Publications by authors named "Madeleine Fletcher"

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Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors.
Grace Mennen, Zi Ying, Madeleine M Fletcher, Muhammad Abdur Razzak, Laura Humphrys

Biochemistry· June 2025

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Structural insight into selectivity of amylin and calcitonin receptor agonists.
Jianjun Cao, Matthew J Belousoff, Elliot Gerrard, Radostin Danev, Madeleine M Fletcher

Nat Chem Biol· February 2024

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Molecular insights into peptide agonist engagement with the PTH receptor.
Brian P Cary, Elliot J Gerrard, Matthew J Belousoff, Madeleine M Fletcher, Yan Jiang

Structure· June 2023

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Understanding VPAC receptor family peptide binding and selectivity.
Sarah J Piper, Giuseppe Deganutti, Jessica Lu, Peishen Zhao, Yi-Lynn Liang, Madeleine M Fletcher

Nat Commun· November 2022

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A structural basis for amylin receptor phenotype.
Jianjun Cao, Matthew J Belousoff, Yi-Lynn Liang, Rachel M Johnson, Tracy M Josephs, Madeleine M Fletcher

Science· March 2022

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AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists.
Madeleine M Fletcher, Peter Keov, Tin T Truong, Grace Mennen, Caroline A Hick

J Pharmacol Exp Ther· June 2021

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Structure and Dynamics of Adrenomedullin Receptors AM and AM Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Yi-Lynn Liang, Matthew J Belousoff, Madeleine M Fletcher, Xin Zhang, Maryam Khoshouei

ACS Pharmacol Transl Sci· April 2020

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Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Yi-Lynn Liang, Matthew J Belousoff, Peishen Zhao, Cassandra Koole, Madeleine M Fletcher

Mol Cell· February 2020

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Activation of the GLP-1 receptor by a non-peptidic agonist.
Peishen Zhao, Yi-Lynn Liang, Matthew J Belousoff, Giuseppe Deganutti, Madeleine M Fletcher

Nature· January 2020

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Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists.
Madeleine M Fletcher, Michelle L Halls, Peishen Zhao, Lachlan Clydesdale, Arthur Christopoulos

Biochem Pharmacol· October 2018

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Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.
Chris de Graaf, Dan Donnelly, Denise Wootten, Jesper Lau, Patrick M Sexton, Madeleine M Fletcher

Pharmacol Rev· October 2016

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The complexity of signalling mediated by the glucagon-like peptide-1 receptor.
Madeleine M Fletcher, Michelle L Halls, Arthur Christopoulos, Patrick M Sexton, Denise Wootten

Biochem Soc Trans· April 2016

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Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism.
Renata Kowalczyk, Margaret A Brimble, Yusuke Tomabechi, Antony J Fairbanks, Madeleine Fletcher

Org Biomol Chem· November 2014

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Outbreaks of adult gastroenteritis traced to a single genotype of rotavirus.
Dixie D Griffin, Madeleine Fletcher, Martin E Levy, Myra Ching-Lee, Robert Nogami

J Infect Dis· May 2002

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