Publications by authors named "Lucas D Ward"

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Rare predicted loss-of-function and damaging missense variants in CFHR5 associate with protection from age-related macular degeneration.
Aaron M Holleman, Aimee M Deaton, Rachel A Hoffing, Lynne Krohn, Philip LoGerfo, Lucas D Ward

Am J Hum Genet· May 2025

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AAV-mediated hepatic expression of SLC30A10 and the Thr95Ile variant attenuates manganese excess and other phenotypes in Slc30a10-deficient mice.
Milankumar Prajapati, Chelsea B Quenneville, Jared Z Zhang, Grace S Chong, Lauren Chiu, Lucas D Ward

J Biol Chem· March 2024

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Transcript-aware analysis of rare predicted loss-of-function variants in the UK Biobank elucidate new isoform-trait associations.
Rachel A Hoffing, Aimee M Deaton, Aaron M Holleman, Lynne Krohn, Philip J LoGerfo, Lucas D Ward

Pac Symp Biocomput· January 2024

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Advancing diagnosis and management of liver disease in adults through exome sequencing.
Melanie Zheng, Aaron Hakim, Chigoziri Konkwo, Aimee M Deaton, Lucas D Ward

EBioMedicine· September 2023

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Using human genetics to improve safety assessment of therapeutics.
Keren J Carss, Aimee M Deaton, Alberto Del Rio-Espinola, Dorothée Diogo, Mark Fielden, Lucas D Ward

Nat Rev Drug Discov· February 2023

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Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.
Aimee M Deaton, Aditi Dubey, Lucas D Ward, Peter Dornbos, Jason Flannick

Nat Commun· July 2022

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Rare coding variants in DNA damage repair genes associated with timing of natural menopause.
Lucas D Ward, Margaret M Parker, Aimee M Deaton, Ho-Chou Tu, Alexander O Flynn-Carroll

HGG Adv· April 2022

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Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes.
Aimee M Deaton, Margaret M Parker, Lucas D Ward, Alexander O Flynn-Carroll, Lucas BonDurant

Sci Rep· November 2021

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A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing.
Xin Liu, Ye Zhang, Lucas D Ward, Qinghong Yan, Tanggis Bohnuud

Sci Rep· August 2021

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GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.
Lucas D Ward, Ho-Chou Tu, Chelsea B Quenneville, Shira Tsour, Alexander O Flynn-Carroll

Nat Commun· July 2021

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Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry.
Margaret M Parker, Scott M Damrauer, Catherine Tcheandjieu, David Erbe, Emre Aldinc, Lucas D Ward

Sci Rep· June 2021

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Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.
James R Turk, Aimee M Deaton, Jun Yin, Marina Stolina, Melanie Felx, Lucas D Ward

Regul Toxicol Pharmacol· August 2020

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Author Correction: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.
Phuong A Nguyen, David A Born, Aimee M Deaton, Paul Nioi, Lucas D Ward

Nat Commun· May 2019

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Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.
Phuong A Nguyen, David A Born, Aimee M Deaton, Paul Nioi, Lucas D Ward

Nat Commun· April 2019

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Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence.
Aimee M Deaton, Fan Fan, Wei Zhang, Phuong A Nguyen, Lucas D Ward

Toxicol Sci· February 2019

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Comment on "Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors".
Lucas D Ward, Graeme J Moffat, Jing Yuan, Paul Nioi

Drug Saf· November 2018

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Modernizing Human Cancer Risk Assessment of Therapeutics.
Mark R Fielden, Lucas D Ward, Sheroy Minocherhomji, Paul Nioi, Herve Lebrec

Trends Pharmacol Sci· March 2018

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A rare missense variant in associates with lower cholesterol levels.
Aimee M Deaton, Patrick Sulem, Paul Nioi, Stefania Benonisdottir, Lucas D Ward

Commun Biol· February 2018

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Whole genome characterization of sequence diversity of 15,220 Icelanders.
Hákon Jónsson, Patrick Sulem, Birte Kehr, Snaedis Kristmundsdottir, Florian Zink, Lucas D Ward

Sci Data· September 2017

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Parental influence on human germline de novo mutations in 1,548 trios from Iceland.
Hákon Jónsson, Patrick Sulem, Birte Kehr, Snaedis Kristmundsdottir, Florian Zink, Lucas D Ward

Nature· September 2017

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Epigenetic and genetic components of height regulation.
Stefania Benonisdottir, Asmundur Oddsson, Agnar Helgason, Ragnar P Kristjansson, Gardar Sveinbjornsson, Lucas D Ward

Nat Commun· November 2016

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HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease.
Lucas D Ward, Manolis Kellis

Nucleic Acids Res· January 2016

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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Suna Onengut-Gumuscu, Wei-Min Chen, Oliver Burren, Nick J Cooper, Aaron R Quinlan, Lucas D Ward

Nat Genet· April 2015

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Integrative analysis of 111 reference human epigenomes.

Nature· February 2015

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