng Tang, Reynald K de Jesus, Shawn P Walsh, Yuping Zhu, Yan Yan, Richard M Brochu

Bioorg Med Chem Lett· November 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.
John P Felix, Birgit T Priest, Kelli Solly, Timothy Bailey, Richard M Brochu

Assay Drug Dev Technol· October 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.
Haifeng Tang, Shawn P Walsh, Yan Yan, Reynalda K de Jesus, Aurash Shahripour, Richard Brochu

ACS Med Chem Lett· May 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Sriram Tyagarajan, Prasun K Chakravarty, Bishan Zhou, Brett Taylor, Ronsar Eid, Richard M Brochu

Bioorg Med Chem Lett· December 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Substituted biaryl pyrazoles as sodium channel blockers.
Sriram Tyagarajan, Prasun K Chakravarty, Bishan Zhou, Brett Taylor, Michael H Fisher, Richard M Brochu

Bioorg Med Chem Lett· September 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Sriram Tyagarajan, Prasun K Chakravarty, Bishan Zhou, Michael H Fisher, Mathew J Wyvratt, Richard M Brochu

Bioorg Med Chem Lett· September 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.
Brande S Williams, John P Felix, Birgit T Priest, Richard M Brochu, Kefei Dai

Biochemistry· December 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.
Ivy E Dick, Richard M Brochu, Yamini Purohit, Gregory J Kaczorowski, William J Martin

J Pain· April 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.
Richard M Brochu, Ivy E Dick, Jason W Tarpley, Erin McGowan, David Gunner

Mol Pharmacol· March 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A high-capacity membrane potential FRET-based assay for NaV1.8 channels.
Chou J Liu, Birgit T Priest, Randal M Bugianesi, Paula M Dulski, John P Felix, Richard M Brochu

Assay Drug Dev Technol· February 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells.
James Herrington, Manuel Sanchez, Denize Wunderler, Lizhen Yan, Randal M Bugianesi, Richard M Brochu

J Physiol· August 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
Jun Liang, Richard M Brochu, Charles J Cohen, Ivy E Dick, John P Felix

Bioorg Med Chem Lett· June 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels.
Lizhen Yan, James Herrington, Ethan Goldberg, Paula M Dulski, Randal M Bugianesi, Richard M Brochu

Mol Pharmacol· May 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
Birgit T Priest, Maria L Garcia, Richard E Middleton, Richard M Brochu, Samantha Clark

Biochemistry· August 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.
John P Felix, Brande S Williams, Birgit T Priest, Richard M Brochu, Ivy E Dick

Assay Drug Dev Technol· June 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Two tarantula peptides inhibit activation of multiple sodium channels.
Richard E Middleton, Vivien A Warren, Richard L Kraus, Jeremy C Hwang, Chou J Liu, Richard M Brochu

Biochemistry· December 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis