Publications by authors named "Maria Walczak"

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Fine-tuning 5-HT receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy)ethyl-piperidines toward antidepressant and pro-cognitive properties.
Vittorio Canale, Klaudia Blicharz-Futera, Monika Bijata, Natalie G Cavalco, Anna Partyka, Maria Walczak

Eur J Med Chem· January 2026

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Distinct patterns of endothelial response to endotoxin in aged mice as compared to young mice.
Joanna Suraj-Prażmowska, Magdalena Sternak, Anna Kurpińska, Anna Bar, Izabela Czyżyńska-Cichoń, Maria Walczak

Geroscience· November 2025

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Zolpidem suppresses cortical spreading depolarization and protects against ischemia/reperfusion injury and resulting neurological dysfunctions.
Bartosz Pomierny, Mateusz W Kucharczyk, Weronika Krzyżanowska, Alicja Skórkowska, Jakub Jurczyk, Maria Walczak

Biomed Pharmacother· August 2025

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Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke.
Barbara Mordyl, Nikola Fajkis-Zajączkowska, Katarzyna Szafrańska, Agata Siwek, Monika Głuch-Lutwin, Maria Walczak

J Med Chem· December 2024

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Method Validation for the Determination of Ciprofloxacin in Lucilia sericata Larvae via Capillary Electrophoresis Combined With Mass Spectrometry.
Magdalena Czuma-Pokusa, Maria Walczak

Electrophoresis· November 2024

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Physiologically based pharmacokinetic modeling of CYP2C8 substrate rosiglitazone and its metabolite to predict metabolic drug-drug interaction.
Nilesh Gaud, Dawid Gogola, Anna Kowal-Chwast, Ewelina Gabor-Worwa, Peter Littlewood, Maria Walczak

Drug Metab Pharmacokinet· August 2024

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Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice.
Agnieszka Kij, Anna Bar, Izabela Czyzynska-Cichon, Kamil Przyborowski, Bartosz Proniewski, Maria Walczak

Acta Physiol (Oxf)· April 2024

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Superiority of the Triple-Acting 5-HTR/5-HTR Antagonist and MAO-B Reversible Inhibitor over 5-HTR Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats.
Katarzyna Grychowska, Uriel López-Sánchez, Mathieu Vitalis, Geoffrey Canet, Grzegorz Satała, Maria Walczak

J Med Chem· November 2023

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Metabolic and cardiovascular benefits and risks of 4-hydroxy guanabenz hydrochloride: α-adrenoceptor and trace amine-associated receptor 1 ligand.
Magdalena Kotańska, Monika Marcinkowska, Kamil J Kuder, Maria Walczak, Marek Bednarski

Pharmacol Rep· October 2023

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COVID-19-related social isolation and symptoms of depression and anxiety in young men in Poland: Does insomnia mediate the relationship?
Justyna Mojsa-Kaja, Klaudia Szklarczyk-Smolana, Ewa Niedzielska-Andres, Anna Kurpińska, Joanna Suraj-Prażmowska, Maria Walczak

PLoS One· May 2023

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Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Dawid Panek, Anna Pasieka, Gniewomir Latacz, Paula Zaręba, Michał Szczęch, Maria Walczak

Eur J Med Chem· March 2023

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Promising anticonvulsant and/or analgesic compounds among 5-chloro-2- or 5-chloro-4-methyl derivatives of xanthone coupled to aminoalkanol moieties-Design, synthesis and pharmacological evaluation.
Gabriela Mazur, Katarzyna Pańczyk-Straszak, Anna Rapacz, Jan Kiszela, Magdalena Smolik, Maria Walczak

Chem Biol Drug Des· February 2023

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KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain.
Anna Waszkielewicz, Henryk Marona, Katarzyna Pańczyk-Straszak, Barbara Filipek, Anna Rapacz, Maria Walczak

Pharmacol Rep· February 2023

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Hybrid molecules combining GABA-A and serotonin 5-HT receptors activity designed to tackle neuroinflammation associated with depression.
Monika Marcinkowska, Barbara Mordyl, Nikola Fajkis-Zajaczkowska, Agata Siwek, Tadeusz Karcz, Maria Walczak

Eur J Med Chem· February 2023

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The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
Magdalena Jastrzębska-Więsek, Magdalena Kotańska, Aleksandra Grzeszczak, Anna Jaromin, Maria Walczak

Int J Mol Sci· September 2022

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Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
Katarzyna Grychowska, Agnieszka Olejarz-Maciej, Klaudia Blicharz, Wojciech Pietruś, Tadeusz Karcz, Maria Walczak

Eur J Med Chem· June 2022

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Comparison of anti-cancer effects of novel protein disulphide isomerase (PDI) inhibitors in breast cancer cells characterized by high and low PDIA17 expression.
Anna Kurpińska, Joanna Suraj-Prażmowska, Marta Stojak, Joanna Jarosz, Łukasz Mateuszuk, Maria Walczak

Cancer Cell Int· June 2022

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Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia.
Agnieszka Zagórska, Adam Bucki, Anna Partyka, Magdalena Jastrzębska-Więsek, Agata Siwek, Maria Walczak

Eur J Med Chem· April 2022

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Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6-Hz corneal stimulation model in mice.
Mirosław Zagaja, Jarosław Bryda, Aleksandra Szewczyk, Joanna Szala-Rycaj, Jarogniew J Łuszczki, Maria Walczak

Fundam Clin Pharmacol· February 2022

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Simultaneous quantification of selected glycosaminoglycans by butanolysis-based derivatization and LC-SRM/MS analysis for assessing glycocalyx disruption in vitro and in vivo.
Karolina Matyjaszczyk-Gwarda, Agnieszka Kij, Mariola Olkowicz, Benedikt Fels, Kristina Kusche-Vihrog, Maria Walczak

Talanta· February 2022

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Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HTR antagonists with β-amyloid anti-aggregation properties.
Tomasz Wichur, Justyna Godyń, Izabella Góral, Gniewomir Latacz, Adam Bucki, Maria Walczak

Eur J Med Chem· December 2021

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A preliminary metabolites identification of a novel compound with β-adrenolytic activity.
Maria Walczak, Joanna Suraj-Prażmowska, Kamil Kuś, Agnieszka Kij, Grażyna Groszek

Pharmacol Rep· October 2021

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Neuropathic pain-alleviating activity of novel 5-HT receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide.
Marcin Drop, Florian Jacquot, Vittorio Canale, Severine Chaumont-Dubel, Maria Walczak

Bioorg Chem· October 2021

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Thrombin Inhibition Prevents Endothelial Dysfunction and Reverses 20-HETE Overproduction without Affecting Blood Pressure in Angiotensin II-Induced Hypertension in Mice.
Agnieszka Kij, Anna Bar, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Maria Walczak

Int J Mol Sci· August 2021

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2-Phenyl-1-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT Receptor Inverse Agonists with Cognition-Enhancing Activity.
Marcin Drop, Vittorio Canale, Séverine Chaumont-Dubel, Rafał Kurczab, Grzegorz Satała, Maria Walczak

ACS Chem Neurosci· April 2021

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