Publications by authors named "Nils Pemberton"

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The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity.
Linda Öster, Marie Castaldo, Emma de Vries, Fredrik Edfeldt, Nils Pemberton

J Biol Chem· May 2024

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Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR.
Nils Pemberton, Nina Compagne, Argyrides Argyrou, Emma Evertsson, Anders Gunnarsson

ACS Med Chem Lett· May 2024

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Exploring the Dispersion and Electrostatic Components in Arene-Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands.
Måns Andreasson, Maxime Donzel, Alva Abrahamsson, Andreas Berner, Mara Doimo, Nils Pemberton

J Med Chem· February 2024

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Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Lena Ripa, Jenny Sandmark, Glyn Hughes, Igor Shamovsky, Anders Gunnarsson, Nils Pemberton

J Med Chem· October 2023

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Using Macrocyclic G-Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G-Quadruplex DNA.
Måns Andréasson, Naresh Bhuma, Nils Pemberton, Erik Chorell

Chemistry· November 2022

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Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.
Matthew W D Perry, Karin Björhall, Peter Bold, Mikael Brűlls, Ulf Börjesson, Nils Pemberton

J Med Chem· June 2021

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A class of highly selective inhibitors bind to an active state of PI3Kγ.
Gangadhara Gangadhara, Göran Dahl, Thomas Bohnacker, Rebecca Rae, Jenny Gunnarsson, Nils Pemberton

Nat Chem Biol· April 2019

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Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors.
Nils Pemberton, Mickael Mogemark, Susanne Arlbrandt, Peter Bold, Rhona J Cox

J Med Chem· June 2018

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Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration.
Matthew W D Perry, Karin Björhall, Britta Bonn, Johan Carlsson, Yunhua Chen, Nils Pemberton

J Med Chem· June 2017

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Chroman-4-one and chromone based somatostatin β-turn mimetics.
Maria Fridén-Saxin, Tina Seifert, Marcus Malo, Krystle da Silva Andersson, Nils Pemberton

Eur J Med Chem· May 2016

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Synthesis and functionalization of cyclic sulfonimidamides: a novel chiral heterocyclic carboxylic Acid bioisostere.
Nils Pemberton, Henrik Graden, Emma Evertsson, Emma Bratt, Matti Lepistö

ACS Med Chem Lett· July 2012

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KHMDS enhanced SmI(2)-mediated reformatsky type alpha-cyanation.
Tobias Ankner, Maria Fridén-Saxin, Nils Pemberton, Tina Seifert, Morten Grøtli

Org Lett· May 2010

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Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.
Maria Fridén-Saxin, Nils Pemberton, Krystle da Silva Andersson, Christine Dyrager, Annika Friberg

J Org Chem· April 2009

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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
Jerome S Pinkner, Han Remaut, Floris Buelens, Eric Miller, Veronica Aberg, Nils Pemberton

Proc Natl Acad Sci U S A· November 2006

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Synthesis of multi ring-fused 2-pyridones via an acyl-ketene imine cyclocondensation.
Nils Pemberton, Lotta Jakobsson, Fredrik Almqvist

Org Lett· March 2006

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NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.
Mattias Hedenström, Hans Emtenäs, Nils Pemberton, Veronica Aberg, Scott J Hultgren

Org Biomol Chem· December 2005

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Cycloaddition of delta2-thiazolines and acyl ketenes under acidic conditions results in bicyclic 1,3-oxazinones and not 6-acylpenams as earlier reported.
Nils Pemberton, Hans Emtenäs, Dan Boström, Peter J Domaille, William A Greenberg

Org Lett· March 2005

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Microwave-assisted synthesis of highly substituted aminomethylated 2-pyridones.
Nils Pemberton, Veronica Aberg, Hanna Almstedt, Andreas Westermark, Fredrik Almqvist

J Org Chem· November 2004

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