Publications by authors named "Markus Christmann"

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Senotherapeutics in Malignant Brain Cancer Therapy.
Bernd Kaina, Markus Christmann

Curr Oncol Rep· December 2025

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The deacetylases HDAC1/HDAC2 control JAK2-STAT signaling through the ubiquitin ligase SIAH2.
Al-Hassan M Mustafa, Giuseppe Petrosino, Marten A Fischer, Tina M Schnöder, Désirée Gül, Markus Christmann

Signal Transduct Target Ther· August 2025

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IDH1 Mutation Impacts DNA Repair Through ALKBH2 Rendering Glioblastoma Cells Sensitive to Artesunate.
Olivier Switzeny, Stefan Pusch, Markus Christmann, Bernd Kaina

Biomedicines· June 2025

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Therapy-induced senescence of glioblastoma cells is determined by the p21-CDK1/2 axis and does not require activation of DREAM.
Christian Schwarzenbach, Justus Rinke, Juliana B Vilar, Jason Sallbach, Larissa Tatsch, Markus Christmann

Cell Death Dis· May 2025

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The cell cycle inhibitor p21 is essential for irinotecan-induced senescence and plays a decisive role in re-sensitization of temozolomide-resistant glioblastoma cells to irinotecan.
Jason Sallbach, Melanie Woods, Birgit Rasenberger, Markus Christmann, Maja T Tomicic

Biomed Pharmacother· December 2024

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The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence.
Ariane Schmidt, Sebastian Allmann, Christian Schwarzenbach, Petra Snyder, Jia-Xuan Chen, Markus Christmann

Nucleic Acids Res· July 2024

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Genotoxic and Cytotoxic Activity of Fisetin on Glioblastoma Cells.
Lea Beltzig, Markus Christmann, Minodora Dobreanu, Bernd Kaina

Anticancer Res· March 2024

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DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways.
Jörg Fahrer, Markus Christmann

Int J Mol Sci· February 2023

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Expression of DNA repair genes and its relevance for DNA repair in peripheral immune cells of patients with posttraumatic stress disorder.
Alexander Behnke, Matthias Mack, Judy Fieres, Markus Christmann, Alexander Bürkle

Sci Rep· November 2022

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p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol.
Max J Carlsson, Anastasia S Vollmer, Philipp Demuth, Daniel Heylmann, Diana Reich, Markus Christmann

Cell Death Dis· November 2022

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Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics.
Lea Beltzig, Markus Christmann, Bernd Kaina

Cells· August 2022

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Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?
Juliana B Vilar, Markus Christmann, Maja T Tomicic

Cancers (Basel)· May 2022

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Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells.
Lea Beltzig, Christian Schwarzenbach, Petra Leukel, Katrin B M Frauenknecht, Clemens Sommer, Markus Christmann

Cancers (Basel)· April 2022

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Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells.
Mandy Beyer, Sven J Henninger, Patricia S Haehnel, Al-Hassan M Mustafa, Ece Gurdal, Markus Christmann

Cell Chem Biol· March 2022

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The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner.
Carina Arnold, Philipp Demuth, Nina Seiwert, Simon Wittmann, Kerstin Boengler, Markus Christmann

Mol Cancer Ther· January 2022

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Repair of O6-carboxymethylguanine adducts by O6-methylguanine-DNA methyltransferase in human colon epithelial cells.
Tina Kostka, Michael T Empl, Nina Seiwert, Susanne M Geisen, Pascal Hoffmann, Markus Christmann

Carcinogenesis· August 2021

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Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination.
Thomas R Reich, Christian Schwarzenbach, Juliana Brandstetter Vilar, Sven Unger, Fabian Mühlhäusler, Markus Christmann

Cell Mol Life Sci· July 2021

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Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment.
Christian Schwarzenbach, Larissa Tatsch, Juliana Brandstetter Vilar, Birgit Rasenberger, Lea Beltzig, Markus Christmann

Cancers (Basel)· July 2021

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Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-type and Mutant Colorectal Cancer.
Apisada Jiso, Philipp Demuth, Madeleine Bachowsky, Manuel Haas, Nina Seiwert, Markus Christmann

Cancers (Basel)· June 2021

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Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14-Mediated Sustained p53 Activation.
Maja T Tomicic, Franziska Krämer, Alexandra Nguyen, Christian Schwarzenbach, Markus Christmann

Cancers (Basel)· April 2021

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Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence.
Sebastian Allmann, Laura Mayer, Jessika Olma, Bernd Kaina, Thomas G Hofmann, Markus Christmann

Nucleic Acids Res· December 2020

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Epigenetic regulation of DNA repair genes and implications for tumor therapy.
Markus Christmann, Bernd Kaina

Mutat Res Rev Mutat Res· March 2020

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Corrigendum to "DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas" [DNA Repair 78 (2019) 128-141].
Bernd Kaina, Markus Christmann

DNA Repair (Amst)· August 2019

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Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6.
Maja T Tomicic, Christian Steigerwald, Birgit Rasenberger, Anamaria Brozovic, Markus Christmann

Arch Toxicol· August 2019

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Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation.
Carina Neitzel, Nina Seiwert, Anja Göder, Erika Diehl, Carina Weber, Markus Christmann

Cells· July 2019

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