Publications by authors named "Margien Seinen"

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Exploring the role of oxidative stress and the effect of N-acetylcysteine in thiopurine-induced liver injury in inflammatory bowel disease: A randomized crossover pilot study.
Dirk P van Asseldonk, Femke Crouwel, Margien L Seinen, Peter G Scheffer, Agnes I Veldkamp

Basic Clin Pharmacol Toxicol· April 2024

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Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease.
Femke Crouwel, Melek Simsek, Marjon A de Boer, Chris J J Mulder, Emma M van Andel, Margien L Seinen

J Crohns Colitis· May 2023

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Electronic Nose Sensor Drift Affects Diagnostic Reliability and Accuracy of Disease-Specific Algorithms.
Sofie Bosch, Renée X de Menezes, Suzanne Pees, Dion J Wintjens, Margien Seinen

Sensors (Basel)· November 2022

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The continuous rediscovery and the benefit-risk ratio of thioguanine, a comprehensive review.
Ahmed B Bayoumy, Melek Simsek, Margien L Seinen, Chris J J Mulder, Azhar Ansari

Expert Opin Drug Metab Toxicol· February 2020

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Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies.
Melek Simsek, Debbie S Deben, Carmen S Horjus, Melanie V Bénard, Birgit I Lissenberg-Witte, Margien L Seinen

Aliment Pharmacol Ther· July 2019

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High inter-individual variability of serum xanthine oxidoreductase activity in IBD patients.
Berrie Meijer, Margien L Seinen, Tessa Hosman, Ronald K Linskens, Jan-Kees Kneppelhout

Nucleosides Nucleotides Nucleic Acids· May 2019

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Key insights from therapeutic drug monitoring in Crohn's disease patients.
Margien L Seinen, Nanne K De Boer, Adriaan A van Bodegraven

Expert Opin Drug Metab Toxicol· May 2019

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Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
Rebecca L Roberts, Mary C Wallace, Margien L Seinen, Adriaan A van Bodegraven, Krupa Krishnaprasad

Inflamm Bowel Dis· November 2018

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Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol-thiopurine cotherapy.
Melek Simsek, Margien L Seinen, Nanne K H de Boer

Eur J Gastroenterol Hepatol· October 2018

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Optimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?
Berrie Meijer, Margien L Seinen, Remco van Egmond, Gerd Bouma, Chris J J Mulder

Inflamm Bowel Dis· November 2017

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Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol-Thiopurine Combination Therapy.
Margien L Seinen, Dirk P van Asseldonk, Nanne K de Boer, Gerd Bouma, Carin M van Nieuwkerk

Inflamm Bowel Dis· March 2017

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A plea for TDM-based optimisation for treatment of Crohn's disease.
Margien L Seinen, Nanne K de Boer

Lancet Gastroenterol Hepatol· February 2017

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Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy.
Margien L Seinen, Geerten P van Nieuw Amerongen, Nanne K H de Boer, Adriaan A van Bodegraven

Mol Diagn Ther· December 2016

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Rac1 as a Potential Pharmacodynamic Biomarker for Thiopurine Therapy in Inflammatory Bowel Disease.
Margien L Seinen, Geerten P van Nieuw Amerongen, Nanne K H de Boer, Chris J J Mulder, Jan van Bezu

Ther Drug Monit· October 2016

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Clinical Value of Mercaptopurine After Failing Azathioprine Therapy in Patients With Inflammatory Bowel Disease.
Berrie Meijer, Margien L Seinen, Niek N W Leijte, Chris J J Mulder, Adriaan A van Bodegraven

Ther Drug Monit· August 2016

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Routinely Established Skewed Thiopurine Metabolism Leads to a Strikingly High Rate of Early Therapeutic Failure in Patients With Inflammatory Bowel Disease.
Joany E Kreijne, Margien L Seinen, Abraham J Wilhelm, Gerd Bouma, Chris J Mulder

Ther Drug Monit· December 2015

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PACSIN2 does not influence thiopurine-related toxicity in patients with inflammatory bowel disease.
Rebecca L Roberts, Mary C Wallace, Margien L Seinen, Krupa Krishnaprasad, Angela Chew

Am J Gastroenterol· June 2014

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Reply: To PMID 23333660.
Margien L Seinen, Nanne K H De Boer, Adriaan A van Bodegraven

Clin Gastroenterol Hepatol· August 2013

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Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with Crohn's disease.
Margien L Seinen, Cyriel Y Ponsioen, Nanne K H de Boer, Bas Oldenburg, Gerd Bouma

Clin Gastroenterol Hepatol· June 2013

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Safety and effectiveness of long-term allopurinol-thiopurine maintenance treatment in inflammatory bowel disease.
Frank Hoentjen, Margien L Seinen, Stephen B Hanauer, Nanne K H de Boer, David T Rubin

Inflamm Bowel Dis· February 2013

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Oxidation-mediated DNA crosslinking contributes to toxicity of 6-thioguanine in human cells -- letter.
Nanne K H de Boer, Dirk P van Asseldonk, Margien L Seinen, Adriaan A van Bodegraven

Cancer Res· February 2013

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Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.
Dirk P van Asseldonk, Margien L Seinen, Nanne K H de Boer, Ad A van Bodegraven, Chris J Mulder

J Crohns Colitis· February 2012

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Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series.
Margien L Seinen, Nanne K H de Boer, Kees Smid, Dirk P van Asseldonk, Gerd Bouma

Nucleosides Nucleotides Nucleic Acids· December 2011

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Dosing 6-thioguanine in inflammatory bowel disease: expert-based guidelines for daily practice.
Margien L Seinen, Dirk P van Asseldonk, Chris J J Mulder, Nanne K H de Boer

J Gastrointestin Liver Dis· September 2010

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