Publications by authors named "Matthias Engel"

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Targeting Neutrophil-Mediated Inflammation: Identification of Pyrazolidinone Carboxamide Derivatives as Potent Selective Inhibitors of Formyl Peptide Receptor 1 (FPR1)-Activated Neutrophils.
Mohammad Abdel-Halim, Reem A Wagdy, Mohamed Salah, Yi-Hsuan Wang, Tzu-Peng Cheng, Matthias Engel

ACS Pharmacol Transl Sci· June 2025

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Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription.
Sara Sigler, Mohammad Abdel-Halim, Reem K Fathalla, Luciana Madeira Da Silva, Adam B Keeton, Matthias Engel

Anticancer Agents Med Chem· April 2025

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From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds.
Parthiena M Keddis, Tuong-Khanh My Tu, Hugo Scherer, Andreas M Kany, Donia E Hafez, Matthias Engel

Eur J Med Chem· April 2025

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Discovery of a novel, selective CK2 inhibitor class with an unusual basic scaffold.
Hend Khalifa, Ahmed K ElHady, Ting Liu, Walid A M Elgaher, Odile Filhol-Cochet, Matthias Engel

Eur J Med Chem· January 2025

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Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways.
Mohammad Abdel-Halim, Dalia S El-Gamil, Mennatallah A Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Matthias Engel

J Enzyme Inhib Med Chem· December 2024

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Design, synthesis, and structure-activity relationship studies of 6-benzo[]indeno[1,2-]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors.
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Matthias Engel

RSC Med Chem· October 2024

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Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds.
Lissy Z F Gross, Angelika F Winkel, Facundo Galceran, Jörg O Schulze, Wolfgang Fröhner, Matthias Engel

J Biol Chem· August 2024

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Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity.
Yara A Abd El-Rahman, Po-Jen Chen, Ahmed K ElHady, Shun-Hua Chen, Hsin-Chieh Lin, Matthias Engel

Future Med Chem· July 2024

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N-Benzoylated 5-(4-pyridinyl)indazole-based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents.
Habiba G Aboelfotouh, Mennatallah Abdallah, Hend Khalifa, Youssef Aboushady, Ashraf H Abadi, Matthias Engel

Arch Pharm (Weinheim)· June 2024

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-Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents.
Noha Mostafa, Po-Jen Chen, Sarah S Darwish, Yu-Chieh Su, Ming-Hua Shiao, Matthias Engel

Cancers (Basel)· May 2024

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Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents.
Hend Khalifa, Sari Rasheed, Jörg Haupenthal, Jennifer Herrmann, Yasmine M Mandour, Matthias Engel

Arch Pharm (Weinheim)· April 2024

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Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors.
Mona M Shawky, Mennatallah Abdallah, Hend Khalifa, Youssef Aboushady, Ashraf H Abadi, Matthias Engel

Bioorg Chem· April 2024

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Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity.
Omar M Al-Saad, Moustafa Gabr, Sarah S Darwish, Mariagrazia Rullo, Leonardo Pisani, Matthias Engel

Eur J Med Chem· April 2024

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Discovery of 1,2-diaryl-3-oxopyrazolidin-4-carboxamides as a new class of MurA enzyme inhibitors and characterization of their antibacterial activity.
Reem A Wagdy, Nader S Abutaleb, Reem K Fathalla, Yehia Elgammal, Stefanie Weck, Matthias Engel

Eur J Med Chem· December 2023

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Targeting the binding pocket of the fluorophore 8-anilinonaphthalene-1-sulfonic acid in the bacterial enzyme MurA.
Reem K Fathalla, Matthias Engel, Christian Ducho

Arch Pharm (Weinheim)· September 2023

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An overview of cdc2-like kinase 1 (Clk1) inhibitors and their therapeutic indications.
Ahmed K ElHady, Dalia S El-Gamil, Ashraf H Abadi, Mohammad Abdel-Halim, Matthias Engel

Med Res Rev· March 2023

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Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity.
Dalia S El-Gamil, Ahmed K ElHady, Po-Jen Chen, Tsong-Long Hwang, Ashraf H Abadi, Matthias Engel

Eur J Med Chem· February 2023

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Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.
Reem K Fathalla, Wolfgang Fröhner, Chantal D Bader, Patrick D Fischer, Charlotte Dahlem, Matthias Engel

J Med Chem· November 2022

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From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors.
Reem A Wagdy, Po-Jen Chen, Mostafa M Hamed, Sarah S Darwish, Shun-Hua Chen, Matthias Engel

Bioorg Chem· October 2022

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Nanoparticle Fraught Liposomes: A Platform for Increased Antibiotic Selectivity in Multidrug Resistant Bacteria.
Suzan Fangary, Mohammad Abdel-Halim, Reem K Fathalla, Raghda Hassan, Noha Farag, Matthias Engel

Mol Pharm· September 2022

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Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker.
Dalia S El-Gamil, Ahmed K ElHady, Po-Jen Chen, Tsong-Long Hwang, Ashraf H Abadi, Matthias Engel

Eur J Med Chem· August 2022

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Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors.
Sarah S Darwish, Po-Jen Chen, Mostafa M Hamed, Reem A Wagdy, Shun-Hua Chen, Matthias Engel

Pharmaceuticals (Basel)· June 2022

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Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part.
Sarah H Megahed, Sari Rasheed, Jennifer Herrmann, Ebaa M El-Hossary, Yahia I El-Shabrawy, Matthias Engel

Bioorg Med Chem Lett· March 2022

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Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.
Yasmeen T AlNajjar, Moustafa Gabr, Ahmed K ElHady, Mohamed Salah, Gerrit Wilms, Matthias Engel

Eur J Med Chem· January 2022

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Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases.
Youssef Aboushady, Moustafa Gabr, Ahmed K ElHady, Mohamed Salah, Ashraf H Abadi, Matthias Engel

ACS Chem Neurosci· November 2021

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