Publications by authors named "Matthew James Bottomley"

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Structures of the Varicella Zoster Virus Glycoprotein E and Epitope Mapping of Vaccine-Elicited Antibodies.
Wayne D Harshbarger, Genevieve Holzapfel, Nishat Seraj, Sai Tian, Chelsy Chesterman, Matthew James Bottomley

Vaccines (Basel)· September 2024

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Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.
James A Williams, Marco Biancucci, Laura Lessen, Sai Tian, Ankita Balsaraf, Matthew James Bottomley

Sci Adv· June 2023

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Effective Multivalent Oriented Presentation of Meningococcal NadA Antigen Trimers by Self-Assembling Ferritin Nanoparticles.
Daniele Veggi, Lucia Dello Iacono, Enrico Malito, Giulietta Maruggi, Fabiola Giusti, Matthew James Bottomley

Int J Mol Sci· March 2023

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Self-assembling protein nanoparticles and virus like particles correctly display β-barrel from meningococcal factor H-binding protein through genetic fusion.
Luigia Cappelli, Paolo Cinelli, Fabiola Giusti, Ilaria Ferlenghi, Sabrina Utrio-Lanfaloni, Matthew James Bottomley

PLoS One· September 2022

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Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients.
Matthew Oliver Brook, Joanna Hester, William Petchey, Ines Rombach, Susan Dutton, Matthew James Bottomley

BMJ Open· April 2022

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Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Wayne Harshbarger, Priyanka D Abeyrathne, Sai Tian, Ying Huang, Sumana Chandramouli, Matthew James Bottomley

MAbs· January 2022

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Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F.
Wayne Harshbarger, Sai Tian, Newton Wahome, Ankita Balsaraf, Deep Bhattacharya, Matthew James Bottomley

PLoS Pathog· November 2020

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Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA.
Martina Maritan, Roberta Cozzi, Paola Lo Surdo, Daniele Veggi, Matthew James Bottomley

Acta Crystallogr F Struct Biol Commun· June 2017

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Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens.
Lassi Liljeroos, Enrico Malito, Ilaria Ferlenghi, Matthew James Bottomley

J Immunol Res· August 2016

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Crystal structure of FhuD at 1.6 Å resolution: a ferrichrome-binding protein from the animal and human pathogen Staphylococcus pseudintermedius.
Francesca Abate, Roberta Cozzi, Martina Maritan, Paola Lo Surdo, Domenico Maione, Matthew James Bottomley

Acta Crystallogr F Struct Biol Commun· March 2016

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Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein.
Danilo Donnarumma, Giacomo Golfieri, Sébastien Brier, Marta Castagnini, Daniele Veggi, Matthew James Bottomley

FASEB J· June 2015

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Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.
Enrico Malito, Marco Biancucci, Agnese Faleri, Ilaria Ferlenghi, Maria Scarselli, Matthew James Bottomley

Proc Natl Acad Sci U S A· December 2014

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Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SpyCEP, a candidate antigen for a vaccine against Streptococcus pyogenes.
Francesca Abate, Enrico Malito, Fabiana Falugi, Immaculada Margarit Y Ros, Matthew James Bottomley

Acta Crystallogr Sect F Struct Biol Cryst Commun· October 2013

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Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.
Enrico Malito, Badry Bursulaya, Connie Chen, Paola Lo Surdo, Monica Picchianti, Matthew James Bottomley

Proc Natl Acad Sci U S A· April 2012

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Rational design of a meningococcal antigen inducing broad protective immunity.
Maria Scarselli, Beatrice Aricò, Brunella Brunelli, Silvana Savino, Federica Di Marcello, Matthew James Bottomley

Sci Transl Med· July 2011

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Structural characterization of the Hepatitis C Virus NS3 protease from genotype 3a: the basis of the genotype 1b vs. 3a inhibitor potency shift.
Mariana Gallo, Matthew James Bottomley, Matteo Pennestri, Tommaso Eliseo, Maurizio Paci

Virology· September 2010

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Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor.
Mariana Gallo, Matteo Pennestri, Matthew James Bottomley, Gaetano Barbato, Tommaso Eliseo

J Mol Biol· January 2009

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DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity.
Ingrid Liiv, Ana Rebane, Tõnis Org, Mario Saare, Julia Maslovskaja, Matthew James Bottomley

Biochim Biophys Acta· January 2008

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(1)H, (13)C and (15)N backbone assignments for the ligand binding domain of the Pseudomonas aeruginosa virulence regulator LasR.
Matthew James Bottomley, Ester Muraglia, Renzo Bazzo

Biomol NMR Assign· December 2007

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NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease.
Matthew James Bottomley, Gunter Stier, Danilo Pennacchini, Gaelle Legube, Bernd Simon

J Biol Chem· March 2005

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