Publications by authors named "Mark Forman"

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Palatability and Swallowability of Pimavanserin When Mixed with Selected Food Vehicles: An Exploratory Open-Label Crossover Study.
Mark Forman, Alex Kouassi, Teresa Brandt, Lee Barsky, Cynthia Zamora

Geriatrics (Basel)· June 2021

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Safety, Tolerability, and Pharmacokinetics of the β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Verubecestat (MK-8931) in Healthy Elderly Male and Female Subjects.
Mark Forman, John Palcza, Jack Tseng, Julie A Stone, Brittany Walker

Clin Transl Sci· September 2019

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Pharmacokinetics and Pharmacodynamics of the BACE1 Inhibitor Verubecestat (MK-8931) in Healthy Japanese Adults: A Randomized, Placebo-Controlled Study.
K Chris Min, Marissa F Dockendorf, John Palcza, Jack Tseng, Lei Ma, Mark S Forman

Clin Pharmacol Ther· May 2019

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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles.
Talakad G Lohith, Idriss Bennacef, Rik Vandenberghe, Mathieu Vandenbulcke, Cristian A Salinas, Mark Forman

J Nucl Med· January 2019

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Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development.
Gil D Rabinovici, Maria C Carrillo, Mark Forman, Susan DeSanti, David S Miller

Alzheimers Dement (N Y)· January 2017

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Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
Jack D Scott, Sarah W Li, Andrew P J Brunskill, Xia Chen, Kathleen Cox, Mark Forman

J Med Chem· December 2016

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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.
Matthew E Kennedy, Andrew W Stamford, Xia Chen, Kathleen Cox, Jared N Cumming, Mark S Forman

Sci Transl Med· November 2016

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Structures and Rotational Barriers of a Diiodobinorsnoutane: Energetic Preference for Gauche Conformation.
Joseph P Herres, Caitlin A Moran, Mark A Forman, James E Hall, John P McCauley

J Org Chem· August 2016

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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.
Anthony L Gotter, Mark S Forman, Charles M Harrell, Joanne Stevens, Vladimir Svetnik

Sci Rep· June 2016

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An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.
Brendan P Lucey, Celedon Gonzales, Ujjwas Das, Jinhe Li, Eric R Siemers, Mark Forman

Alzheimers Res Ther· May 2016

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Effect of tubing condensate on non-invasive positive pressure ventilators tested under simulated clinical conditions.
Diana Elizabeth Hart, Mark Forman, Andrew G Veale

Sleep Breath· September 2011

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TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
Gillian P Ritson, Sara K Custer, Brian D Freibaum, Jake B Guinto, Dyanna Geffel, Mark S Forman

J Neurosci· June 2010

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VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death.
Michael A Gitcho, Jeffrey Strider, Deborah Carter, Lisa Taylor-Reinwald, Mark S Forman

J Biol Chem· May 2009

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Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Manuela Neumann, Linda K Kwong, Edward B Lee, Elisabeth Kremmer, Andrew Flatley, Mark S Forman

Acta Neuropathol· February 2009

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Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies.
Kunihiro Uryu, Hanae Nakashima-Yasuda, Mark S Forman, Linda K Kwong, Christopher M Clark

J Neuropathol Exp Neurol· June 2008

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Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia.
Virginia E Kimonis, Sarju G Mehta, Erin C Fulchiero, Dana Thomasova, Marzia Pasquali, Mark S Forman

Am J Med Genet A· March 2008

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Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia.
Murray Grossman, David J Libon, Mark S Forman, Lauren Massimo, Elisabeth Wood

Arch Neurol· November 2007

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TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Murray Grossman, Elisabeth M Wood, Peachie Moore, Manuela Neumann, Linda Kwong, Mark S Forman

Arch Neurol· October 2007

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TDP-43: a novel neurodegenerative proteinopathy.
Mark S Forman, John Q Trojanowski, Virginia M-Y Lee

Curr Opin Neurobiol· October 2007

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Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.
Vivianna M Van Deerlin, Elisabeth McCarty Wood, Peachie Moore, Wuxing Yuan, Mark S Forman

Arch Neurol· August 2007

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Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.
Jake B Guinto, Gillian P Ritson, J Paul Taylor, Mark S Forman

Acta Neuropathol· July 2007

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TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
Nigel J Cairns, Manuela Neumann, Eileen H Bigio, Ida E Holm, Dirk Troost, Mark S Forman

Am J Pathol· July 2007

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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Ian R A Mackenzie, Eileen H Bigio, Paul G Ince, Felix Geser, Manuela Neumann, Mark S Forman

Ann Neurol· May 2007

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Generation and reactions of Pentacyclo[4.3.0.0(2,4).0(3,8).0(5,7)]non-4-ene.
Mark A Forman, Caitlin Moran, Joseph P Herres, Jason Stairs, Emily Chopko

J Org Chem· April 2007

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TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Manuela Neumann, Ian R Mackenzie, Nigel J Cairns, Philip J Boyer, William R Markesbery, Mark S Forman

J Neuropathol Exp Neurol· February 2007

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