Publications by authors named "Malcolm Shepherd"

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Corticosteroid Responsiveness Following Mepolizumab in Severe Eosinophilic Asthma-A Randomized, Placebo-Controlled Crossover Trial (MAPLE).
Freda Yang, John Busby, Liam G Heaney, Ian D Pavord, Chris E Brightling, Malcolm Shepherd

J Allergy Clin Immunol Pract· November 2022

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Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations.
Jieqiong Freda Yang, Rekha Chaudhuri, Neil C Thomson, Nitish Ramparsad, Hugh O'Pray, Malcolm Shepherd

NPJ Prim Care Respir Med· September 2018

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Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma.
Rekha Chaudhuri, Charles McSharry, Liam G Heaney, Robert Niven, Christopher E Brightling, Malcolm Shepherd

Respir Med· September 2016

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Corticosteroid insensitivity in smokers with asthma : clinical evidence, mechanisms, and management.
Neil C Thomson, Malcolm Shepherd, Mark Spears, Rekha Chaudhuri

Treat Respir Med· April 2016

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Effectiveness of bronchial thermoplasty in severe asthma in 'real life' patients compared with those recruited to clinical trials in the same centre.
Stephen Bicknell, Rekha Chaudhuri, Nicola Lee, Malcolm Shepherd, Mark Spears

Ther Adv Respir Dis· December 2015

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Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor.
Fiona M Menzies, Claire A Higgins, Malcolm C Shepherd, Robert J B Nibbs, Scott M Nelson

Immunol Cell Biol· March 2012

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Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity.
Rekha Chaudhuri, Charles McSharry, Jeffrey Brady, Iona Donnelly, Christal Grierson, Malcolm C Shepherd

J Allergy Clin Immunol· March 2012

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Functional expression of IgG-Fc receptors in human airway smooth muscle cells.
YuXiu C Xia, Michael Schuliga, Malcolm Shepherd, Maree Powell, Trudi Harris

Am J Respir Cell Mol Biol· May 2011

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IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.
Mariola Kurowska-Stolarska, Bartosz Stolarski, Peter Kewin, Grace Murphy, Christopher J Corrigan, Malcolm Shepherd

J Immunol· November 2009

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Ion channel regulation of intracellular calcium and airway smooth muscle function.
Jose F Perez-Zoghbi, Charlotta Karner, Satoru Ito, Malcolm Shepherd, Yazan Alrashdan

Pulm Pharmacol Ther· October 2009

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KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation.
Malcolm C Shepherd, S Mark Duffy, Trudi Harris, Glenn Cruse, Michael Schuliga

Am J Respir Cell Mol Biol· November 2007

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Phosphodiesterase 4 regulation of cyclic AMP in pulmonary remodelling: potential roles for isoform selective inhibitors.
Malcolm C Shepherd

Pulm Pharmacol Ther· May 2006

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Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers.
Rachael Barber, George S Baillie, Reinhard Bergmann, Malcolm C Shepherd, Ruth Sepper

Am J Physiol Lung Cell Mol Physiol· August 2004

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Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.
Malcolm C Shepherd, George S Baillie, David I Stirling, Miles D Houslay

Br J Pharmacol· May 2004

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Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
Malcolm Shepherd, Theresa McSorley, Aileen E Olsen, Lee Ann Johnston, Neil C Thomson

Biochem J· March 2003

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Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter.
Ivan R Le Jeune, Malcolm Shepherd, Gino Van Heeke, Miles D Houslay, Ian P Hall

J Biol Chem· September 2002

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