Publications by authors named "Maria Carr"

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Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Swee Y Sharp, Marianna Martella, Sabrina D'Agostino, Christopher I Milton, George Ward, Maria G Carr

Nat Commun· November 2024

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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
David Norton, William G Bonnette, James F Callahan, Maria G Carr, Charlotte M Griffiths-Jones

J Med Chem· November 2021

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Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Tom D Heightman, Valerio Berdini, Luke Bevan, Ildiko M Buck, Maria G Carr

J Med Chem· August 2021

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Multicenter Study Evaluating Intrarenal Oxygenation and Fibrosis Using Magnetic Resonance Imaging in Individuals With Advanced CKD.
Pottumarthi V Prasad, Wei Li, Dominic S Raj, James Carr, Maria Carr

Kidney Int Rep· November 2018

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Accelerated real-time cardiac MRI using iterative sparse SENSE reconstruction: comparing performance in patients with sinus rhythm and atrial fibrillation.
Bradley D Allen, Maria L Carr, Michael Markl, Michael O Zenge, Michaela Schmidt, James C Carr

Eur Radiol· July 2018

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The consistency of myocardial strain derived from heart deformation analysis.
Eric J Keller, Shanna Fang, Kai Lin, Benjamin H Freed, Peter M Smith, Maria Carr, James C Carr

Int J Cardiovasc Imaging· August 2017

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Three-dimensional left atrial blood flow characteristics in patients with atrial fibrillation assessed by 4D flow CMR.
Daniel C Lee, Michael Markl, Jason Ng, Maria Carr, Brandon Benefield, James C Carr

Eur Heart J Cardiovasc Imaging· November 2016

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Altered aortic shape in bicuspid aortic valve relatives influences blood flow patterns.
Susanne Schnell, Danielle A Smith, Alex J Barker, Pegah Entezari, Amir R Honarmand, Maria L Carr, James C Carr

Eur Heart J Cardiovasc Imaging· November 2016

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Left Atrial and Left Atrial Appendage 4D Blood Flow Dynamics in Atrial Fibrillation.
Michael Markl, Daniel C Lee, Nicholas Furiasse, Maria Carr, Charles Foucar, James Carr

Circ Cardiovasc Imaging· September 2016

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Right ventricular assessment at cardiac MRI: initial clinical experience utilizing an IS-SENSE reconstruction.
Abraham Bogachkov, Jad Bou Ayache, Bradley D Allen, Ian Murphy, Maria L Carr, James C Carr

Int J Cardiovasc Imaging· July 2016

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Highly accelerated cardiac MRI using iterative SENSE reconstruction: initial clinical experience.
Bradley D Allen, Maria Carr, Marcos P F Botelho, Amir Ali Rahsepar, Michael Markl, James C Carr

Int J Cardiovasc Imaging· June 2016

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Assessment of left and right atrial 3D hemodynamics in patients with atrial fibrillation: a 4D flow MRI study.
Michael Markl, Maria Carr, Jason Ng, Daniel C Lee, Kelly Jarvis, James Carr

Int J Cardiovasc Imaging· May 2016

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Left Atrial 4-Dimensional Flow Magnetic Resonance Imaging: Stasis and Velocity Mapping in Patients With Atrial Fibrillation.
Michael Markl, Daniel C Lee, Jason Ng, Maria Carr, James Carr

Invest Radiol· March 2016

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Thoracic aorta 3D hemodynamics in pediatric and young adult patients with bicuspid aortic valve.
Bradley D Allen, Pim van Ooij, Alex J Barker, Maria Carr, Maya Gabbour, James C Carr

J Magn Reson Imaging· October 2015

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Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
Christopher W Murray, Valerio Berdini, Ildiko M Buck, Maria E Carr, Anne Cleasby

ACS Med Chem Lett· July 2015

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Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy.
Pim van Ooij, Wouter V Potters, Jeremy Collins, Maria Carr, James Carr

Ann Biomed Eng· June 2015

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Three-dimensional hemodynamics in intracranial aneurysms: influence of size and morphology.
Susanne Schnell, Sameer A Ansari, Parmede Vakil, Marie Wasielewski, Maria L Carr, Timothy J Carroll, James Carr

J Magn Reson Imaging· January 2014

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Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.
Susanne M Saalau-Bethell, Andrew J Woodhead, Gianni Chessari, Maria G Carr, Joseph Coyle

Nat Chem Biol· November 2012

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Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.
Matthew Squires, George Ward, Gordan Saxty, Valerio Berdini, Anne Cleasby, Maria Carr

Mol Cancer Ther· September 2011

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Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Andrew J Woodhead, Hayley Angove, Maria G Carr, Gianni Chessari, Miles Congreve

J Med Chem· August 2010

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Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
Christopher W Murray, Maria G Carr, Owen Callaghan, Gianni Chessari, Miles Congreve

J Med Chem· August 2010

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Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.
Steven Howard, Valerio Berdini, John A Boulstridge, Maria G Carr, David M Cross

J Med Chem· January 2009

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Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Paul G Wyatt, Andrew J Woodhead, Valerio Berdini, John A Boulstridge, Maria G Carr

J Med Chem· August 2008

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Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
Adrian L Gill, Martyn Frederickson, Anne Cleasby, Steven J Woodhead, Maria G Carr, Robin A E Carr

J Med Chem· January 2005

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Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase.
Rebekah Beevers, Maria G Carr, Philip S Jones, Steven Jordan, Paul B Kay

Bioorg Med Chem Lett· February 2002

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