Publications by authors named "Mario Varasi"

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B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements.
Gabriele Varano, Silvia Lonardi, Paola Sindaco, Ilaria Pietrini, Gaia Morello, Mario Varasi

Blood Cancer Discov· July 2025

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The CRL7 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels.
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Mario Varasi

Adv Sci (Weinh)· July 2025

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Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.
Elena Maspero, Anna Cappa, Janine Weber, Paolo Trifirò, Raffaella Amici, Mario Varasi

Commun Chem· May 2025

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A multiparametric screen uncovers FDA-approved small molecules that potentiate the nuclear mechano-dysfunctions in ATR-defective cells.
Maria Rosaria Cera, Giulia Bastianello, Divya Purushothaman, Adrian Andronache, Flora Ascione, Mario Varasi

Sci Rep· December 2024

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Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma.
Silvia Brambillasca, Maria Rosaria Cera, Adrian Andronache, Sumit Kumar Dey, Giovanni Fagá, Mario Varasi

Biomed Pharmacother· August 2024

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A high-throughput screening identifies MCM chromatin loading inhibitors targeting cells with increased replication origins.
Lucia Falbo, Hervé Técher, Vincenzo Sannino, Michela Robusto, Giovanni Fagà, Mario Varasi

iScience· August 2024

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Enrichment of DNA replication intermediates by EdU pull down.
Fabio Pessina, Alessia Romussi, Daniele Piccini, Giulia Mazzucco, Mario Varasi

Methods Cell Biol· February 2024

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Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion.
Rani Pallavi, Elena Gatti, Tiphanie Durfort, Massimo Stendardo, Roberto Ravasio, Mario Varasi

Nat Commun· January 2024

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dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders.
Alejandro López-Tobón, Reinald Shyti, Carlo Emanuele Villa, Cristina Cheroni, Patricio Fuentes-Bravo, Mario Varasi

Sci Adv· December 2023

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Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Elisabetta Di Bello, Veronica Sian, Giulio Bontempi, Clemens Zwergel, Rossella Fioravanti, Mario Varasi

Eur J Med Chem· February 2023

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LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response.
Stefania Faletti, Daniela Osti, Elena Ceccacci, Cristina Richichi, Brunella Costanza, Mario Varasi

Sci Transl Med· December 2021

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Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity.
Clemens Zwergel, Elisabetta Di Bello, Rossella Fioravanti, Mariarosaria Conte, Angela Nebbioso, Mario Varasi

ChemMedChem· March 2021

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High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Francesca Cavallo, Flavia Troglio, Giovanni Fagà, Daniele Fancelli, Reinald Shyti, Mario Varasi

Mol Autism· November 2020

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Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition.
Amal Kamal Abdel-Aziz, Isabella Pallavicini, Elena Ceccacci, Giuseppe Meroni, Mona Kamal Saadeldin, Mario Varasi

Haematologica· August 2020

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Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
Alessia Romussi, Anna Cappa, Paola Vianello, Silvia Brambillasca, Maria Rosaria Cera, Mario Varasi

ACS Med Chem Lett· May 2020

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Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.
Rossella Fioravanti, Annalisa Romanelli, Nicola Mautone, Elisabetta Di Bello, Annarita Rovere, Mario Varasi

ChemMedChem· April 2020

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Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Roberto Ravasio, Elena Ceccacci, Luciano Nicosia, Amir Hosseini, Pier Luigi Rossi, Mario Varasi

Sci Adv· April 2020

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New targets to modulate the DNA damage response.
Ciro Mercurio, Mario Varasi

Future Med Chem· October 2018

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New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
Giuseppe La Regina, Ruoli Bai, Antonio Coluccia, Valentina Naccarato, Valeria Famiglini, Mario Varasi

Eur J Med Chem· May 2018

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PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.
Elisa Ferrari, Christopher Bruhn, Marta Peretti, Corinne Cassani, Walter Vincenzo Carotenuto, Mario Varasi

Mol Cell· July 2017

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Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.
Paolo Trifirò, Anna Cappa, Silvia Brambillasca, Oronza A Botrugno, Maria Rosaria Cera, Mario Varasi

Future Med Chem· July 2017

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3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.
Giuseppe La Regina, Ruoli Bai, Antonio Coluccia, Valeria Famiglini, Sara Passacantilli, Mario Varasi

ACS Med Chem Lett· May 2017

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Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
Luca Sartori, Ciro Mercurio, Federica Amigoni, Anna Cappa, Giovanni Fagá, Mario Varasi

J Med Chem· March 2017

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Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
Paola Vianello, Luca Sartori, Federica Amigoni, Anna Cappa, Giovanni Fagá, Mario Varasi

J Med Chem· March 2017

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Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
Paola Vianello, Oronza A Botrugno, Anna Cappa, Roberto Dal Zuffo, Paola Dessanti, Mario Varasi

J Med Chem· February 2016

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