Publications by authors named "Maria C Castiello"

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Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency.
Maria Carmina Castiello, Chiara Brandas, Samuele Ferrari, Simona Porcellini, Nicolò Sacchetti

Sci Transl Med· February 2024

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Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying hypomorphic mutations.
Maria Carmina Castiello, Martina Di Verniere, Elena Draghici, Elena Fontana, Sara Penna

Front Immunol· December 2023

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Correcting inborn errors of immunity: From viral mediated gene addition to gene editing.
Maria Carmina Castiello, Samuele Ferrari, Anna Villa

Semin Immunol· March 2023

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HyperIgE in hypomorphic recombination-activating gene defects.
Maria Carmina Castiello, Chiara Brandas, Valentina Capo, Anna Villa

Curr Opin Immunol· February 2023

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Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells.
Samuele Ferrari, Aurelien Jacob, Daniela Cesana, Marianne Laugel, Stefano Beretta, Maria Carmina Castiello

Cell Stem Cell· October 2022

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Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency.
Francesca Ferrua, Ileana Bortolomai, Elena Fontana, Dario Di Silvestre, Rosita Rigoni, Maria Carmina Castiello

Front Immunol· October 2021

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Innovative Cell-Based Therapies and Conditioning to Cure RAG Deficiency.
Anna Villa, Valentina Capo, Maria Carmina Castiello

Front Immunol· June 2021

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Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
Valentina Vavassori, Elisabetta Mercuri, Genni E Marcovecchio, Maria C Castiello, Giulia Schiroli

EMBO Mol Med· March 2021

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Gene Editing of Hematopoietic Stem Cells: Hopes and Hurdles Toward Clinical Translation.
Samuele Ferrari, Valentina Vavassori, Daniele Canarutto, Aurelien Jacob, Maria Carmina Castiello

Front Genome Ed· March 2021

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Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency.
Maria Carmina Castiello, Marita Bosticardo, Nicolò Sacchetti, Enrica Calzoni, Elena Fontana

J Allergy Clin Immunol· January 2021

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Lentiviral gene therapy corrects platelet phenotype and function in patients with Wiskott-Aldrich syndrome.
Lucia Sereni, Maria Carmina Castiello, Dario Di Silvestre, Patrizia Della Valle, Chiara Brombin

J Allergy Clin Immunol· September 2019

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Neutrophils drive type I interferon production and autoantibodies in patients with Wiskott-Aldrich syndrome.
Karla E Cervantes-Luevano, Nicoletta Caronni, Maria C Castiello, Elena Fontana, Giulia M Piperno

J Allergy Clin Immunol· November 2018

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Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation.
Lucia Sereni, Maria Carmina Castiello, Francesco Marangoni, Achille Anselmo, Dario di Silvestre

J Allergy Clin Immunol· October 2018

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Efficacy of lentivirus-mediated gene therapy in an Omenn syndrome recombination-activating gene 2 mouse model is not hindered by inflammation and immune dysregulation.
Valentina Capo, Maria Carmina Castiello, Elena Fontana, Sara Penna, Marita Bosticardo

J Allergy Clin Immunol· September 2018

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Platelets in Wiskott-Aldrich syndrome: Victims or executioners?
Lucia Sereni, Maria Carmina Castiello, Anna Villa

J Leukoc Biol· March 2018

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Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1.
Giulia Schiroli, Samuele Ferrari, Anthony Conway, Aurelien Jacob, Valentina Capo, Maria C Castiello

Sci Transl Med· October 2017

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Chronic Stimulation Unveils Autoreactive Potential of Wiskott-Aldrich Syndrome Protein-Deficient B Cells.
Maria Carmina Castiello, Francesca Pala, Lucia Sereni, Elena Draghici, Donato Inverso

Front Immunol· May 2017

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Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects.
Rosita Rigoni, Elena Fontana, Simone Guglielmetti, Bruno Fosso, Anna Maria D'Erchia, Maria Carmina Castiello

J Exp Med· March 2016

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Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients.
Francesca Pala, Henner Morbach, Maria Carmina Castiello, Jean-Nicolas Schickel, Samantha Scaramuzza

J Clin Invest· October 2015

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B-cell reconstitution after lentiviral vector-mediated gene therapy in patients with Wiskott-Aldrich syndrome.
Maria Carmina Castiello, Samantha Scaramuzza, Francesca Pala, Francesca Ferrua, Paolo Uva

J Allergy Clin Immunol· September 2015

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IL-10 critically modulates B cell responsiveness in Rankl-/- mice.
Veronica Marrella, Nadia Lo Iacono, Elena Fontana, Cristina Sobacchi, Heiko Sic, Maria Carmina Castiello

J Immunol· May 2015

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Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans.
Maria Carmina Castiello, Marita Bosticardo, Francesca Pala, Marco Catucci, Nicolas Chamberlain

J Autoimmun· May 2014

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Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity.
Marco Catucci, Ivan Zanoni, Elena Draghici, Marita Bosticardo, Maria C Castiello

Eur J Immunol· April 2014

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B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients.
Immacolata Brigida, Aisha V Sauer, Francesca Ferrua, Stefania Giannelli, Samantha Scaramuzza, Maria Carmina Castiello

J Allergy Clin Immunol· March 2014

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Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.
Alessandro Aiuti, Luca Biasco, Samantha Scaramuzza, Francesca Ferrua, Maria Pia Cicalese, Maria Carmina Castiello

Science· August 2013

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