Publications by authors named "Lu-Lin Jiang"

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Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression.
Michael L van de Weijer, Krishna Samanta, Nikita Sergejevs, LuLin Jiang, Maria Emilia Dueñas

Nat Commun· October 2024

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BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice.
C Y Daniel Lee, Amberlene J De La Rocha, Kellie Inouye, Peter Langfelder, Anthony Daggett, Lu-Lin Jiang

bioRxiv· August 2023

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A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease.
Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li

Sci Transl Med· September 2022

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LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.
Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku

Mol Neurodegener· June 2022

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USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation.
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, LuLin Jiang

J Clin Invest· March 2022

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GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.
Peng Xu, Jerry C Chang, Xiaopu Zhou, Wei Wang, Michael Bamkole, Lu-Lin Jiang

J Exp Med· August 2021

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Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, LuLin Jiang

J Exp Med· December 2020

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Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.
Jessica Stupack, Xiao-Peng Xiong, Lu-Lin Jiang, Tongmei Zhang, Lisa Zhou

J Neurosci· July 2020

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Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.
Lu-Lin Jiang, Bing Zhu, Yingjun Zhao, Xiaoguang Li, Tongfei Liu

J Clin Invest· May 2019

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Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
Zoltan Simandi, Krisztian Pajer, Katalin Karolyi, Tatiana Sieler, Lu-Lin Jiang

J Neurosci· August 2018

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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Yingjun Zhao, Xilin Wu, Xiaoguang Li, Lu-Lin Jiang, Xun Gui

Neuron· March 2018

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Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder

Neuron· March 2018

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SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.
Timothy Y Huang, Yingjun Zhao, Lu-Lin Jiang, Xiaoguang Li, Yan Liu

J Exp Med· December 2017

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Intracellular trafficking of TREM2 is regulated by presenilin 1.
Yingjun Zhao, Xiaoguang Li, Timothy Huang, Lu-Lin Jiang, Zhenqiu Tan

Exp Mol Med· December 2017

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ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity.
Bing Zhu, LuLin Jiang, Timothy Huang, Yingjun Zhao, Tongfei Liu

Nat Commun· November 2017

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