Publications by authors named "Mark Witmer"

Claim this Profile
D
Design, Synthesis, and T Cell Checkpoint Combination Potential Of First-In-Class DGKα/ζ Inhibitor BMS-986408.
Denise C Grünenfelder, Upender Velaparthi, Jayakumar S Warrier, Louis Chupak, Chetan Padmakar Darne, Mark Witmer

J Med Chem· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).
Jennifer X Qiao, Mark R Witmer, Ving Lee, Tammy C Wang, Patrick C Reid

Bioorg Med Chem Lett· January 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
Kap-Sun Yeung, Brett R Beno, Kathy Mosure, Juliang Zhu, Katherine A Grant-Young, Mark Witmer

ACS Med Chem Lett· December 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An improved protocol for amino acid type-selective isotope labeling in insect cells.
Yaqun Zhang, Hui Wei, Dianlin Xie, Deepa Calambur, Andrew Douglas, Mark R Witmer

J Biomol NMR· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Kap-Sun Yeung, Brett R Beno, Kyle Parcella, John A Bender, Katherine A Grant-Young, Mark Witmer

J Med Chem· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders.
Hao Lu, Lisa Kopcho, Kaushik Ghosh, Mark Witmer, Michael Parker

Anal Biochem· May 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Biotechnology Based Process for Production of a Disulfide-Bridged Peptide.
Animesh Goswami, Steven L Goldberg, Ronald L Hanson, Robert M Johnston, Olav K Lyngberg, Mark Witmer

Bioconjug Chem· May 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
John S Tokarski, Adriana Zupa-Fernandez, Jeffrey A Tredup, Kristen Pike, ChiehYing Chang, Mark R Witmer

J Biol Chem· April 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
High-throughput high-content imaging assays for identification and characterization of selective AXL pathway inhibitors.
Huaping Tang, Jing Yang, Ding Ren Shen, Deepa Calambur, Mark Witmer

Assay Drug Dev Technol· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering.
Tracy Mitchell, Ginger Chao, Doree Sitkoff, Fred Lo, Hossain Monshizadegan, Mark Witmer

J Pharmacol Exp Ther· August 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
Robert G Gentles, Min Ding, John A Bender, Carl P Bergstrom, Katharine Grant-Young, Mark R Witmer

J Med Chem· March 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Stephen T Wrobleski, Shuqun Lin, T G Murali Dhar, Alaric J Dyckman, Tianle Li, Mark R Witmer

Bioorg Med Chem Lett· July 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Xiaofan Zheng, Thomas W Hudyma, Scott W Martin, Carl Bergstrom, Min Ding, Mark R Witmer

Bioorg Med Chem Lett· May 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Robert G Gentles, Steven Sheriff, Brett R Beno, Changhong Wan, Kevin Kish, Mark R Witmer

Bioorg Med Chem Lett· April 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.
Steve Poirier, Gaetan Mayer, Viviane Poupon, Peter S McPherson, Roxane Desjardins, Mark Witmer

J Biol Chem· October 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A global benchmark study using affinity-based biosensors.
Rebecca L Rich, Giuseppe A Papalia, Peter J Flynn, Jamie Furneisen, John Quinn, Mark Witmer

Anal Biochem· March 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.
Gregory A Locke, Dong Cheng, Mark R Witmer, James K Tamura, Tasir Haque

Arch Biochem Biophys· July 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Scott H Watterson, Ping Chen, Yufen Zhao, Henry H Gu, T G Murali Dhar, Mark Witmer

J Med Chem· July 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme.
Michael G Kornacker, Zhihong Lai, Mark Witmer, Jianghong Ma, Joseph Hendrick

Biochemistry· August 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.
Theodore E Carver, Brian Bordeau, Maxwell D Cummings, Eugene C Petrella, Michael J Pucci, Mark R Witmer

J Biol Chem· March 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.
Ping Chen, Arthur M Doweyko, Derek Norris, Henry H Gu, Steven H Spergel, Mark R Witmer

J Med Chem· August 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.
Larisa Toulokhonova, William J Metzler, Mark R Witmer, Robert A Copeland, Jovita Marcinkeviciene

J Biol Chem· February 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Scott H Watterson, Marianne Carlsen, T G Murali Dhar, Zhongqi Shen, William J Pitts, Mark Witmer

Bioorg Med Chem Lett· February 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.
Lisa M Kopcho, Jianhong Ma, Jovita Marcinkeviciene, Zhihong Lai, Mark R Witmer

Arch Biochem Biophys· February 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
T G Murali Dhar, Zhongqi Shen, Junqing Guo, Chunjian Liu, Scott H Watterson, Mark R Witmer

J Med Chem· May 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis