Publications by authors named "Maria Posada"

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A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules.
Maria M Posada, Karen B Schneck, Bridget L Morse, Luc R A Rougee, Lai San Tham

CPT Pharmacometrics Syst Pharmacol· December 2025

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Fluid Overload and Outcomes in Pediatric Patients With Moderate or Severe Traumatic Brain Injury: Single-Center, Retrospective Cohort Study in Colombia.
Rubén E Lasso-Palomino, Camila Ariza-Insignares, Brandon Barrios, María J Lopez, María J Soto-Aparicio, Maria A Posada

Pediatr Crit Care Med· December 2025

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Application of Physiologically-Based Pharmacokinetic Modeling to Support Drug Labeling: Prediction of CYP3A4-Mediated Pirtobrutinib-Drug Interactions.
Dan-Dan Tian, Stephen D Hall, Sonya C Chapman, Maria M Posada

CPT Pharmacometrics Syst Pharmacol· December 2025

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Comparison of Regression and Categorical Analysis for Pharmacokinetic Data From Renal Impairment Studies.
Gerald Chun-To So, Ying Grace Li, Stephen D Hall, Jenny Chien, Christopher D Payne, Maria M Posada

Clin Pharmacol Ther· October 2025

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Opportunities and Challenges of Hepatic Impairment Physiologically Based Pharmacokinetic Modeling in Drug Development-An IQ Perspective.
Hisham Qosa, Islam R Younis, Vaishali Sahasrabudhe, Ashish Sharma, Jin Yan, Maria M Posada

Clin Pharmacol Ther· June 2025

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Intracranial hypertension as the first manifestation of systemic lupus erythematosus: A case report.
Isabella Pugliese, María Posada, Masaru Shinchi, David Aguirre-Valencia

Heliyon· October 2024

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Investigation of the Effect of Lasmiditan on the Pharmacokinetics of P-Glycoprotein and Breast Cancer Resistance Protein Substrates.
Debra Luffer-Atlas, Darren Wilbraham, Maria M Posada, John Landry, Max Tsai

J Clin Pharmacol· January 2024

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Prediction of the Renal Organic Anion Transporter 1 (OAT1)- Mediated Drug Interactions for LY404039, the Active Metabolite of Pomaglumetad Methionil.
Y Anne Pak, Maria M Posada, James Bacon, Amanda Long, William Annes

Pharm Res· November 2023

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Identification of CD8 T cell subsets that normalize in early-treated people living with HIV receiving antiretroviral therapy.
Federico Perdomo-Celis, David Arcia-Anaya, Juan Carlos Alzate, Paula A Velilla, Francisco J Díaz, Maria Paulina Posada

AIDS Res Ther· September 2022

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DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2-COX-2-TP Axis and NLRP3 Inflammasome Activation.
Inés Valencia, Susana Vallejo, Pilar Dongil, Alejandra Romero, Álvaro San Hipólito-Luengo, María Posada

Hypertension· July 2022

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Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile.
Junliang Hao, James Beck, Xin Zhou, Gregory L Lackner, Richard Johnston, Maria Posada

J Med Chem· March 2022

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Right-sided Bochdalek hernia associated with an intrathoracic kidney in an adult.
Gabriel Salcedo, Felipe Velez, Maria Posada, Cristina Barragan, Peter Vorwald

Surgery· October 2021

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Development and Application of a Mechanistic Population Modeling Approach to Describe Abemaciclib Pharmacokinetics.
Emmanuel Chigutsa, Siva Rama Prasad Kambhampati, Amanda Karen Sykes, Maria M Posada, Jan-Stefan van der Walt

CPT Pharmacometrics Syst Pharmacol· September 2020

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Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling.
Maria M Posada, Bridget L Morse, P Kellie Turner, Palaniappan Kulanthaivel, Stephen D Hall

J Clin Pharmacol· July 2020

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Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.
Kunal S Taskar, Venkatesh Pilla Reddy, Howard Burt, Maria M Posada, Manthena Varma

Clin Pharmacol Ther· May 2020

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The Effect of Promiscuous Aggregation on in Vitro Drug Metabolism Assays.
Francesco Tres, Maria M Posada, Stephen D Hall, Michael A Mohutsky, Lynne S Taylor

Pharm Res· October 2019

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Physiologically-Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid-to-Lactone Conversion.
Bridget L Morse, Jeffrey J Alberts, Maria M Posada, Jessica Rehmel, Anil Kolur

CPT Pharmacometrics Syst Pharmacol· September 2019

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Impact of Biliopancreatic Limb Length (70 cm vs 120 cm), with Constant 150 cm Alimentary Limb, on Long-Term Weight Loss, Remission of Comorbidities and Supplementation Needs After Roux-En-Y Gastric Bypass: a Prospective Randomized Clinical Trial.
Jaime Ruiz-Tovar, Peter Vorwald, Gilberto Gonzalez-Ramirez, María Posada, Gabriel Salcedo

Obes Surg· August 2019

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Evaluation of the effects of an oral notch inhibitor, crenigacestat (LY3039478), on QT interval, and bioavailability studies conducted in healthy subjects.
Eunice Yuen, Maria Posada, Claire Smith, Katharine Thorn, Dale Greenwood

Cancer Chemother Pharmacol· March 2019

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Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam.
Everett J Perkins, Maria Posada, P Kellie Turner, Jill Chappell, Wee Teck Ng

Eur J Drug Metab Pharmacokinet· June 2018

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Mechanistic understanding of the phase behavior of supersaturated solutions of poorly water-soluble drugs.
Francesco Tres, Maria M Posada, Stephen D Hall, Michael A Mohutsky, Lynne S Taylor

Int J Pharm· May 2018

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Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib.
Maria M Posada, Ellen A Cannady, Christopher D Payne, Xin Zhang, James A Bacon

Clin Transl Sci· November 2017

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Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.
Daniel Scotcher, Christopher Jones, Maria Posada, Amin Rostami-Hodjegan, Aleksandra Galetin

AAPS J· September 2016

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Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation.
Daniel Scotcher, Christopher Jones, Maria Posada, Aleksandra Galetin, Amin Rostami-Hodjegan

AAPS J· September 2016

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