Publications by authors named "Matthew W D Perry"

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How to Design an Inhaled Drug: CHF-6523.
Matthew W D Perry

J Med Chem· February 2025

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Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction".
Jakob S Pallesen, Claire C Munier, Francesco Bosica, Sebastian A Andrei, Karl Edman, Matthew W D Perry

J Med Chem· February 2023

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Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
Jakob S Pallesen, Claire C Munier, Francesco Bosica, Sebastian A Andrei, Karl Edman, Matthew W D Perry

J Med Chem· December 2022

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Surprising lipophilicity observations identify unexpected conformational effects.
Matthew W D Perry, Ulf Börjesson, Antonios Nikitidis, Christian Tyrchan

Bioorg Med Chem Lett· August 2022

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PI3K inhibitors are finally coming of age.
Bart Vanhaesebroeck, Matthew W D Perry, Jennifer R Brown, Fabrice André, Klaus Okkenhaug

Nat Rev Drug Discov· October 2021

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Author Correction: PI3K inhibitors are finally coming of age.
Bart Vanhaesebroeck, Matthew W D Perry, Jennifer R Brown, Fabrice André, Klaus Okkenhaug

Nat Rev Drug Discov· October 2021

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Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
Claire C Munier, Leonardo De Maria, Karl Edman, Anders Gunnarsson, Marianna Longo, Matthew W D Perry

J Biol Chem· August 2021

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Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.
Matthew W D Perry, Karin Björhall, Peter Bold, Mikael Brűlls, Ulf Börjesson

J Med Chem· June 2021

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14-3-3 modulation of the inflammatory response.
Claire C Munier, Christian Ottmann, Matthew W D Perry

Pharmacol Res· January 2021

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Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction.
Leire Iralde-Lorente, Giusy Tassone, Letizia Clementi, Lorenzo Franci, Claire C Munier, Matthew W D Perry

ACS Chem Biol· April 2020

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Design, Synthesis, and Biological Evaluation of MEK PROTACs.
Stefan Vollmer, Danen Cunoosamy, Huafei Lv, Huanxi Feng, Xia Li, Matthew W D Perry

J Med Chem· January 2020

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Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.
Matthew W D Perry, Raolat Abdulai, Mickael Mogemark, Jens Petersen, Matthew J Thomas

J Med Chem· May 2019

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A class of highly selective inhibitors bind to an active state of PI3Kγ.
Gangadhara Gangadhara, Göran Dahl, Thomas Bohnacker, Rebecca Rae, Jenny Gunnarsson, Matthew W D Perry

Nat Chem Biol· April 2019

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors.
Nils Pemberton, Mickael Mogemark, Susanne Arlbrandt, Peter Bold, Rhona J Cox, Matthew W D Perry

J Med Chem· June 2018

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Stabilization of protein-protein interactions in drug discovery.
Sebastian A Andrei, Eline Sijbesma, Michael Hann, Jeremy Davis, Gavin O'Mahony, Matthew W D Perry

Expert Opin Drug Discov· September 2017

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Erratum: Structural and conformational determinants of macrocycle cell permeability.
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Matthew W D Perry

Nat Chem Biol· July 2017

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Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration.
Matthew W D Perry, Karin Björhall, Britta Bonn, Johan Carlsson, Yunhua Chen

J Med Chem· June 2017

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Structural and conformational determinants of macrocycle cell permeability.
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Matthew W D Perry

Nat Chem Biol· December 2016

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Designing novel building blocks is an overlooked strategy to improve compound quality.
Frederick W Goldberg, Jason G Kettle, Thierry Kogej, Matthew W D Perry, Nick P Tomkinson

Drug Discov Today· January 2015

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Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.
Björn Over, Patrick McCarren, Per Artursson, Michael Foley, Fabrizio Giordanetto, Matthew W D Perry

J Med Chem· March 2014

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Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.
Ash Bahl, Patrick Barton, Keith Bowers, Moya V Caffrey, Rebecca Denton, Matthew W D Perry

Bioorg Med Chem Lett· November 2012

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The discovery of CCR3/H1 dual antagonists with reduced hERG risk.
Ash Bahl, Patrick Barton, Keith Bowers, Steven Brough, Richard Evans, Matthew W D Perry

Bioorg Med Chem Lett· November 2012

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Spiro-fused pyrrolidine, piperidine, and oxindole scaffolds from lactams.
Christoph Hirschhäuser, Jeremy S Parker, Matthew W D Perry, Mairi F Haddow, Timothy Gallagher

Org Lett· September 2012

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A practical method for targeted library design balancing lead-like properties with diversity.
Michael J Stocks, Gareth R H Wilden, Garry Pairaudeau, Matthew W D Perry, John Steele

ChemMedChem· May 2009

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Monocarboxylate transporter MCT1 is a target for immunosuppression.
Clare M Murray, Raymond Hutchinson, John R Bantick, Graham P Belfield, Amanda D Benjamin, Matthew W D Perry

Nat Chem Biol· December 2005

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