Publications by authors named "Maria L Webb"

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Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB).
Jeffrey J Letourneau, Ilana L Stroke, David W Hilbert, Andrew G Cole, Laurie J Sturzenbecker, Maria L Webb

Bioorg Med Chem Lett· December 2018

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Treatment of Clostridium difficile Infection with a Small-Molecule Inhibitor of Toxin UDP-Glucose Hydrolysis Activity.
Ilana L Stroke, Jeffrey J Letourneau, Teresa E Miller, Yan Xu, Igor Pechik, Maria L Webb

Antimicrob Agents Chemother· May 2018

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Identification and initial optimization of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB).
Jeffrey J Letourneau, Ilana L Stroke, David W Hilbert, Laurie J Sturzenbecker, Brett A Marinelli, Maria L Webb

Bioorg Med Chem Lett· February 2018

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Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3.
Belinda Nedjai, Hubert Li, Ilana L Stroke, Emma L Wise, Maria L Webb

Br J Pharmacol· June 2012

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Identification of a novel allosteric binding site in the CXCR2 chemokine receptor.
Petra de Kruijf, Herman D Lim, Luc Roumen, Véronique A Renjaän, Jiuqiao Zhao, Maria L Webb

Mol Pharmacol· December 2011

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Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Susan E Napier, Jeffrey J Letourneau, Nasrin Ansari, Douglas S Auld, James Baker, Maria L Webb

Bioorg Med Chem Lett· June 2011

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Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Susan E Napier, Jeffrey J Letourneau, Nasrin Ansari, Douglas S Auld, James Baker, Maria L Webb

Bioorg Med Chem Lett· March 2011

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Current strategies in lead discovery.
Maria L Webb

Curr Pharm Biotechnol· November 2010

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Novel pyrrolidine heterocycles as CCR1 antagonists.
J Robert Merritt, Ray James, Vidyadhar M Paradkar, Chongwu Zhang, Ruiyan Liu, Maria L Webb

Bioorg Med Chem Lett· September 2010

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Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists.
Jeffrey J Letourneau, Christopher M Riviello, Hong Li, Andrew G Cole, Koc-Kan Ho, Maria L Webb

Bioorg Med Chem Lett· September 2010

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Identification and hit-to-lead optimization of a novel class of CB1 antagonists.
Jeffrey J Letourneau, Patrick Jokiel, John Olson, Christopher M Riviello, Koc-Kan Ho, Maria L Webb

Bioorg Med Chem Lett· September 2010

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Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
Tsung H Lin, Martin Hegen, Elizabeth Quadros, Cheryl L Nickerson-Nutter, Kenneth C Appell, Maria L Webb

Arthritis Rheum· August 2010

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2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
Andrew G Cole, Adolph C Bohnstedt, Vidyadhar Paradkar, Celia Kingsbury, Jorge G Quintero, Maria L Webb

Bioorg Med Chem Lett· December 2009

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Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists.
J Robert Merritt, Jinqi Liu, Elizabeth Quadros, Michelle L Morris, Ruiyan Liu, Maria L Webb

J Med Chem· March 2009

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Synthesis and initial evaluation of novel, non-peptidic antagonists of the alpha(v)-integrins alpha(v)beta(3) and alpha(v)beta(5).
Jeffrey J Letourneau, Jinqi Liu, Michael H J Ohlmeyer, Chris Riviello, Yajing Rong, Maria L Webb

Bioorg Med Chem Lett· January 2009

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Synthesis of (3,4-dimethoxyphenoxy)alkylamino acetamides as orexin-2 receptor antagonists.
Andrew G Cole, Ilana L Stroke, Lan-Ying Qin, Zahid Hussain, Srilatha Simhadri, Maria L Webb

Bioorg Med Chem Lett· October 2008

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Kinase inhibitors as drugs for chronic inflammatory and immunological diseases: progress and challenges.
Laura L Rokosz, James R Beasley, Carolyn Diianni Carroll, Tsung Lin, Jiuqiao Zhao, Maria L Webb

Expert Opin Ther Targets· July 2008

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Identification and characterization of small-molecule inhibitors of Tie2 kinase.
Jinqi Liu, Tsung H Lin, Andrew G Cole, Rong Wen, Lian Zhao, Maria L Webb

FEBS Lett· March 2008

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Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists.
Marc-Raleigh Brescia, Laura L Rokosz, Andrew G Cole, Tara M Stauffer, John M Lehrach, Maria L Webb

Bioorg Med Chem Lett· March 2007

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Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries.
Ilana L Stroke, Andrew G Cole, Srilatha Simhadri, Marc-Raleigh Brescia, Madhuri Desai, Maria L Webb

Biochem Biophys Res Commun· October 2006

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Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors.
Tsung H Lin, Axel Metzger, David J Diller, Madhuri Desai, Ian Henderson, Maria L Webb

J Pharmacol Exp Ther· August 2006

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Successful screening of large encoded combinatorial libraries leading to the discovery of novel p38 MAP kinase inhibitors.
Axel Metzger, David J Diller, Tsung H Lin, Ian Henderson, Maria L Webb

Comb Chem High Throughput Screen· June 2006

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Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists.
Andrew G Cole, Ilana L Stroke, Marc-Raleigh Brescia, Srilatha Simhadri, Joan J Zhang, Maria L Webb

Bioorg Med Chem Lett· January 2006

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Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis.
Tao Guo, Anton E P Adang, Roland E Dolle, Guizhen Dong, Dan Fitzpatrick, Maria L Webb

Bioorg Med Chem Lett· April 2004

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Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis.
Tao Guo, Anton E P Adang, Guizhen Dong, Dan Fitzpatrick, Peng Geng, Maria L Webb

Bioorg Med Chem Lett· April 2004

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